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Author Details

Amanda K Lukens
Harvard T.H. Chan School of Public Health
2000
42
23
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36927839Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Nat Commun2023
37737220Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.Elife2023
34233174The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.Cell Chem Biol2022
36008486Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.Nat Commun2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34348113Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.Cell Chem Biol2022
34523908Prioritization of Molecular Targets for Antimalarial Drug Discovery.ACS Infect Dis2021
33648890MalDA, Accelerating Malaria Drug Discovery.Trends Parasitol2021
30773881The Adaptive Proline Response in P. falciparum Is Independent of PfeIK1 and eIF2α Signaling.ACS Infect Dis2019
31801884In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.Sci Transl Med2019
29162636Quantitative Proteomic Profiling Reveals Novel <i>Plasmodium falciparum</i> Surface Antigens and Possible Vaccine Candidates.Mol Cell Proteomics2018
30523084Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.Science2018
29336544Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.ACS Infect Dis2018
29326268Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Science2018
27997727Intramolecular Diaza-Diels-Alder Protocol: A New Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks.Chemistry2017
28179098Genome-Wide Association Studies of Drug-Resistance Determinants.Trends Parasitol2017
27412848New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.Sci Rep2016
27933786Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.ACS Infect Dis2016
27602946Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.Nature2016
27538856Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.ChemMedChem2016
27301419A broad analysis of resistance development in the malaria parasite.Nat Commun2016
25336726Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.J Infect Dis2015
26276630Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.Cell2015
26295174Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.Eur J Med Chem2015
25995223The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Sci Transl Med2015
25823686Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.Nat Commun2015
24381157Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.Proc Natl Acad Sci U S A2014
25211597Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.J Med Chem2014
24914738Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.J Med Chem2014
23593309Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.PLoS One2013
24533303Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal.Int J Parasitol Drugs Drug Resist2013
24314037Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal.Malar J2013
22328964Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.ACS Med Chem Lett2012
22688945SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites.Mol Biol Evol2012
22826220Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.Proc Natl Acad Sci U S A2012
22314206Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.Malar J2012
21533027Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.PLoS Genet2011
19077304Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.Genome Biol2008
17159979A genome-wide map of diversity in Plasmodium falciparum.Nat Genet2007
15747257In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins.J Infect Dis2005
12486249Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo.Proc Natl Acad Sci U S A2002
11024163Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation.Nucleic Acids Res2000
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Collaborators

Dyann F Wirth
The Broad Institute
Co-authored papers 38
Elizabeth A Winzeler
University of California San Diego
Co-authored papers 15
Sabine Ottilie
University of California San Diego
Co-authored papers 9
Stephen F Schaffner
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 8
Pardis C Sabeti
Harvard University
Co-authored papers 7
Daniel J Park
Broad Institute of MIT and Harvard
Co-authored papers 6
Madeline R Luth
University of California San Diego
Co-authored papers 6
Stuart L Schreiber
Broad Institute
Co-authored papers 4
Bruce W Birren
Broad Institute of MIT and Harvard
Co-authored papers 4
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 4
Yingyao Zhou
Genomics Institute of the Novartis Research Foundation
Co-authored papers 4
Manu Vanaerschot
Columbia University Irving Medical Center
Co-authored papers 4
Case W McNamara
a division of The Scripps Research Institute La Jolla
Co-authored papers 4
Matthew Abraham
University of California
Co-authored papers 3
Andrea L Cheung
University of California
Co-authored papers 2
Vikas Patil
Princess Margaret Hospital
Co-authored papers 2
Clary B Clish
Broad Institute of MIT and Harvard
Co-authored papers 2
Gregory M Goldgof
University of California san francisco
Co-authored papers 2
Jon Clardy
Harvard Medical School, Blavatnik Institute
Co-authored papers 2
Paul A Clemons
Broad Institute
Co-authored papers 1
Leah E Cowen
University of Toronto
Co-authored papers 1
Jacob D Durrant
University of Pittsburgh
Co-authored papers 1
Hilary K Finucane
Co-authored papers 1
James Bochicchio
Co-authored papers 1
Hong M Moulton
Carlson College of Veterinary Medicine, Oregon State University
Co-authored papers 1
Joseph B McCormick
Co-authored papers 1
Reysha Patel
University of California
Co-authored papers 1
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 1
Robert F Garry
Tulane University School of Medicine
Co-authored papers 1
Adrianne Gladden-Young
Co-authored papers 1
Release 1.2