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Author Details

Charles M Rudin
Memorial Sloan Kettering Cancer Center
1989
364
106
PMIDPaper TitleJournal TitlePublished Year
37931288Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma.Cancer Discov2024
37838086Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 Inactivation.J Thorac Oncol2024
37976444SKYSCRAPER-02: Tiragolumab in Combination With Atezolizumab Plus Chemotherapy in Untreated Extensive-Stage Small-Cell Lung Cancer.J Clin Oncol2024
36240971Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228.J Thorac Oncol2023
37808711Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma.bioRxiv2023
37487667Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study.J Immunother Cancer2023
37555284Phase I Study of Entinostat, Atezolizumab, Carboplatin, and Etoposide in Previously Untreated Extensive-Stage Small Cell Lung Cancer, ETCTN 10399.Oncologist2023
37589215Outcomes of Combination Platinum-Doublet Chemotherapy and Anti-PD(L)-1 Blockade in KRASG12C-Mutant Non-Small Cell Lung Cancer.Oncologist2023
37795442ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy.Front Oncol2023
37502974Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth.bioRxiv2023
37531417Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.Sci Transl Med2023
37425844Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in <i>KEAP1</i> mutant lung cancer.bioRxiv2023
36993643Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF).bioRxiv2023
36951942IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models.J Clin Invest2023
37084736Genomic mapping of metastatic organotropism in lung adenocarcinoma.Cancer Cell2023
37182602Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification.J Thorac Oncol2023
37382635De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways.Clin Cancer Res2023
37210008Clinical Benefit From Immunotherapy in Patients With SCLC Is Associated With Tumor Capacity for Antigen Presentation.J Thorac Oncol2023
37001526Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade.Cancer Cell2023
37231281Breathing room - focusing on the 'other' lung cancer.Nat Cancer2023
37131623<i>In vivo</i> metabolomics identifies CD38 as an emergent vulnerability in <i>LKB1</i> -mutant lung cancer.bioRxiv2023
37098228Tarlatamab: New Star on the Horizon for Small-Cell Lung Cancer?J Clin Oncol2023
37432985Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer.Clin Cancer Res2023
37355629Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer.J Hematol Oncol2023
37127830Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies.Nat Immunol2023
36889516Randomized Phase 2 Placebo-Controlled Trial of Nintedanib for the Treatment of Radiation Pneumonitis.Int J Radiat Oncol Biol Phys2023
36871392Safety and clinical activity of atezolizumab plus erlotinib in patients with non-small-cell lung cancer.ESMO Open2023
36574773The ectonucleotidase CD39 identifies tumor-reactive CD8<sup>+</sup> T cells predictive of immune checkpoint blockade efficacy in human lung cancer.Immunity2023
36824957CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion.bioRxiv2023
36669791Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in patients with advanced solid tumors.J Immunother Cancer2023
36494075Molecular Biomarkers of Disease Outcomes and Mechanisms of Acquired Resistance to First-Line Osimertinib in Advanced EGFR-Mutant Lung Cancers.J Thorac Oncol2023
36307533Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies.Nat Rev Clin Oncol2023
34561242<i>Smarca4</i> Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung.Cancer Discov2022
35584676WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC.Cell Rep2022
35477182Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer.Cancer Epidemiol Biomarkers Prev2022
35613997Rationale and Design of the Phase 3 KEYLYNK-013 Study of Pembrolizumab With Concurrent Chemoradiotherapy Followed by Pembrolizumab With or Without Olaparib for Limited-Stage Small-Cell Lung Cancer.Clin Lung Cancer2022
35613620ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.Mol Cell2022
35440124Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts.Nat Commun2022
35767426Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer.Clin Cancer Res2022
35704797Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.JCO Precis Oncol2022
35792876Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset.Clin Cancer Res2022
35760287POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC.J Thorac Oncol2022
35789380PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry.Cancer Discov2022
35759660Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer.Proc Natl Acad Sci U S A2022
35691495Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistance in SCLC.J Thorac Oncol2022
35361996Inferring gene expression from cell-free DNA fragmentation profiles.Nat Biotechnol2022
35941262cfDNA methylome profiling for detection and subtyping of small cell lung cancers.Nat Cancer2022
36313536Protocol to dissociate, process, and analyze the human lung tissue using single-cell RNA-seq.STAR Protoc2022
36275912BMS-986012, an Anti-Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study.JTO Clin Res Rep2022
36357680Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer.Nat Med2022
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Collaborators

Laura and Isaac Perlmutter Cancer Center
Co-authored papers 70
Memorial Sloan Kettering Cancer Center
Co-authored papers 48
Memorial Sloan Kettering Cancer Center
Co-authored papers 47
Co-authored papers 33
Memorial Sloan Kettering Cancer Center
Co-authored papers 30
Druckenmiler Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center
Co-authored papers 23
Co-authored papers 21
Co-authored papers 17
Co-authored papers 12
University of Texas Southwestern Medical Center at Dallas
Co-authored papers 10
Memorial Sloan Kettering Cancer Center
Co-authored papers 10
Memorial Sloan Kettering Cancer Center
Co-authored papers 10
Siteman Cancer Center, Washington University School of Medicine
Co-authored papers 9
Memorial Sloan-Kettering Cancer Center
Co-authored papers 8
Department of Pediatrics Stanford University Stanford California USA.
Co-authored papers 8
Memorial Sloan Kettering Cancer Center
Co-authored papers 8
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
Co-authored papers 7
Memorial Sloan Kettering Cancer Center
Co-authored papers 7
Co-authored papers 7
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 7
The University of Texas MD Anderson Cancer Center
Co-authored papers 6
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Co-authored papers 6
University of Maryland School of Medicine
Co-authored papers 6
Meyer Cancer Center
Co-authored papers 6
University of Chicago
Co-authored papers 6
Memorial Sloan Kettering Cancer Center
Co-authored papers 5
Massachusetts General Hospital Cancer Center, Harvard Medical School
Co-authored papers 5
Washington University School of Medicine
Co-authored papers 5
Co-authored papers 5
Memorial Sloan Kettering Cancer Center
Co-authored papers 4