Skip to Main Content

Author Details

Li-Huei Tsai
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
1991
288
113
PMIDPaper TitleJournal TitlePublished Year
37645757Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model.bioRxiv2024
36593328Insights into Alzheimer's disease from single-cell genomic approaches.Nat Neurosci2023
37642942A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.J Exp Med2023
37043533A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.Proc Natl Acad Sci U S A2023
37075128Lateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease.Sci Transl Med2023
37273653Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function.Front Aging Neurosci2023
37264161Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease.Nat Neurosci2023
37095396Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.Nat Neurosci2023
36683855Cell type-specific histone acetylation profiling of Alzheimer's disease subjects and integration with genetics.Front Mol Neurosci2023
34750588Dissecting the complexities of Alzheimer disease with in vitro models of the human brain.Nat Rev Neurol2022
35499251Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease.EMBO Rep2022
35714196BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1.Sci Adv2022
36456178Correction: Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease.Life Sci Alliance2022
36454969Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies.PLoS One2022
36180790A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes.Nat Neurosci2022
36070677Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration.Cell Metab2022
35904330Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome.Elife2022
36206766Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks.Mol Cell2022
36038771Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy.Nat Biomed Eng2022
36170369Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.Sci Adv2022
36327895Microglia states and nomenclature: A field at its crossroads.Neuron2022
36167428Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease.Life Sci Alliance2022
35987206Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration.Neuron2022
36385529APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.Nature2022
35158371Single-cell dissection of the human brain vasculature.Nature2022
34995493Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors.Cell Stem Cell2022
35263084Histone Deacetylases 1 and 2 in Memory Function.ACS Chem Neurosci2022
34818608Harnessing cerebral organoids for Alzheimer's disease research.Curr Opin Neurobiol2022
34081919Neuronal enhancers get a break.Neuron2021
33792567ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.J Clin Invest2021
33526585Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function.Genes Dev2021
33658354<i>APOE4</i> disrupts intracellular lipid homeostasis in human iPSC-derived glia.Sci Transl Med2021
35036927Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models.Nat Aging2021
34433823Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds.Sci Data2021
34731014MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration.Sci Transl Med2021
34814918Three decades of Cdk5.J Biomed Sci2021
34450034APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation.Stem Cell Reports2021
34156133Induction of specific brain oscillations may restore neural circuits and be used for the treatment of Alzheimer's disease.J Intern Med2021
34197463Profiling DNA break sites and transcriptional changes in response to contextual fear learning.PLoS One2021
34111830Three-dimensional chromatin organization in brain function and dysfunction.Curr Opin Neurobiol2021
31391546Modeling Alzheimer's disease with iPSC-derived brain cells.Mol Psychiatry2020
31836315Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities.Trends Neurosci2020
33253521Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.ACS Chem Neurosci2020
33289969Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.Mol Syst Biol2020
33020654Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble.Nat Neurosci2020
32668255Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.Cell Rep2020
32328622Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration.Cereb Cortex2020
32514169Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.Nat Med2020
30696811S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.Transl Psychiatry2019
31209304Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease.Nature2019
  • 1 - 50 of 288

