Author details

Full Name

Michael R Botchan

Affiliation

University of California berkeley

ORCID

Career Start Year

1970

Papers

144

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34951585	Molecular determinants of phase separation for <i>Drosophila</i> DNA replication licensing factors.	Elife	2021
33784179	Structural Mechanisms for Replicating DNA in Eukaryotes.	Annu Rev Biochem	2021
31484077	Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.	Cell Rep	2019
31560342	A new class of disordered elements controls DNA replication through initiator self-assembly.	Elife	2019
29899147	Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.	Proc Natl Acad Sci U S A	2018
28912235	Not just Salk.	Science	2017
28209641	Mechanisms for initiating cellular DNA replication.	Science	2017
28094588	Mechanisms and regulation of DNA replication initiation in eukaryotes.	Crit Rev Biochem Mol Biol	2017
25561522	Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.	Proc Natl Acad Sci U S A	2015
25965754	CRISPR germline engineering--the community speaks.	Nat Biotechnol	2015
25791083	Biotechnology. A prudent path forward for genomic engineering and germline gene modification.	Science	2015
25762138	Crystal structure of the eukaryotic origin recognition complex.	Nature	2015
25117490	DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.	Elife	2014
25249635	Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.	Proc Natl Acad Sci U S A	2014
23881943	The minichromosome maintenance replicative helicase.	Cold Spring Harb Perspect Biol	2013
24137536	A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.	Elife	2013
22853956	Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.	Proc Natl Acad Sci U S A	2012
22688510	Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.	Mol Cell Biol	2012
22778422	ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote.	Proc Natl Acad Sci U S A	2012
21362550	Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.	Mol Cell	2011
22028662	Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition.	PLoS Genet	2011
21378962	The structural basis for MCM2-7 helicase activation by GINS and Cdc45.	Nat Struct Mol Biol	2011
20122406	Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.	Mol Cell	2010
21172652	DNA replication: making two forks from one prereplication complex.	Mol Cell	2010
20448167	Climate change and the integrity of science.	Science	2010
20599892	Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes.	Dev Biol	2010
18824234	Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping.	J Struct Biol	2008
17230184	Cell biology: a switch for S phase.	Nature	2007
17978103	Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.	Genes Dev	2007
17403774	Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.	Genes Dev	2007
16829958	Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.	Nat Struct Mol Biol	2006
17189190	Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association.	Mol Cell	2006
16798881	Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.	Proc Natl Acad Sci U S A	2006
15854909	humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila.	Curr Biol	2005
16188887	CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex.	J Biol Chem	2005
15109488	Hitchhiking without covalent integration.	Cell	2004
15545624	Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.	Genes Dev	2004
15256498	Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication.	Genes Dev	2004
15289463	The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.	Genes Dev	2004
14765124	DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding.	EMBO J	2004
14723843	A genome analysis of endoreplication in the Drosophila ovary.	Dev Cell	2004
12878722	A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity.	Proc Natl Acad Sci U S A	2003
11884568	E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.	J Virol	2002
12244108	Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase.	J Biol Chem	2002
12490953	Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.	Nature	2002
11566101	Origin recognition complex binding to a metazoan replication origin.	Curr Biol	2001
11290306	Orc mutants arrest in metaphase with abnormally condensed chromosomes.	Development	2001
11593009	Functional analysis of mutant and wild-type Drosophila origin recognition complex.	Proc Natl Acad Sci U S A	2001
10731132	The genome sequence of Drosophila melanogaster.	Science	2000
10793002	The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.	Virology	2000

1 - 50 of 144

Haiqing Fu

Center for Cancer Research, National Cancer Institute, National Institutes of Health

Career Start Year 2003

Number of shared co-authors 0

Nikita Avvakumov

Institute of Molecular and Cell Biology, University of Tartu

Career Start Year 2001

Number of shared co-authors 0

Woo S Joo

Memorial Sloan-Kettering Cancer Center

Career Start Year 1997

Number of shared co-authors 2

Matthew D Weitzman

The Children's Hospital of Philadelphia

Career Start Year 1992

Number of shared co-authors 0

Jeffrey J Delrow

Clinical Research Division, Fred Hutchinson Cancer Research Center

Career Start Year 1992

Number of shared co-authors 2

Larry D Mesner

Center for Public Health Genomics, University of Virginia

Career Start Year 1991

Number of shared co-authors 1

Alex Vassilev

National Institute of Child Health & Human Development, National Institutes of Health

