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Author Details

Theresa M LaVallee
Parker Institute for Cancer Immunotherapy
1996
45
21
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37487665Society for Immunotherapy of Cancer (SITC) checkpoint inhibitor resistance definitions: efforts to harmonize terminology and accelerate immuno-oncology drug development.J Immunother Cancer2023
35074903Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses.J Immunother Cancer2022
35662283Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.Nat Med2022
35362046Hallmarks of Resistance to Immune-Checkpoint Inhibitors.Cancer Immunol Res2022
35449104The "Great Debate" at Immunotherapy Bridge 2021, December 1st-2nd, 2021.J Transl Med2022
36052496Correction: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.Cancer Res2022
36052495Editor's Note: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.Cancer Res2022
33387490CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study.Lancet Oncol2021
34261774Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV<sup>+</sup> Patients.Clin Cancer Res2021
32238470Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce.J Immunother Cancer2020
30755306It Is a Capital Mistake to Theorize Who to Treat with Checkpoint Inhibitors before One Has Data.Trends Cancer2019
31235758HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma.Sci Rep2019
31308059Molecular and Clinical Activity of CDX-3379, an Anti-ErbB3 Monoclonal Antibody, in Head and Neck Squamous Cell Carcinoma Patients.Clin Cancer Res2019
29440171Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer.Cancer Res2018
27815356KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells.Clin Cancer Res2017
28138031Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression.Mol Cancer Ther2017
28723928ErbB activation signatures as potential biomarkers for anti-ErbB3 treatment in HNSCC.PLoS One2017
27986750Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV<sup>+</sup> Patients.Clin Cancer Res2017
27349976Targeting KIT on innate immune cells to enhance the antitumor activity of checkpoint inhibitors.Immunotherapy2016
27279243Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders.Crit Rev Oncog2015
23090886Pharmacokinetic and pharmacodynamic comparability study of moxetumomab pasudotox, an immunotoxin targeting CD22, in cynomolgus monkeys.J Pharm Sci2013
23990866Circulating tumor cells: application as a biomarker for molecular characterization and predictor of survival in an all-comer solid tumor phase I clinical study.PLoS One2013
22327175MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft models.Int J Oncol2012
22070056CD22 as a target for cancer therapy.J Exp Ther Oncol2011
22046260Altered expression of insulin receptor isoforms in breast cancer.PLoS One2011
19782564Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol.Bioorg Med Chem Lett2009
19901556The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression.Cell Cycle2009
19762246Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.Bioorg Med Chem2009
19782568Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs.Bioorg Med Chem Lett2009
18566218Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.Mol Cancer Ther2008
171582052-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice.Endocrinology2007
17910916Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.Bioorg Med Chem2007
17932327Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia.Circ Res2007
17178898Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.Cancer Res2006
16230404beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.Cancer Res2005
125438042-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.Cancer Res2003
127268622ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.Cancer Cell2003
120972762-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.Cancer Res2002
111910572-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate.Cancer Metastasis Rev2000
9712835Synaptotagmin-1 is required for fibroblast growth factor-1 release.J Biol Chem1998
9647656Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration.J Cell Biol1998
9712836S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro.J Biol Chem1998
9712834The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock.J Biol Chem1998
8662999The nuclear trafficking of extracellular fibroblast growth factor (FGF)-1 correlates with the perinuclear association of the FGF receptor-1alpha isoforms but not the FGF receptor-1beta isoforms.J Biol Chem1996
8960122Identification and functional characterization of a highly conserved sequence in the intron of the kappa light chain gene.Mol Immunol1996
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