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Author Details

Philip J R Day
University of Cape Town
1988
138
43
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35350751Cell Surface Transporters and Novel Drug Developments.Front Pharmacol2022
33923485An Analysis of Mechanisms for Cellular Uptake of miRNAs to Enhance Drug Delivery and Efficacy in Cancer Chemoresistance.Noncoding RNA2021
33687205Viral Involvement in Alzheimer's Disease.ACS Chem Neurosci2021
33026554An untargeted metabolomics strategy to measure differences in metabolite uptake and excretion by mammalian cell lines.Metabolomics2020
31132850GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries.ACS Synth Biol2019
31784565The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data.Sci Rep2019
31372510A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.Commun Biol2019
29248726Integrative analysis of rewired central metabolism in temozolomide resistant cells.Biochem Biophys Res Commun2018
29428416GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.Cell Syst2018
27671932SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution.Methods Mol Biol2017
28250099Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA.J R Soc Interface2017
28163087L-β-N-methylamino-l-alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease.Neurotoxicology2017
28396636Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.Front Pharmacol2017
29637127Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.BMJ Paediatr Open2017
29069756Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling.Oncotarget2017
27374766Integrated Electrowetting Nanoinjector for Single Cell Transfection.Sci Rep2016
27933945Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA<sub>2</sub>).J Med Chem2016
27388770Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.Arthritis Res Ther2016
27229172Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB.Sci Rep2016
27167608Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.J Med Chem2016
25503938Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Chem Soc Rev2015
26357572Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.Mol Biol Int2015
26398013The role of microRNAs in the idiopathic inflammatory myopathies.Curr Opin Rheumatol2015
26218264Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.J Med Chem2015
26191369Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.ACS Med Chem Lett2015
24269846Single-cell analysis of K562 cells: an imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and protein.Exp Hematol2014
25589926Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.ACS Med Chem Lett2014
25589925Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.ACS Med Chem Lett2014
25108914SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution.Protein Eng Des Sel2014
24782527GeneGenie: optimized oligomer design for directed evolution.Nucleic Acids Res2014
24734091The IFN-λ Genetic Polymorphism Association With the Viral Clearance Induced by Hepatitis C Virus Treatment in Pakistani Patients.Hepat Mon2014
24896564Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.PLoS One2014
24339206Microfluidic channel-assisted screening of hematopoietic malignancies.Genes Chromosomes Cancer2014
23340812Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.Integr Biol (Camb)2013
24106105HA-coated chitosan nanoparticles for CD44-mediated nucleic acid delivery.Macromol Biosci2013
24103813Hyaluronic acid-coated chitosan nanoparticles: molecular weight-dependent effects on morphology and hyaluronic acid presentation.J Control Release2013
24173381The need for transparency and good practices in the qPCR literature.Nat Methods2013
24260555Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas.PLoS One2013
23615561Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles.Biomaterials2013
23444257Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways.Neuro Oncol2013
23400670Shortened telomere length in patients with systemic lupus erythematosus.Arthritis Rheum2013
21979894Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.J Neurooncol2012
22934066Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism.Front Physiol2012
22779097Perturbation of cell cycle expression in keloid fibroblast.Skinmed2012
22772395Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing.Mol Biosyst2012
22559298Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.BMC Med Genomics2012
22407076Protein profiling of keloidal scar tissue.Arch Dermatol Res2012
20938834Human papilloma virus strain detection utilising custom-designed oligonucleotide microarrays.Methods Mol Biol2011
21943049Dupuytren's: a systems biology disease.Arthritis Res Ther2011
19522540Circulating Lamin B1 (LMNB1) biomarker detects early stages of liver cancer in patients.J Proteome Res2010
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Collaborators

Douglas B Kell
Novo Nordisk Foundation Centre for Biosustainability, Technical University of Denmark
Co-authored papers 16
William E R Ollier
Co-authored papers 7
Neil Swainston
Institute of Systems, University of Liverpool
Co-authored papers 5
Steve O'Hagan
The Manchester Institute of Biotechnology, The University of Manchester
Co-authored papers 5
Marina Wright Muelas
Institute of Systems, University of Liverpool
Co-authored papers 4
David C Wedge
Manchester Cancer Research Centre, University of Manchester
Co-authored papers 4
Xinjian Yan
Co-authored papers 3
Jenny Kan-Suen Pu
Queen Mary Hospital
Co-authored papers 3
Gilberto Ka Kit Leung
The University of Hong Kong
Co-authored papers 3
Panos Deloukas
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 2
Thomas J Hudson
Ontario Institute for Cancer Research
Co-authored papers 2
Steven T Rosen
Co-authored papers 2
Tara C Matise
Co-authored papers 2
Royston Goodacre
Institute of Systems, University of Liverpool
Co-authored papers 2
Bruce W Birren
Broad Institute of MIT and Harvard
Co-authored papers 2
David R Cox
Rinat (Pfizer Inc.)
Co-authored papers 2
Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 2
Richard M Myers
HudsonAlpha Institute for Biotechnology
Co-authored papers 2
Pille Harrison
Co-authored papers 2
Charles Auffray
European Institute for Systems Biology and Medicine
Co-authored papers 2
David R Bentley
Illumina Cambridge Ltd.
Co-authored papers 2
James M Sikela
University of Colorado
Co-authored papers 2
Jacques S Beckmann
University of Lausanne
Co-authored papers 2
Adam Butler
Wellcome Sanger Institute
Co-authored papers 2
Jean Weissenbach
Institut Francois Jacob, CNRS, Universite Paris-Saclay
Co-authored papers 2
Mark S Boguski
Precision Medicine Network Inc.
Co-authored papers 2
Chris Clee
Co-authored papers 2
Heather Gordish-Dressman
Co-authored papers 1
Gregory L Shipley
University of Texas Medical School at Houston
Co-authored papers 1
David C Page
Co-authored papers 1
Release 1.2