Author details

Full Name

Renate Kirschner-Schwabe

Affiliation

ORCID

Career Start Year

1997

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35243242	The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia.	iScience	2022
35585141	Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.	Leukemia	2022
34757015	Advanced Minimal Residual Disease Monitoring for Acute Lymphoblastic Leukemia with Multiplex Mediator Probe PCR.	Journal of Molecular Diagnostics	2022
35122027	Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse.	Nat Cancer	2021
34010787	Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials.	Eur J Cancer	2021
33580201	Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome.	Leukemia	2021
32755029	Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors.	EMBO Mol Med	2020
31971569	Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.	Blood	2020
30714092	Aneuploidy in children with relapsed B-cell precursor acute lymphoblastic leukaemia: clinical importance of detecting a hypodiploid origin of relapse.	British Journal of Haematology	2019
31644328	Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics.	J Clin Oncol	2019
30642353	Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia.	J Hematol Oncol	2019
30862934	Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures.	Sci Rep	2019
29342136	Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.	Nature	2018
30389682	PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia.	EMBO Mol Med	2018
29990496	Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.	Cancer Cell	2018
29489754	The landscape of genomic alterations across childhood cancers.	Nature	2018
28157215	Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.	Blood Cancer J	2017
28360149	mutation, alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia.	Haematologica	2017
29296789	Intragenic amplification of <i>PAX5</i>: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?	Blood Adv	2017
27655895	Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.	Proc Natl Acad Sci U S A	2016
26294725	Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.	Haematologica	2015
25962120	Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.	Nat Med	2015
25253770	Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition.	Blood	2014
24045615	Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.	Hum Mol Genet	2014
24972766	The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.	Haematologica	2014
23377281	Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.	Nat Med	2013
22699455	Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia.	Leukemia	2013
21546902	Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment.	Leukemia	2011
21747090	Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia.	Journal of Clinical Oncology	2011
21828124	High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse.	Haematologica	2011
21863532	[Maternal obesity and life-style factors in pregnancy].	Zeitschrift fur Geburtshilfe und Neonatologie	2011
20228269	CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia.	Blood	2010
21031330	[Management of dichorionic twin delivery at term with cephalic-presenting first twin - a monocentric retrospective cohort study].	Zeitschrift fur Geburtshilfe und Neonatologie	2010
20007830	Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds.	Investigative Ophthalmology and Visual Science	2010
19424578	Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.	Int J Oncol	2009
19480934	Somatic mitochondrial mutations in pilocytic astrocytoma.	Cancer Genetics and Cytogenetics	2009
18552978	Identification of novel mutations in X-linked retinitis pigmentosa families and implications for diagnostic testing.	Mol Vis	2008
17219391	Prenatal manifestation of pancytopenia in Pearson marrow-pancreas syndrome caused by a mitochondrial DNA deletion.	American Journal of Medical Genetics, Part A	2007
17330098	Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.	Leukemia	2007
16899601	Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia.	Clin Cancer Res	2006
15075239	Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.	Journal of Cell Science	2004
12961103	[Psychosocial stress as a risk factor for preterm birth--first results of the BabyCare project].	Zentralblatt fur Gynakologie	2003
11371505	Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency.	Human Molecular Genetics	2001
11702207	DNA sequence comparison of human and mouse retinitis pigmentosa GTPase regulator (RPGR) identifies tissue-specific exons and putative regulatory elements.	Human Genetics	2001
10401007	RPGR transcription studies in mouse and human tissues reveal a retina-specific isoform that is disrupted in a patient with X-linked retinitis pigmentosa.	Human Molecular Genetics	1999
9617012	[Physician practice patterns and attitudes to euthanasia in Germany. A representative survey of physicians].	Gesundheitswesen	1998
9697692	Positional cloning of the gene for X-linked retinitis pigmentosa 2.	Nature Genetics	1998
9073514	The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.	Genomics	1997
9373155	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	Gene	1997