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Author Details

Gregory A Petsko
Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University
1970
449
89
PMIDPaper TitleJournal TitlePublished Year
36652482Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer.Proc Natl Acad Sci U S A2023
37803174On the causal role of retromer-dependent endosomal recycling in Alzheimer's disease.Nat Cell Biol2023
34937919Identification of RIOK2 as a master regulator of human blood cell development.Nat Immunol2022
35771902Elucidating the causes of neurodegeneration.Science2022
35838234Brain-wide analysis of the supraspinal connectome reveals anatomical correlates to functional recovery after spinal injury.Elife2022
35667922Induced pluripotent stem cells: a tool for modeling Parkinson's disease.Trends Neurosci2022
36180783Structural analysis of human CEACAM1 oligomerization.Commun Biol2022
36174580Before you call the midwife.Cell2022
36344833Chemically stable fluorescent proteins for advanced microscopy.Nat Methods2022
35045281The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease.Cell Rep2022
33332765Targeted stabilization of Munc18-1 function via pharmacological chaperones.EMBO Mol Med2021
33742094Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.Commun Biol2021
34440010A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa.Biology (Basel)2021
34562359A lily worth gilding.Cell2021
34229155A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease.Parkinsonism Relat Disord2021
32451509PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.Nat Chem Biol2020
33268506Endosomal recycling reconciles the Alzheimer's disease paradox.Sci Transl Med2020
33208539mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.Proc Natl Acad Sci U S A2020
3255274125-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner.J Neuroinflammation2020
32402162Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease.N Engl J Med2020
29307487Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.Structure2018
29991141Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms.J Parkinsons Dis2018
29950729Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.Nature2018
30030371Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.J Cell Sci2018
30504845High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.Sci Rep2018
29503090Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.Stem Cell Reports2018
29409358AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.Hum Gene Ther Clin Dev2018
29630349Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.Biochemistry2018
28062648Dual chemistry catalyzed by human acireductone dioxygenase.Protein Eng Des Sel2017
28338942Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily.Protein Eng Des Sel2017
28348215PLP and GABA trigger GabR-mediated transcription regulation in <i>Bacillus subtilis</i> via external aldimine formation.Proc Natl Acad Sci U S A2017
28346784Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).Biochemistry2017
28962801Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.Trends Neurosci2017
26982724Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.Nature2016
27791029Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.Proc Natl Acad Sci U S A2016
27482103Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Proc Natl Acad Sci U S A2016
27482083Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.Proc Natl Acad Sci U S A2016
26858196Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.Biochemistry2016
25354681Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.Gene Ther2015
26056265Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.Proc Natl Acad Sci U S A2015
26050140Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.Lancet Neurol2015
26124091Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.Proc Natl Acad Sci U S A2015
25669742Retromer in Alzheimer disease, Parkinson disease and other neurological disorders.Nat Rev Neurosci2015
25472693The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Neurotherapeutics2015
25363763CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.Nature2015
24351929Structure of a eukaryotic thiaminase I.Proc Natl Acad Sci U S A2014
25378175Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.J Neurosci2014
24747528Pharmacological chaperones stabilize retromer to limit APP processing.Nat Chem Biol2014
24830429Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.PLoS Pathog2014
24882744Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR.Structure2014
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Collaborators

Martin Karplus
Harvard University
Co-authored papers 15
John A Gerlt
University of Illinois at Urbana-Champaign
Co-authored papers 13
Elizabeth A Komives
Co-authored papers 7
Jeffrey N Agar
Northeastern University
Co-authored papers 7
Tom Alber
University of California berkeley
Co-authored papers 7
Diane Joseph-McCarthy
Boston University
Co-authored papers 5
Susan T Lovett
Brandeis University
Co-authored papers 4
John Kuriyan
University of California berkeley
Co-authored papers 4
Karen N Allen
Boston University
Co-authored papers 4
David R Rose
University of Waterloo, University Avenue West
Co-authored papers 4
Constance J Jeffery
University of Illinois at Chicago
Co-authored papers 4
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 4
Stephen K Burley
The State University of New Jersey
Co-authored papers 3
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Albert Einstein College of Medicine
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Icahn School of Medicine at Mount Sinai
Co-authored papers 3
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McLean Hospital and Program in Neuroscience, Harvard Medical School
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Institute of Clinical Molecular Biology, Kiel University
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Mario A Ostrowski
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Max-Planck-Institut fur Entwicklungsbiologie
Co-authored papers 2
John R Yates
TheScripps Research Institute
Co-authored papers 2
Jeha Jeon
Department of Psychiatry and McLean Hospital, Harvard Medical School
Co-authored papers 2
Michael G Rossmann
Purdue University
Co-authored papers 2
Daniel A Bonsor
Co-authored papers 2
Pantelis Tsoulfas
Co-authored papers 2
Michael G Kaplitt
Weill Cornell Medical College
Co-authored papers 2
Susan Lindquist
Whitehead Institute for Biomedical Research
Co-authored papers 2
Thomas Pertel
Co-authored papers 2
Ronald L Klein
Louisiana State University Health Sciences Center
Co-authored papers 2
Eric J Sundberg
Co-authored papers 2
Release 1.2