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Author Details

Lu-Yun Lian
Institute of Systems, The University of Liverpool
1984
139
40
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36550088Probing Peptidylprolyl Bond cis/trans Status Using Distal <sup>19</sup> F NMR Reporters.Chemistry2023
34888671CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms.J Cell Sci2022
35533445Development of chimeric forms of the matrix metalloproteinase 2 collagen binding domain as artificial membrane binding proteins for targeting stem cells to cartilage lesions in osteoarthritic joints.Biomaterials2022
35746469Co-Administration of Adjuvanted Recombinant <i>Ov</i>-103 and <i>Ov</i>-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine <i>Onchocerca ochengi</i> Infection Model of Human Onchocerciasis.Vaccines (Basel)2022
34163995Identification of β-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation.Chem Sci2021
34402867Metabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach.Biosci Rep2021
32576835Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics.Sci Rep2020
31866013Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure.Biochem Biophys Res Commun2020
31413267Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions.Sci Rep2019
29729387Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction.Insect Biochem Mol Biol2018
30229649<sup>1</sup>H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints.J Proteome Res2018
30296268Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.PLoS Negl Trop Dis2018
28662181Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor.PLoS Pathog2017
28398555Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.Hum Mol Genet2017
26950392Small Molecule Inhibitors of Cyclophilin D To Protect Mitochondrial Function as a Potential Treatment for Acute Pancreatitis.J Med Chem2016
27452402Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.Structure2016
27066458Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis.Front Oncol2016
25979333Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.J Biol Chem2015
26160844Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.Oncotarget2015
26177569Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions.Sci Rep2015
24712326Trifluoroibuprofen inhibits α-methylacyl coenzyme A racemase (AMACR/P504S), reduces cancer cell proliferation and inhibits in vivo tumor growth in aggressive prostate cancer models.Anticancer Agents Med Chem2014
25279835The structure, stability and pheromone binding of the male mouse protein sex pheromone darcin.PLoS One2014
25109970Comparative study of the molecular variation between 'central' and 'peripheral' MUPs and significance for behavioural signalling.Biochem Soc Trans2014
25188201Demonstration of binding of neuronal calcium sensor-1 to the cav2.1 p/q-type calcium channel.Biochemistry2014
23288833Cooperative catalysis through noncovalent interactions.Angew Chem Int Ed Engl2013
23890519A report of 2 new cases of MODY2 and review of the literature: implications in the search for type 2 diabetes drugs.Metabolism2013
23895101Structure-based design of PDZ ligands as inhibitors of 5-HT(2A) receptor/PSD-95 PDZ1 domain interaction possessing anti-hyperalgesic activity.ACS Chem Biol2013
23929631Inhibition of human α-methylacyl CoA racemase (AMACR): a target for prostate cancer.ChemMedChem2013
23611315NMR studies of weak protein-protein interactions.Prog Nucl Magn Reson Spectrosc2013
23545111Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents.Bioorg Med Chem Lett2013
23274113Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.J Mol Biol2013
22140111The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.Nucleic Acids Res2012
23028322Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.PLoS Pathog2012
22989873Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7: a regulator of golgi trafficking.J Biol Chem2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
22848679NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.PLoS One2012
22483112Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling.Structure2012
22480236Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies.Mol Pharm2012
22644296Splice variant PRKC-ζ(-PrC) is a novel biomarker of human prostate cancer.Br J Cancer2012
22242544Conformational characterization of synapse-associated protein 97 by nuclear magnetic resonance and small-angle X-ray scattering shows compact and elongated forms.Biochemistry2012
20703835The 1H, 13C and 15N backbone and side-chain assignment of the RRM domain of SC35, a regulator of pre-mRNA splicing.Biomol NMR Assign2011
22114693Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1.PLoS One2011
21530246NMR evaluation of interactions between substituted-indole and PDZ1 domain of PSD-95.Bioorg Med Chem Lett2011
21655236Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits.PLoS One2011
21324359Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed.Insect Biochem Mol Biol2011
19797610Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries.Drug Metab Dispos2010
21779455PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.Genes Cancer2010
207038361H, 15N and 13C resonance assignment of darcin, a mouse major urinary protein.Biomol NMR Assign2010
20479890Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder.PLoS One2010
19032153Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Biochem J2009
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Collaborators

Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 37
Alexander P Golovanov
The University of Manchester
Co-authored papers 15
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 12
Guillaume M Hautbergue
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield
Co-authored papers 9
Colin Kleanthous
Co-authored papers 5
Robert J Beynon
Co-authored papers 3
Jane L Hurst
Co-authored papers 3
C Jeremy Craven
University of Sheffield
Co-authored papers 3
Christopher S Foster
The Institute of Cancer Research
Co-authored papers 2
Colin S Cooper
Norwich Medical School, University of East Anglia
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Matthew P Crump
University of Bristol
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mike P Williamson
The University of Sheffield
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Stephen Matthews
Imperial College London
Co-authored papers 1
Chien Ho
Carnegie Mellon University
Co-authored papers 1
Toshimichi Fujiwara
Institute for Protein Research, Osaka University
Co-authored papers 1
Pei Tang
Sichuan University
Co-authored papers 1
Joern Werner
Co-authored papers 1
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 1
Release 1.2