Author details

Full Name

Stephen J Haggarty

Affiliation

ORCID

Career Start Year

1998

Papers

157

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37503195	Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with <i>MAPT</i> Mutations.	bioRxiv	2023
37989753	Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.		2023
37402854	Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca<sup>2+</sup> entry and accelerated differentiation.	Mol Psychiatry	2023
37043557	A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.		2023
37043533	A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.	Proc Natl Acad Sci U S A	2023
34757590	Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.	Mol Neurobiol	2022
36039764	Chemically targeting the redox switch in AP1 transcription factor Î¿FOSB.	Nucleic Acids Research	2022
35507160	Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.	Methods in Molecular Biology	2022
35505090	Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.	Mol Psychiatry	2022
35317195	Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.	Front Cell Neurosci	2022
35045295	A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.	Cell Rep	2022
34761180	Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.	iScience	2021
34077555	Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.	Journal of Neurochemistry	2021
34264955	Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.	PLoS One	2021
34314701	ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.	Cell	2021
32636474	Advances toward precision medicine for bipolar disorder: mechanisms & molecules.	Mol Psychiatry	2021
34549949	Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins.	Journal of Medicinal Chemistry	2021
34426604	High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.	Sci Rep	2021
30990190	Deep Learning Benchmarks on L1000 Gene Expression Data.	IEEE/ACM Trans Comput Biol Bioinform	2020
32320910	Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.	Nuclear Medicine and Biology	2020
31825616	Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.	Journal of Medicinal Chemistry	2020
31988434	A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.	Mol Psychiatry	2020
32094324	Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.	Transl Psychiatry	2020
31921404	TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.	Molecular Autism	2020
31808609	Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia.	EMBO Rep	2020
32990597	Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.	eLife	2020
33255694	Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.	International Journal of Molecular Sciences	2020
33253521	Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3Î²) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.	ACS Chem Neurosci	2020
32591533	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.	Nature Communications	2020
33083513	Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.	Alzheimer's and Dementia: Translational Research and Clinical Interventions	2020
30875083	Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.	Annals of the New York Academy of Sciences	2020
31535859	Structural Basis for Achieving GSK-3Î² Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.	J Med Chem	2019
31599282	Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.	Chemical Communications	2019
31783699	An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.	Cells	2019
30510257	Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.	Nat Med	2019
30530989	PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.	J Clin Invest	2019
30573526	A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.	EMBO Rep	2019
31086815	Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo.	Science advances	2019
30918111	A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.	Sci Transl Med	2019
30907729	Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.	Elife	2019
31202891	Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).	Mol Cell Neurosci	2019
31153805	Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.	Bioorganic and Medicinal Chemistry Letters	2019
31330099	Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.	ACS Chemical Neuroscience	2019
29791859	Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.	Cell Reports	2018
28439102	MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.	Molecular Psychiatry	2018
29982664	EPH receptor signaling as a novel therapeutic target in NF2-deficient meningioma.	Neuro Oncol	2018
30510233	High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.	Nature Communications	2018
29932631	Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.	ACS Chem Neurosci	2018
30046097	Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.	Translational Psychiatry	2018
29897904	Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2.	PLoS One	2018