Author details

Full Name

Michael J Keiser

Affiliation

Institute for Neurodegenerative Diseases, University of California san francisco

ORCID

Career Start Year

2007

Papers

H Index

Expertise

CM4AI Collaborator

Trey Ideker (CM4AI)

PMID	Paper Title	Journal Title	Published Year
36759942	The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information.	Bioinformatics	2023
37693536	Learning chemical sensitivity reveals mechanisms of cellular response.	bioRxiv	2023
38045231	ChromaFactor: deconvolution of single-molecule chromatin organization with non-negative matrix factorization.	bioRxiv	2023
37868032	<i>In silico</i> discovery of repetitive elements as key sequence determinants of 3D genome folding.	Cell Genom	2023
37355729	Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.	Commun Biol	2023
36711704	Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.	bioRxiv	2023
36093122	A biomedical open knowledge network harnesses the power of AI to understand deep human biology.	AI Mag	2022
35484610	Deep learning from multiple experts improves identification of amyloid neuropathologies.	Acta Neuropathol Commun	2022
36276634	Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics.	Nat Mach Intell	2022
36102784	Prioritizing Virtual Screening with Interpretable Interaction Fingerprints.	J Chem Inf Model	2022
33479460	Stress testing reveals gaps in clinic readiness of image-based diagnostic artificial intelligence models.	NPJ Digit Med	2021
32345363	Validation of machine learning models to detect amyloid pathologies across institutions.	Acta Neuropathol Commun	2020
33245237	Adding Stochastic Negative Examples into Machine Learning Improves Molecular Bioactivity Prediction.	J Chem Inf Model	2020
32586194	Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain.	Mol Pain	2020
32366098	Learning Molecular Representations for Medicinal Chemistry.	J Med Chem	2020
32229141	Artificial Intelligence in Dermatology: A Primer.	J Invest Dermatol	2020
31092819	Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline.	Nat Commun	2019
31501447	Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.	Nat Commun	2019
29193970	Predicted Biological Activity of Purchasable Chemical Space.	J Chem Inf Model	2018
30053424	The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.	Cell	2018
30336670	Adversarial Controls for Scientific Machine Learning.	ACS Chem Biol	2018
30442776	Comment on "Predicting reaction performance in C-N cross-coupling using machine learning".	Science	2018
28731335	A Simple Representation of Three-Dimensional Molecular Structure.	J Med Chem	2017
29091768	Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior.	Cell Rep	2017
26845413	Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.	ACS Chem Biol	2016
27239787	Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.	Nat Chem Biol	2016
26915512	Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.	Lancet Psychiatry	2016
25670520	Systems pharmacology augments drug safety surveillance.	Clin Pharmacol Ther	2015
26335661	Prediction and validation of enzyme and transporter off-targets for metformin.	J Pharmacokinet Pharmacodyn	2015
24260022	In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.	PLoS Biol	2013
22722194	Large-scale prediction and testing of drug activity on side-effect targets.	Nature	2012
21048700	The presynaptic component of the serotonergic system is required for clozapine's efficacy.	Neuropsychopharmacology	2011
22179068	Chemical informatics and target identification in a zebrafish phenotypic screen.	Nat Chem Biol	2011
20180535	Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.	J Med Chem	2010
21058655	The chemical basis of pharmacology.	Biochemistry	2010
20540517	Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.	J Med Chem	2010
20581797	A pilot study of the pharmacodynamic impact of SSRI drug selection and beta-1 receptor genotype (ADRB1) on cardiac vital signs in depressed patients: a novel pharmacogenetic approach.	Psychopharmacol Bull	2010
19483698	Quantifying biogenic bias in screening libraries.	Nat Chem Biol	2009
19881490	Predicting new molecular targets for known drugs.	Nature	2009
19701464	A mapping of drug space from the viewpoint of small molecule metabolism.	PLoS Comput Biol	2009
19727616	Off-target networks derived from ligand set similarity.	Methods Mol Biol	2009
18335977	Quantifying the relationships among drug classes.	J Chem Inf Model	2008
17287757	Relating protein pharmacology by ligand chemistry.	Nat Biotechnol	2007

1 - 43 of 43

Neel S Madhukar

Weill Cornell Medical College

Career Start Year 2015

Number of shared co-authors 0

Zhaoping Xiong

Huawei Cloud Computing Technologies Co.

Career Start Year 2014

Number of shared co-authors 0

Minji Jeon

Korea University College of Medicine

Career Start Year 2014

Number of shared co-authors 1

Adam S Brown

Broad Institute of MIT and Harvard

Career Start Year 2013

Number of shared co-authors 0

Wail Ba-Alawi

Princess Margaret Cancer Centre, University Health Network, University Ave.

