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Author Details

Charles A Whittaker
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
1993
76
37
PMIDPaper TitleJournal TitlePublished Year
36711745Molecular Logic of Synaptic Diversity Between <i>Drosophila</i> Tonic and Phasic Motoneurons.bioRxiv2023
37611584Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons.Neuron2023
37089874Functional Annotation Routines Used by ABRF Bioinformatics Core Facilities - Observations, Comparisons, and Considerations.J Biomol Tech2023
37123399The environmental stress response regulates ribosome content in cell cycle-arrested <i>S. cerevisiae</i>.Front Cell Dev Biol2023
37413990Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity.Cell2023
37132544BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.Pigment Cell Melanoma Res2023
37098922Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases.Cancer Res2023
36711807Post-fast refeeding enhances intestinal stem cell-mediated regeneration and tumourigenesis through mTORC1-dependent polyamine synthesis.Res Sq2023
34780057Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.Biotechnol Bioeng2022
35443155A single-cell liver atlas of Plasmodium vivax infection.Cell Host Microbe2022
35472731Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors.Transl Oncol2022
34785582Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker.Clin Cancer Res2022
33933073Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.Microb Cell Fact2021
33880471Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii.bioRxiv2021
33766983<i>RAD21</i> is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress.Genes Dev2021
33589614Identification of a long non-coding RNA regulator of liver carcinoma cell survival.Cell Death Dis2021
33688647Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.bioRxiv2021
34818534Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade.Cell Rep2021
34493582Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.Proc Natl Acad Sci U S A2021
32786350Identifying Improved Sites for Heterologous Gene Integration Using ATAC-seq.ACS Synth Biol2020
31855834In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation.Mol Ther Nucleic Acids2020
31825599Host-Informed Expression of CRISPR Guide RNA for Genomic Engineering in <i>Komagataella phaffii</i>.ACS Synth Biol2020
31654411Comparative genome-scale analysis of Pichia pastoris variants informs selection of an optimal base strain.Biotechnol Bioeng2020
31852835Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.Clin Cancer Res2020
31792422Identification and local delivery of vasodilators for the reduction of ureteral contractions.Nat Biomed Eng2020
32632008The environmental stress response causes ribosome loss in aneuploid yeast cells.Proc Natl Acad Sci U S A2020
31085648Aneuploidy drives lethal progression in prostate cancer.Proc Natl Acad Sci U S A2019
30305426XBP1s activation can globally remodel N-glycan structure distribution patterns.Proc Natl Acad Sci U S A2018
30222731Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.PLoS Biol2018
30295421SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.Aging Cell2018
28327460Comprehensive proteomic characterization of stem cell-derived extracellular matrices.Biomaterials2017
26163349The extracellular matrix: Tools and insights for the "omics" era.Matrix Biol2016
27681084Erratum to: Comparative genomics and transcriptomics of Pichia pastoris.BMC Genomics2016
27495311Comparative genomics and transcriptomics of Pichia pastoris.BMC Genomics2016
26811325Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.Cancer Discov2016
26341558Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.Genes Dev2015
25037231Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.BMC Cancer2014
25197050Single cell sequencing reveals low levels of aneuploidy across mammalian tissues.Proc Natl Acad Sci U S A2014
23523371Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.Mol Cell2013
23873940Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.Genes Dev2013
24009526Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery.PLoS Genet2013
23630078Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.Genes Dev2013
22020333Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.Oncogene2012
21466802Essential roles of fibronectin in the development of the left-right embryonic body plan.Dev Biol2011
21987724Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.Cancer Res2011
21764851Nuclear factor I/B is an oncogene in small cell lung cancer.Genes Dev2011
21471965Suppression of lung adenocarcinoma progression by Nkx2-1.Nature2011
20018620Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors.J Immunol2010
21107428Stage-specific sensitivity to p53 restoration during lung cancer progression.Nature2010
20837522Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.Proc Natl Acad Sci U S A2010
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Collaborators

Richard O Hynes
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Co-authored papers 14
Tyler Jacks
Co-authored papers 7
Jean L Chang
Co-authored papers 4
Bruce W Birren
Broad Institute of MIT and Harvard
Co-authored papers 4
David B Jaffe
Co-authored papers 4
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 4
Michael C Zody
Broad Institute of Harvard and MIT
Co-authored papers 4
Toby Bloom
Co-authored papers 4
Chad Nusbaum
Co-authored papers 4
Manuel Garber
Co-authored papers 4
Andrew Zimmer
Co-authored papers 4
Monte M Winslow
Stanford University School of Medicine
Co-authored papers 4
David DeCaprio
Broad Institute of Harvard and MIT
Co-authored papers 4
Matthew Meyerson
Broad Institute
Co-authored papers 3
Huiming Ding
Massachusetts Institute of Technology
Co-authored papers 3
Robert Langer
Co-authored papers 3
Alexandra Naba
College of Medicine, University of Illinois at Chicago
Co-authored papers 3
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 3
David E Housman
Co-authored papers 3
Chinnappa D Kodira
GE Global Research Center
Co-authored papers 3
Karl R Clauser
Co-authored papers 3
Daniel G Anderson
Co-authored papers 3
Jennifer Hall
Co-authored papers 3
Terry Gaasterland
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 2
Roman L Bogorad
Co-authored papers 2
Caroline C Kim
Tufts Medical Center
Co-authored papers 2
Harry Kleanthous
Co-authored papers 2
Dan H Barouch
Co-authored papers 2
Lauren Carter
Co-authored papers 2
David M Feldser
Co-authored papers 2
Release 1.2