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Author Details

Robert M Stroud
University of California San Francisco
1965
358
89
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36747776Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.bioRxiv2023
36965620Substrate recognition and proton coupling by a bacterial member of solute carrier family 17.J Biol Chem2023
36782050Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.Nat Struct Mol Biol2023
34964607Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.Biochemistry2022
35660266Diversity of function and mechanism in a family of organic anion transporters.Curr Opin Struct Biol2022
36475542Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.Elife2022
35210362Molecular basis of multistep voltage activation in plant two-pore channel 1.Proc Natl Acad Sci U S A2022
34135124Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT.Proc Natl Acad Sci U S A2021
33829766Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.Biochemistry2021
33744283Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.J Biol Chem2021
33876770Structural basis for <i>Clostridium perfringens</i> enterotoxin targeting of claudins at tight junctions in mammalian gut.Proc Natl Acad Sci U S A2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
34319067Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody.Biochemistry2021
32380514Diversity in kinetics correlated with structure in nano body-stabilized LacY.PLoS One2020
31924746Resting state structure of the hyperdepolarization activated two-pore channel 3.Proc Natl Acad Sci U S A2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
32439795Ion transport and regulation in a synaptic vesicle glutamate transporter.Science2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
31083648Structures suggest a mechanism for energy coupling by a family of organic anion transporters.PLoS Biol2019
31267462High-Throughput Nano-Scale Characterization of Membrane Proteins Using Fluorescence-Detection Size-Exclusion Chromatography.Methods Mol Biol2019
31434788Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.Proc Natl Acad Sci U S A2019
31149896Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.Elife2019
28656706On the structure and mechanism of two-pore channels.FEBS J2018
30166453CRL4<sup>AMBRA1</sup> targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.EMBO J2018
30190435Structural basis for activation of voltage sensor domains in an ion channel TPC1.Proc Natl Acad Sci U S A2018
30108145Crystal Structure of a ligand-bound LacY-Nanobody Complex.Proc Natl Acad Sci U S A2018
29717875A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.Biochemistry2018
28069938Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.Proc Natl Acad Sci U S A2017
27078104Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.Proc Natl Acad Sci U S A2016
27692964The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.Structure2016
27601653Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers.Proc Natl Acad Sci U S A2016
27129281Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.J Biol Chem2016
27485338Small-Scale Screening to Large-Scale Over-Expression of Human Membrane Proteins for Structural Studies.Methods Mol Biol2016
27485336Integral Membrane Protein Expression in Saccharomyces cerevisiae.Methods Mol Biol2016
26961658Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana.Nature2016
25363761Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter.Nature2015
26528243Fungal association and utilization of phosphate by plants: success, limitations, and future prospects.Front Microbiol2015
26470919Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.J Mol Biol2015
26157133Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site.Proc Natl Acad Sci U S A2015
25865481Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.Cell2015
25798950Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.J Med Chem2015
25427005Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.J Med Chem2015
24214967The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.Nucleic Acids Res2014
24994900Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi.Proc Natl Acad Sci U S A2014
25081745General qPCR and Plate Reader Methods for Rapid Optimization of Membrane Protein Purification and Crystallization Using Thermostability Assays.Curr Protoc Protein Sci2014
25081744Tetra detector analysis of membrane proteins.Curr Protoc Protein Sci2014
24613931Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.Proc Natl Acad Sci U S A2014
24453216Structure of sugar-bound LacY.Proc Natl Acad Sci U S A2014
23542591Crystal structure of a eukaryotic phosphate transporter.Nature2013
24173033Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter.Proc Natl Acad Sci U S A2013
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Collaborators

University of California San Francisco
Co-authored papers 77
University of California San Francisco
Co-authored papers 37
University of California san francisco
Co-authored papers 18
Department of Pharmaceutical Chemistry, University of California-San Francisco
Co-authored papers 17
University of California San Francisco
Co-authored papers 13
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 13
University of California san francisco
Co-authored papers 10
University of California berkeley
Co-authored papers 9
University of Washington
Co-authored papers 8
University of California san francisco
Co-authored papers 8
Co-authored papers 7
University of Oklahoma Health Sciences Center
Co-authored papers 7
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 7
Pfizer Inc.
Co-authored papers 7
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 7
University of California San Francisco
Co-authored papers 6
University of California san francisco
Co-authored papers 6
University of California los angeles
Co-authored papers 5
University of California Berkeley
Co-authored papers 5
Bennett University
Co-authored papers 5
Aarhus University
Co-authored papers 5
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Center for the Structure of Membrane Proteins, University of California san francisco
Co-authored papers 5
University of California San Francisco
Co-authored papers 5
Sher-i-Kashmir Institute of Medical Sciences
Co-authored papers 5
University of California san francisco
Co-authored papers 5
University of Virginia
Co-authored papers 4
J. David Gladstone Institutes
Co-authored papers 4
University of California
Co-authored papers 4
Albert Einstein College of Medicine
Co-authored papers 4