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Author Details

Alexander Kohlmann
Oncology R&D
2002
136
52
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35091440Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib).Clin Cancer Res2022
34135391A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce.Sci Rep2021
29759569Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology.Crit Rev Oncol Hematol2018
29728319Current status and trends in the diagnostics of AML and MDS.Blood Rev2018
28557976Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.Br J Cancer2017
28222336A two-step approach for sequencing spliceosome-related genes as a complementary diagnostic assay in MDS patients with ringed sideroblasts.Leuk Res2017
28399885Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia.J Hematol Oncol2017
28472036Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients.PLoS One2017
28492898Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS-Mutant Advanced Non-Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial.JAMA2017
29045535SELECT-2: a phase II, double-blind, randomized, placebo-controlled study to assess the efficacy of selumetinib plus docetaxel as a second-line treatment of patients with advanced or metastatic non-small-cell lung cancer.Ann Oncol2017
29018576Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice.ESMO Open2017
28751759A comparative study of germline BRCA1 and BRCA2 mutation screening methods in use in 20 European clinical diagnostic laboratories.Br J Cancer2017
26220041Next-generation deep-sequencing detects multiple clones of CALR mutations in patients with BCR-ABL1 negative MPN.Leukemia2016
27741277Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes.PLoS One2016
27168466The role of the RAS pathway in iAMP21-ALL.Leukemia2016
26992948Mutations of TP53 gene in adult acute lymphoblastic leukemia at diagnosis do not affect the achievement of hematologic response but correlate with early relapse and very poor survival.Haematologica2016
26867670Clinical impact of low-burden BCR-ABL1 mutations detectable by amplicon deep sequencing in Philadelphia-positive acute lymphoblastic leukemia patients.Leukemia2016
26918901Optimised Pre-Analytical Methods Improve KRAS Mutation Detection in Circulating Tumour DNA (ctDNA) from Patients with Non-Small Cell Lung Cancer (NSCLC).PLoS One2016
25367136Next-generation deep sequencing improves detection of BCR-ABL1 kinase domain mutations emerging under tyrosine kinase inhibitor treatment of chronic myeloid leukemia patients in chronic phase.J Cancer Res Clin Oncol2015
26630574A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia.PLoS One2015
25659728Mutational profiling in patients with MDS: ready for every-day use in the clinic?Best Pract Res Clin Haematol2015
25527566Refractory anemia with ring sideroblasts and marked thrombocytosis cases harbor mutations in SF3B1 or other spliceosome genes accompanied by JAK2V617F and ASXL1 mutations.Haematologica2015
25586593Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.Nat Commun2015
23958918Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease.Leukemia2014
25212276Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status.Leukemia2014
24829203TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis.Blood2014
24925730A robust molecular pattern for myelodysplastic syndromes in two independent cohorts investigated by next-generation sequencing can be revealed by comparative bioinformatic analyses.Br J Haematol2014
24619868Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.Genes Chromosomes Cancer2014
24523240Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis.Blood2014
24693539TET2 overexpression in chronic lymphocytic leukemia is unrelated to the presence of TET2 variations.Biomed Res Int2014
24704494Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.Cell Stem Cell2014
24363398Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.Blood2014
24493299Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome.Genes Chromosomes Cancer2014
24413067BAALC expression: a suitable marker for prognostic risk stratification and detection of residual disease in cytogenetically normal acute myeloid leukemia.Blood Cancer J2014
24497565Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases.Haematologica2014
24113472SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients.Leukemia2014
24056881The role of different genetic subtypes of CEBPA mutated AML.Leukemia2014
24220272Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.Leukemia2014
24144312Perspective on how to approach molecular diagnostics in acute myeloid leukemia and myelodysplastic syndromes in the era of next-generation sequencing.Leuk Lymphoma2014
24164563Postallogeneic monitoring with molecular markers detected by pretransplant next-generation or Sanger sequencing predicts clinical relapse in patients with myelodysplastic/myeloproliferative neoplasms.Eur J Haematol2014
22814295GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis.Leukemia2013
24052547EZH2 mutations are frequent and represent an early event in follicular lymphoma.Blood2013
23860447Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients.Leukemia2013
23958953Comprehensive mutational profiling in advanced systemic mastocytosis.Blood2013
23680131Robustness of amplicon deep sequencing underlines its utility in clinical applications.J Mol Diagn2013
23648669Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics.Leukemia2013
23794064Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain.Blood2013
23383300Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.PLoS One2013
23535558High incidence of RAS signalling pathway mutations in MLL-rearranged acute myeloid leukemia.Leukemia2013
23521373CEBPA double-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases with TET2 and GATA2 alterations impacting prognosis.Br J Haematol2013
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Collaborators

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Columbia University Irving Medical Center
Co-authored papers 15
Kyoto University
Co-authored papers 5
Universitatsklinikum Jena
Co-authored papers 4
Sapienza University.
Co-authored papers 4
University of California San Diego
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University of California San Diego
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Dana-Farber Cancer Institute
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Harvard Stem Cell Institute, Harvard Medical School
Co-authored papers 2
Tokyo Medical and Dental University
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TriLink BioTechnologies LLC.
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Center for Genomic Medicine, Rigshospitalet Copenhagen University Hospital
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Hannover Medical School
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Hannover Medical School
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Institute for Biomedical Research August Pi I Sunyer
Co-authored papers 1
Rigshospitalet, University of Copenhagen
Co-authored papers 1
Moores Cancer Center, University of California San Diego
Co-authored papers 1
Radboud university medical center
Co-authored papers 1
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University of Montreal Health Center
Co-authored papers 1
German Cancer Research Center (DKFZ)
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University of California San Diego
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Meyer Cancer Center
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Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL)
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Northwestern University
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The Institute for Cancer Research
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National Cancer Institute, National Institutes of Health
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