Career Start Year 1991

Number of shared co-authors 0

Jacques Archambault

McGill University

Career Start Year 1990

Number of shared co-authors 0

Joe S Mymryk

University of Western Ontario

Career Start Year 1989

Number of shared co-authors 0

Mirit I Aladjem

National Cancer Institute, Center for Cancer Research

Career Start Year 1988

Number of shared co-authors 0

Tadashi Wada

Osaka University

Career Start Year 1987

Number of shared co-authors 0

Monika Tsai-Pflugfelder

Friedrich Miescher Institute for Biomedical Research

Career Start Year 1984

Number of shared co-authors 0

Ivan Sadowski

University of British Columbia

Career Start Year 1984

Number of shared co-authors 1

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Career Start Year 1984

Number of shared co-authors 0

James T Kadonaga

University of California

Career Start Year 1983

Number of shared co-authors 8

Stephen J Elledge

Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School

Career Start Year 1982

Number of shared co-authors 5

Paul A Kitts

National Center for Biotechnology Information, National Institutes of Health

Career Start Year 1982

Number of shared co-authors 20

Danny Reinberg

HHMI/NYU Langone School of Medicine

Career Start Year 1980

Number of shared co-authors 1

Dirk Eick

Helmholtz Center Munich and Center for Integrated Protein Science Munich (CIPSM)

Career Start Year 1980

Number of shared co-authors 0

Kalappa Muniyappa

Indian Institute of Science

Career Start Year 1979

Number of shared co-authors 0

Jef D Boeke

Institute for Systems Genetics, NYU School of Medicine

Career Start Year 1978

Number of shared co-authors 3

Adrian Francis Stewart

Center for Molecular and Cellular Bioengineering, Technische Universitat Dresden

Career Start Year 1976

Number of shared co-authors 1

Steven Hayward

Johns Hopkins University School of Medicine

Career Start Year 1973

Number of shared co-authors 0

Stephen P Goff

Columbia University

Career Start Year 1973

Number of shared co-authors 1

Richard D Kolodner

Ludwig Institute for Cancer Research San Diego Branch

Career Start Year 1972

Number of shared co-authors 2

Robert G Roeder

the Rockefeller University

Career Start Year 1969

Number of shared co-authors 0

Jack F Greenblatt

College Street, University of Toronto

Career Start Year 1969

Number of shared co-authors 4

Tom Maniatis

College des medecins du Quebec

Career Start Year 1968

Number of shared co-authors 1

Arnold J Levine

Simons Center for Systems Biology, Institute for Advanced Study

Career Start Year 1967

Number of shared co-authors 96

Roger D Kornberg

Stanford University

Career Start Year 1965

Number of shared co-authors 2

row(s) 1 - 30 of 30

Rong Li

University of Texas Health

Co-authored papers 10

James J Pesavento

Saint Mary's College of California

Co-authored papers 3

Daniel A Lim

University of California san francisco

Co-authored papers 3

Jacob E Corn

Co-authored papers 2

Jennifer A Doudna

Innovative Genomics Institute, University of California berkeley

Co-authored papers 2

J C Venter

The J. Craig Venter Institute

Co-authored papers 2

Henry T Greely

The Center for Law and the Biosciences, Stanford University

Co-authored papers 2

R Alta Charo

University of Wisconsin-Madison/Nuclear Threat Initiative

Co-authored papers 2

Paul D Robbins

University of Minnesota

Co-authored papers 2

Donald C Rio

University of California berkeley

Co-authored papers 2

Pamela J Bjorkman

Co-authored papers 2

Allan C Spradling

Carnegie Institution for Science/Howard Hughes Medical Institute

Co-authored papers 2

Michael B Eisen

Howard Hughes Medical Institute, University of California Berkeley

Co-authored papers 1

Simon A Levin

Co-authored papers 1

Peter Li

Co-authored papers 1

Mark Yandell

University of Utah

Co-authored papers 1

Shannon Dugan

Baylor College of Medicine

Co-authored papers 1

Carlos C Evangelista

Co-authored papers 1

Yong Liang

Michigan State University

Co-authored papers 1

Michael P McLeod

Life Sciences Institute, University of British Columbia

Co-authored papers 1

Eli Venter

Vanderbilt University, Columbia University Medical Center

Co-authored papers 1

Stephen P Jackson

Mission Therapeutics Ltd. Glenn Berge Building

Co-authored papers 1

Dana Busam

J. Craig Venter Institute

Co-authored papers 1

N V Mil'shina

Co-authored papers 1

Mike Palazzolo

Washington University School of Medicine

Co-authored papers 1

Robin Lovell-Badge

The Francis Crick Institute

Co-authored papers 1

Joan S Brugge

Co-authored papers 1

A Agbayani

Co-authored papers 1

Inga Siden-Kiamos

Institute of Molecular Biology and Biotechnology

Co-authored papers 1

H R Kaback

University of California los angeles

Co-authored papers 1

1 - 30

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