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Author Details

Jalila Chagraoui
Institute for Research in Immunology and Cancer, University of Montreal
2000
40
25
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37729615CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.Blood Adv2024
37161072Towards clinically meaningful expansion of human HSCs.Cell Res2023
35286394CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.Blood Adv2022
35797243HMGA2 expression defines a subset of human AML with immature transcriptional signature and vulnerability to G2/M inhibition.Blood Adv2022
33022376UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections.Transplant Cell Ther2021
33692124Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair.Proc Natl Acad Sci U S A2021
34499717HLF expression defines the human hematopoietic stem cell state.Blood2021
33417871UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.Cell Stem Cell2021
31704264Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.Lancet Haematol2020
31219578A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.Nucleic Acids Res2019
31703090UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.PLoS One2019
31340144Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.Cell Rep2019
29550835Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.Leukemia2018
30101153UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.Mol Ther Methods Clin Dev2018
28855157<i>H3</i><sup><i>K27M/I</i></sup> mutations promote context-dependent transformation in acute myeloid leukemia with <i>RUNX1</i> alterations.Blood2017
28408459EPCR expression marks UM171-expanded CD34<sup>+</sup> cord blood stem cells.Blood2017
28754713<i>UBAP2L</i> is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.FASEB J2017
28855357Chemogenomic Landscape of <i>RUNX1</i>-mutated AML Reveals Importance of <i>RUNX1</i> Allele Dosage in Genetics and Glucocorticoid Sensitivity.Clin Cancer Res2017
27797342High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.J Clin Invest2016
25843717E4F1 is a master regulator of CHK1-mediated functions.Cell Rep2015
25185265UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.Blood2014
25237102Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.Science2014
23777767RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.Blood2013
22174158Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2.Blood2012
22802335Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia.Blood2012
22508837A role for GPx3 in activity of normal and leukemia stem cells.J Exp Med2012
22431509A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia.Genes Dev2012
21402923An anticlastogenic function for the Polycomb Group gene Bmi1.Proc Natl Acad Sci U S A2011
20522713A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations.Blood2010
21170304Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.PLoS Genet2010
19379700A functional screen to identify novel effectors of hematopoietic stem cell activity.Cell2009
18617424The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.Immunity2008
19022763Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.Cold Spring Harb Symp Quant Biol2008
17577929Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.Exp Hematol2007
16195330Expression of Pitx2 in stromal cells is required for normal hematopoiesis.Blood2006
16882984E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.Genes Dev2006
14630797Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells.Blood2004
12506029Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition.Blood2003
12423679Forced expression of p21 in GPIIb-p21 transgenic mice induces abnormalities in the proliferation of erythroid and megakaryocyte progenitors and primitive hematopoietic cells.Exp Hematol2002
11090058Ontogenic emergence of the hematon, a morphogenetic stromal unit that supports multipotential hematopoietic progenitors in mouse bone marrow.Blood2000
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Collaborators

Guy Sauvageau
Universite de Montreal
Co-authored papers 35
Marie-Jos??e H??bert
Universite de Montreal
Co-authored papers 11
Jana Krosl
The Leucegene Project at Institute for Research in Immunology and Cancer.
Co-authored papers 8
Anne Marinier
Institute for Research in Immunology and Cancer
Co-authored papers 7
Iman Fares
Dana-Farber Cancer Institute
Co-authored papers 6
Sylvain Meloche
Institute for Research in Immunology and Cancer
Co-authored papers 5
Philippe P Roux
IRIC - University of Montreal
Co-authored papers 4
Denis-Claude Roy
Universite de Montreal
Co-authored papers 3
Patrick Gendron
University of Montreal
Co-authored papers 3
Peter W Zandstra
Co-authored papers 2
Paul S Maddox
University of North Carolina at Chapel Hill
Co-authored papers 2
L??o Aubert
IRIC - University of Montreal
Co-authored papers 2
Mathieu Tremblay
Universite de Montreal, Institute for Research in Immunology and Cancer
Co-authored papers 1
Veronique Litalien
Walter and Eliza Hall Institute of Medical Research
Co-authored papers 1
Bastien Gerby
Universite de Toulouse, Inserm, Universite Toulouse III-Paul Sabatier
Co-authored papers 1
Diogo F T Veiga
University of Campinas (UNICAMP)
Co-authored papers 1
Genevi??ve Lavoie
Institute for Research in Immunology and Cancer (IRIC)
Co-authored papers 1
Milena Kosic
Leslie Dan Faculty of Pharmacy and Department of Biochemistry, University of Toronto
Co-authored papers 1
Jasmin Coulombe-Huntington
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 1
Sami Nourreddine (CM4AI)
University of California San Diego
Co-authored papers 1
Julianne Ouellette
Co-authored papers 1
Elizabeth Ottoni
Universite de Montreal
Co-authored papers 1
Trang Hoang
Department of Biomedical Science and Center for Bio-Nanomaterials, Daegu University
Co-authored papers 1
Joel Ryan
McGill University
Co-authored papers 1
Simon Drouin
Centre Hospitalier Universitaire Sainte-Justine
Co-authored papers 1
Dominique Geoffrion
Centre hospitalier universitaire de l'Universite de Montreal (CHUM)
Co-authored papers 1
Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 1
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Grant W Brown
University of Toronto, 1 King's College Circle
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Release 1.2