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Author Details

Gareth R Howell
Tufts University Graduate School of Biomedical Sciences
1997
97
40
PMIDPaper TitleJournal TitlePublished Year
37162819Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease.bioRxiv2023
37546799Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits.bioRxiv2023
37016304Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.BMC Genomics2023
35296661Transcriptional control of retinal ganglion cell death after axonal injury.Cell Death Dis2022
35510549Perspectives on Cognitive Phenotypes and Models of Vascular Disease.Arterioscler Thromb Vasc Biol2022
35370604The <i>APOE</i> <sup>ε3/ε4</sup> Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice.Front Aging Neurosci2022
35429992Vascular derived endothelin receptor A controls endothelin-induced retinal ganglion cell death.Cell Death Discov2022
35461569Improving mouse models for the study of Alzheimer's disease.Curr Top Dev Biol2022
35783454<i>APOE</i> ε4 and exercise interact in a sex-specific manner to modulate dementia risk factors.Alzheimers Dement (N Y)2022
35813947<i>Plcg2<sup>M28L</sup></i> Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.Front Aging Neurosci2022
36016830Pharmacokinetic, pharmacodynamic, and transcriptomic analysis of chronic levetiracetam treatment in 5XFAD mice: A MODEL-AD preclinical testing core study.Alzheimers Dement (N Y)2022
36050860The <i>677Câ¿¿&gt;â¿¿T</i> variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.J Cereb Blood Flow Metab2022
35197847Corrigendum: Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2<sup>*</sup>R47H.Front Aging Neurosci2022
33457489Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.Alzheimers Dement (N Y)2021
33567283Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.Cell Rep2021
33534581Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models.J Proteome Res2021
34707490Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H.Front Aging Neurosci2021
34366832Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.Front Aging Neurosci2021
34254352PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522.EMBO J2021
32273396Deficiency of Complement Component C1Q Prevents Cerebrovascular Damage and White Matter Loss in a Mouse Model of Chronic Obesity.eNeuro2020
31929156Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling.J Alzheimers Dis2020
33172468A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease.Mol Neurodegener2020
33283040Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.Alzheimers Dement (N Y)2020
33176797Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice.J Neuroinflammation2020
32980857Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation.Cell Death Dis2020
32668255Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.Cell Rep2020
30670050Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.Mol Neurodegener2019
31726991Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice.BMC Genomics2019
31878951Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer's disease.Mol Neurodegener2019
31605022Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C.Sci Rep2019
31426806Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity.J Neuroinflammation2019
31369031Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma.Invest Ophthalmol Vis Sci2019
31226014Vascular Inflammation Risk Factors in Retinal Disease.Annu Rev Vis Sci2019
31307838What are the earlier life contributions to reserve and resilience?Neurobiol Aging2019
31150388Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation.PLoS Genet2019
31170535Exercise prevents obesity-induced cognitive decline and white matter damage in mice.Neurobiol Aging2019
29507048A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.Genetics2018
29360998Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.Brain2018
28446616Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.Proc Natl Acad Sci U S A2017
28242160Neuroinflammation in glaucoma: A new opportunity.Exp Eye Res2017
26752265Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.Nat Genet2016
27143421Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease.Neurobiol Aging2016
26888450Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease.Sci Rep2016
26708939Toward more predictive genetic mouse models of Alzheimer's disease.Brain Res Bull2016
27008854C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.Mol Neurodegener2016
27048300Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.Mol Neurodegener2016
25732305TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.J Exp Med2015
26512759APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.PLoS Biol2015
26637126Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.PLoS One2015
26116903Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Exp Eye Res2015
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Collaborators

Gregory W Carter
Tufts University School of Medicine
Co-authored papers 16
Mark T Ross
Illumina Cambridge Ltd.
Co-authored papers 12
David R Bentley
Illumina Cambridge Ltd.
Co-authored papers 8
Lara M Mangravite
Children's Hospital Oakland Research Institute
Co-authored papers 6
Benjamin A Logsdon
Fred Hutchinson Cancer Research Center
Co-authored papers 6
Alison J Coffey
Co-authored papers 6
Pawandeep Dhami
Co-authored papers 5
Nigel P Carter
4Wellcome Trust Sanger Institute
Co-authored papers 5
Christoph Preuss
Universite de Montreal
Co-authored papers 5
Abbot F Clark
North Texas Eye Research Institute, University of North Texas Health Science Center
Co-authored papers 4
Sarah E Hunt
European Bioinformatics Institute
Co-authored papers 4
John C Schimenti
Co-authored papers 4
Louis R Pasquale
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Richard Durbin
University of Cambridge
Co-authored papers 3
Eranga N Vithana
Co-authored papers 3
Catherine M Rice
Co-authored papers 3
Allison E Ashley-Koch
Co-authored papers 3
Laura G Reinholdt
Co-authored papers 3
Robert Ritch
Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai
Co-authored papers 3
Chiea Chuen Khor
Co-authored papers 3
Rhian Gwilliam
The Wellcome Trust Sanger Institute
Co-authored papers 3
David A Mackey
Lions Eye Institute, University of Western Australia
Co-authored papers 3
Alex W Hewitt
Menzies Institute for Medical Research, University of Tasmania
Co-authored papers 3
Ching-Yu Cheng
Singapore Eye Research Institute, Singapore Duke-NUS Medical School
Co-authored papers 3
Tien Yin Wong
Tsinghua University
Co-authored papers 3
Jane Rogers
The Wellcome Trust Sanger Institute
Co-authored papers 3
David M Beare
Co-authored papers 3
Tin Aung
Co-authored papers 3
Jamie E Craig
Flinders Medical Centre, Flinders University
Co-authored papers 3
Chris Clee
Co-authored papers 3
Release 1.2