Career Start Year 2013

Number of shared co-authors 0

Matthew K Matlock

Washington University in St. Louis

Career Start Year 2012

Number of shared co-authors 0

Bin Chen

Jiangsu University

Career Start Year 2009

Number of shared co-authors 1

Artem Sokolov

Harvard Medical School

Career Start Year 2006

Number of shared co-authors 1

Ola Spjuth

Department of Pharmaceutical Biosciences, Uppsala University

Career Start Year 2006

Number of shared co-authors 0

Yang Shen

The Second Affiliated Hospital of Nanchang University

Career Start Year 2006

Number of shared co-authors 0

Sanjay J Swamidass

Washington University School of Medicine

Career Start Year 2005

Number of shared co-authors 1

Rajarshi Guha

Vertex Pharmaceuticals

Career Start Year 2004

Number of shared co-authors 2

Anang A Shelat

St. Jude Children's Research Hospital

Career Start Year 2003

Number of shared co-authors 2

Assaf Gottlieb

Center for Precision Health, University of Texas Health Science Center at Houston

Career Start Year 2002

Number of shared co-authors 1

Scott Boyer

Swedish Toxicology Sciences Research Center, Karolinska Institutet

Career Start Year 2002

Number of shared co-authors 2

Gerald H Lushington

Inc. 16 Dekalb Pike

Career Start Year 2002

Number of shared co-authors 0

Noel Southall

National Center for Advancing Translational Sciences, National Institutes of Health

Career Start Year 2002

Number of shared co-authors 3

Anna Gaulton

European Bioinformatics Institute (EMBL-EBI)

Career Start Year 2002

Number of shared co-authors 5

Tero Aittokallio

Institute for Molecular Medicine Finland (FIMM), University of Helsinki

Career Start Year 1999

Number of shared co-authors 1

Paul A Clemons

Broad Institute

Career Start Year 1999

Number of shared co-authors 4

Stephan C Sch??rer

Institute for Data Science and Computing, University of Miami

Career Start Year 1998

Number of shared co-authors 4

Tomislav ??muc

Ruder Boskovic Institute

Career Start Year 1998

Number of shared co-authors 1

Vlado Dan????k

Broad Institute

Career Start Year 1997

Number of shared co-authors 2

Bissan Al-Lazikani

The University of Texas MD Anderson Cancer Center

Career Start Year 1997

Number of shared co-authors 1

Cristian G Bologa

University of New Mexico School of Medicine

Career Start Year 1995

Number of shared co-authors 3

Andrew L Hopkins

University of Dundee

Career Start Year 1995

Number of shared co-authors 4

Arya Ajay

National Center for Advancing Translational Science, 9800 Medical Center Drive

Career Start Year 1993

Number of shared co-authors 2

Christopher P Austin

St. George's University Medical School

Career Start Year 1990

Number of shared co-authors 5

John P Overington

Institute of Cardiovascular Science, University College London

Career Start Year 1988

Number of shared co-authors 4

Russ B Altman

Stanford University

Career Start Year 1982

Number of shared co-authors 11

row(s) 1 - 30 of 30

Brian K Shoichet

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 13

John J Irwin

Department of Pharmaceutical Chemistry, University of California san francisco

Co-authored papers 9

Bryan L Roth

UNC Chapel Hill School of Medicine

Co-authored papers 7

Brittany N Dugger

University of California davis

Co-authored papers 5

Vincent Setola

West Virginia University School of Medicine

Co-authored papers 3

Charles DeCarli

University of California Davis

Co-authored papers 3

Xi-Ping Huang

University of North Carolina School of Medicine

Co-authored papers 3

Atul J Butte

Bakar Computational Health Sciences Institute, University of California san francisco

Co-authored papers 2

Edwin S Monuki

University of California, University of California Irvine

Co-authored papers 2

Karthik Soman

Weill Institute for Neuroscience, University of California - San Francisco

Co-authored papers 2

Sergio E Baranzini

University of California san francisco

Co-authored papers 2

Mark A Musen

Stanford Center for Biomedical Informatics Research, Stanford University

Co-authored papers 2

Tomasz J Nowakowski

University of California san francisco

Co-authored papers 1

Nevan J Krogan (CM4AI)

University of California San Francisco

Co-authored papers 1

Graeme W Davis

Kavli Institute for Fundamental Neuroscience, University of California san francisco

Co-authored papers 1

Daniel L Minor

Cardiovascular Research Institute, University of California san francisco

Co-authored papers 1

David A Agard

University of California, USA Quantitative Biosciences Institute (QBI) san francisco

Co-authored papers 1

Vikaas S Sohal

University of California san francisco

Co-authored papers 1

Li Gan

Helen and Robert Appel Alzheimer's Disease Research Institute

Co-authored papers 1

Susumu Tomita

Co-authored papers 1

Mark von Zastrow

University of California san francisco

Co-authored papers 1

Sourav Bandyopadhyay

University of California San Francisco

Co-authored papers 1

Allison K Doak

Department of Pharmaceutical Chemistry, University of California San Francisco

Co-authored papers 1

Lawrence Lin

University of California San Francisco

Co-authored papers 1

Ajit Jadhav

Co-authored papers 1

Hugo J Bellen

Baylor College of Medicine

Co-authored papers 1

Ruth H??ttenhain

Quantitative Biosciences Institute (QBI), University of California san francisco

Co-authored papers 1

Shaun Purcell

Brigham and Women's Hospital

Co-authored papers 1

Mustafa K Khokha

Yale University School of Medicine

Co-authored papers 1

Nicholas P Tatonetti

Columbia Universtiy College of Physicians and Surgeons

Co-authored papers 1

1 - 30

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