Author details

Full Name

Timothy E Reddy

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37205457	Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function.		2023
37945901	Transcriptional and epigenetic regulators of human CD8 T cell function identified through orthogonal CRISPR screens.		2023
37831759	Integrin Î±3 promotes T17 cell polarization and extravasation during autoimmune neuroinflammation.		2023
37695916	Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.	Proc Natl Acad Sci U S A	2023
35134344	Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity.	Dev Cell	2022
36243002	ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.	Cell Rep	2022
35609992	Profiling the quantitative occupancy of myriad transcription factors across conditions by modeling chromatin accessibility data.	Genome Res	2022
36423581	Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.	Cell	2022
34049825	Epigenome editing of the CFTR-locus for treatment of cystic fibrosis.	Journal of Cystic Fibrosis	2022
34341582	Transgenic mice for in vivo epigenome editing with CRISPR-based systems.	Nature Methods	2021
34272384	Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.	Nat Commun	2021
34216551	Targeted long-read sequencing identifies missing disease-causing variation.	Am J Hum Genet	2021
33674350	AP-1 subunits converge promiscuously at enhancers to potentiate transcription.	Genome Research	2021
33513136	Causal network inference from gene transcriptional time-series response to glucocorticoids.	PLoS Computational Biology	2021
33722938	Correcting signal biases and detecting regulatory elements in STARR-seq data.	Genome Res	2021
31368479	Bayesian estimation of genetic regulatory effects in high-throughput reporter assays.	Bioinformatics	2020
31570496	c-Maf regulates the plasticity of group 3 innate lymphoid cells by restraining the type 1 program.	Journal of Experimental Medicine	2020
32655414	Functional Genomics of Healthy and Pathological Fetal Membranes.	Frontiers in Physiology	2020
33268355	Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.	Sci Adv	2020
33264623	Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.	Cell Reports	2020
31548729	Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.	Nat Biotechnol	2019
29337990	Clustering gene expression time series data using an infinite Gaussian process mixture model.	PLoS Computational Biology	2018
30097539	Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.	Genome Res	2018
30575722	Human genome-wide measurement of drug-responsive regulatory activity.	Nat Commun	2018
30575519	Genome-wide quantification of the effects of DNA methylation on human gene regulation.	eLife	2018
30087329	Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia.	Nat Commun	2018
30031775	Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids.	Cell Syst	2018
29524151	Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.	Methods Mol Biol	2018
29701825	Predicting gene structure changes resulting from genetic variants via exon definition features.	Bioinformatics	2018
27984826	Decoding the role of regulatory element polymorphisms in complex disease.	Current Opinion in Genetics and Development	2017
28598247	A long-range flexible billboard model of gene activation.	Transcription	2017
28369033	CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome.	Nat Biotechnol	2017
28525990	Transversions have larger regulatory effects than transitions.	BMC Genomics	2017
28317342	Genetic determinants of adiponectin regulation revealed by pregnancy.	Obesity (Silver Spring)	2017
28011790	High-throughput interpretation of gene structure changes in human and nonhuman resequencing data, using ACE.	Bioinformatics	2017
27565349	Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome.	Cell	2016
27459389	HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use.	Endocrinology	2016
27524438	Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.		2016
26025803	Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators.	Genome Res	2015
25494287	Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain.	ACS Synthetic Biology	2015
25492562	Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases.	Molecular Therapy	2015
25692716	Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.	Nature Communications	2015
25614666	New insights into gestational glucose metabolism: lessons learned from 21st century approaches.	Diabetes	2015
25648650	Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.	Nat Commun	2015
25849900	Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.	Nat Biotechnol	2015
26140587	From Prescription to Transcription: Genome Sequence as Drug Target.	Cell	2015
26605881	The PsychENCODE project.	Nat Neurosci	2015
26430153	Genomic approaches for understanding the genetics of complex disease.	Genome Res	2015
26084464	Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.	Genome Res	2015
26501517	Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.	Nat Methods	2015