Recommended Authors

Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
Career Start Year 2011
Number of shared co-authors 7
Daehoon Lee
Case Western Reserve University
Career Start Year 2010
Number of shared co-authors 1
Vicente Herranz-P??rez
Cavanilles Institute, University of Valencia
Career Start Year 2006
Number of shared co-authors 1
Yaqiao Li
Harvard Medical School
Career Start Year 2005
Number of shared co-authors 5
Merina Varghese
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Career Start Year 2005
Number of shared co-authors 5
Priscilla D Negraes
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Career Start Year 2004
Number of shared co-authors 0
Gaia Novarino
Institute of Science and Technology Austria (ISTA)
Career Start Year 2004
Number of shared co-authors 1
Ghazaleh Sadri-Vakili
Sean M. Healey & AMG Center for ALS at Mass General
Career Start Year 2003
Number of shared co-authors 2
Zhexing Wen
Emory University School of Medicine
Career Start Year 2003
Number of shared co-authors 3
Yungui Zhou
Gladstone Institutes
Career Start Year 2001
Number of shared co-authors 6
Byoung-Il Bae
University of Connecticut School of Medicine
Career Start Year 2000
Number of shared co-authors 5
Sang-Won Min
Gladstone Institutes
Career Start Year 2000
Number of shared co-authors 7
Alysson R Muotri
Department of Pediatrics/Rady Children's Hospital, University of California San Diego
Career Start Year 1999
Number of shared co-authors 3
Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Career Start Year 1999
Number of shared co-authors 17
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Career Start Year 1999
Number of shared co-authors 10
Jan Mulder
Karolinska Institute
Career Start Year 1999
Number of shared co-authors 0
Matthew J Huentelman
The Translational Genomics Research Institute (TGen)
Career Start Year 1998
Number of shared co-authors 19
Christopher Dirk Keene
University of Washington
Career Start Year 1998
Number of shared co-authors 22
Sudeshna Das
Massachusetts General Hospital
Career Start Year 1996
Number of shared co-authors 9
Suman Jayadev
University of Washington
Career Start Year 1995
Number of shared co-authors 11
Hyemyung Seo
Center for Bionano Intelligence Education and Research, Hanyang University
Career Start Year 1995
Number of shared co-authors 2
Soren Impey
Cranfield University
Career Start Year 1994
Number of shared co-authors 1
Claudia Crosio
University of Sassari
Career Start Year 1994
Number of shared co-authors 3
Pamela J McMillan
University of Washington
Career Start Year 1993
Number of shared co-authors 0
Daniel H Geschwind
University of California los angeles
Career Start Year 1989
Number of shared co-authors 43
Gwenn A Garden
University of Washington School of Medicine
Career Start Year 1988
Number of shared co-authors 10
Dragan Maric
National Institute of Neurological Disorders and Stroke
Career Start Year 1986
Number of shared co-authors 0
Raymond S Turner
Georgetown University
Career Start Year 1981
Number of shared co-authors 4
Nathaniel Heintz
Howard Hughes Medical Institute, The Rockefeller University
Career Start Year 1980
Number of shared co-authors 2
William C Mobley
University of California San Diego
Career Start Year 1973
Number of shared co-authors 4

Collaborators

Manolis Kellis
Massachusetts Institute of Technology
Co-authored papers 16
Stephen J Haggarty
Co-authored papers 14
David A Bennett
Rush University Medical Center
Co-authored papers 12
Ping-Chieh Pao
Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 10
Edward S Boyden
McGovern Institute for Brain Research
Co-authored papers 8
Andreas R Pfenning
Co-authored papers 6
Wen-Ning Zhao
Co-authored papers 5
Philip L De Jager
Columbia University Medical Center
Co-authored papers 5
Emery N Brown
Massachusetts Institute of Technology
Co-authored papers 4
Sandrine Humbert
Grenoble Institut Neurosciences, INSERM, Universite Grenoble Alpes
Co-authored papers 4
Joseph G Gleeson
University of California
Co-authored papers 3
Jacob D Jaffe
Co-authored papers 3
Eric J Huang
University of California san francisco
Co-authored papers 3
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 3
Malvina Papanastasiou
Co-authored papers 3
Jessica A Cardin
Kavli Institute for Neuroscience, Yale University School of Medicine
Co-authored papers 3
Matthew Meyerson
Broad Institute
Co-authored papers 3
Michael C Oldham
University of California san francisco
Co-authored papers 2
En Li
Co-authored papers 2
Sara Mostafavi
University of British Columbia and BC Children's Hospital
Co-authored papers 2
Anshul Kundaje
Stanford University.
Co-authored papers 2
Christian Haass
German Center for Neurodegenerative Diseases (DZNE) Munich
Co-authored papers 2
Paul L Greer
Co-authored papers 2
Christopher A Walsh
Broad Institute of MIT and Harvard
Co-authored papers 2
Desiree Davison
Co-authored papers 2
Roy H Perlis
Center for Quantitative Health, Massachusetts General Hospital
Co-authored papers 2
Anthony J Filiano
Co-authored papers 2
Hans-Ulrich Klein
Columbia University Irving Medical Center
Co-authored papers 2
Kwanghun Chung
Massachusetts Institute of Technology
Co-authored papers 2
James Mullahoo
Co-authored papers 2
Release 1.2