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Author Details

Serena Nik-Zainal
Early Cancer Institute, University of Cambridge
1999
109
60
PMIDPaper TitleJournal TitlePublished Year
38036782The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.Nat Genet2024
36797359Correction to: Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts.Br J Cancer2023
37479706Obesity-associated changes in molecular biology of primary breast cancer.Nat Commun2023
37506341Prevalence and significance of DDX41 gene variants in the general population.Blood2023
37316882Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.Breast Cancer Res2023
37116492A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression.Cancer Cell2023
37196218Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays.JCO Precis Oncol2023
36709040Genomic characterisation of hormone receptor-positive breast cancer arising in very young women.Ann Oncol2023
34732853Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts.Br J Cancer2022
35425960Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification.Cancer Res2022
35662281Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests.Oncogene2022
36302863A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.Sci Rep2022
35953586Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells.Nat Genet2022
35949260Substitution mutational signatures in whole-genome-sequenced cancers in the UK population.Science2022
35881546Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer.Clin Cancer Res2022
34228493FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.Mol Cell Biol2021
33670346Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting <i>RB1</i> and Uncovers a Treatment-Related Mutational Signature.Cancers (Basel)2021
34520399Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer.JCI Insight2021
34316057Mutational signatures: emerging concepts, caveats and clinical applications.Nat Rev Cancer2021
32251294Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.Nat Commun2020
35122044Author Correction: A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies.Nat Cancer2020
32059681Mutational signatures: experimental design and analytical framework.Genome Biol2020
31986218Holistic cancer genome profiling for every patient.Swiss Med Wkly2020
33202923Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression.Cancers (Basel)2020
32719340Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.Nat Commun2020
33004253ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer.Ann Oncol2020
32118208A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies.Nat Cancer2020
32471999Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.Nat Commun2020
32332764Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts.Nat Commun2020
30696459From genome integrity to cancer.Genome Med2019
31645345Dramatic response of metastatic cutaneous angiosarcoma to an immune checkpoint inhibitor in a patient with xeroderma pigmentosum: whole-genome sequencing aids treatment decision in end-stage disease.Cold Spring Harb Mol Case Stud2019
31727818Cellular survival over genomic perfection.Science2019
31719696Research culture must be kinder for all, not just royalty.Nature2019
31501597A path inspired by people.Nat Med2019
31346173Author Correction: A practical guide for mutational signature analysis in hematological malignancies.Nat Commun2019
31624251Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.Nat Commun2019
31570896The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.Nat Genet2019
31570822Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study.Nat Med2019
31278357A practical guide for mutational signature analysis in hematological malignancies.Nat Commun2019
30988298Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.Nat Commun2019
30982602A Compendium of Mutational Signatures of Environmental Agents.Cell2019
31090900Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers.Ann Oncol2019
30849372Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.Cell2019
29140415APOBEC3A/B deletion polymorphism and cancer risk.Carcinogenesis2018
30104284Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis.Genome Res2018
30154558The duty to speak up.Nat Cell Biol2018
30252041Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers.Ann Oncol2018
29717121Validating the concept of mutational signatures with isogenic cell models.Nat Commun2018
29323295Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.Nature2018
28904067Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency.Cancer Res2017
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Collaborators

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Wellcome Sanger Institute
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Clinical Research Facility, Mercy University Hospital
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Sunil R Lakhani
University of Queensland
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Jonathan Hinton
Inivata Ltd
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Gilles Thomas
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Gunes Gundem
Memorial Sloan Kettering Cancer Center
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Susanna L Cooke
Institute of Cancer Sciences, University of Glasgow
Co-authored papers 11
Lucy A Stebbings
Wellcome Trust Sanger Institute
Co-authored papers 11
Inigo Martincorena
Wellcome Sanger Institute
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Ultan McDermott
Wellcome Sanger Institute
Co-authored papers 10
Paul N Span
Radboud University Medical Center
Co-authored papers 10
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 9
Release 1.2