Skip to Main Content

Author Details

Luke Whitesell
University of Toronto
1979
135
58
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37369212Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.Cell Chem Biol2023
37500616Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.Nat Commun2023
37607350Potent Antifungal Activity of Penta-<i>O</i>-galloyl-β-d-Glucose against Drug-Resistant <i>Candida albicans</i>, <i>Candida auris</i>, and Other Non-<i>albicans Candida</i> Species.ACS Infect Dis2023
34525326Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.Structure2022
35584803Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens.ACS Chem Biol2022
35752611Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.Nat Commun2022
36300931The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis.mBio2022
36294667Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens.J Fungi (Basel)2022
35149760Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.Commun Biol2022
34849848Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence.Genetics2022
35294249HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state.Sci Adv2022
33444025Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.J Med Chem2021
33484500Fluorescence Polarization-Based Measurement of Protein-Ligand Interaction in Fungal Cell Lysates.Curr Protoc2021
34433036The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans.Cell Rep2021
34686660A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.Nat Commun2021
34127794Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.Leukemia2021
33964438Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides.Bioorg Med Chem Lett2021
31513387Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors.J Med Chem2020
31924499Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.Cell Chem Biol2020
32015439HSF1 phase transition mediates stress adaptation and cell fate decisions.Nat Cell Biol2020
33353950An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.Nat Commun2020
32661007Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability.Antimicrob Agents Chemother2020
32573189Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens.ACS Chem Biol2020
32179530Enhanced Efflux Pump Expression in <i>Candida</i> Mutants Results in Decreased Manogepix Susceptibility.Antimicrob Agents Chemother2020
32269162Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <i>Candida</i> Species.mSphere2020
32156828Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris.mBio2020
30679438Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.Nat Commun2019
31213460Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.Clin Cancer Res2019
31164776Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
31133756Mitochondrial metabolism promotes adaptation to proteotoxic stress.Nat Chem Biol2019
29227471Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy.Nat Chem Biol2018
29392504Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.Cell Stress Chaperones2018
29537263Withaferin A and Withanolide D Analogues with Dual Heat-Shock-Inducing and Cytotoxic Activities: Semisynthesis and Biological Evaluation.J Nat Prod2018
28028240Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.Proc Natl Acad Sci U S A2017
28215707HSP90 Shapes the Consequences of Human Genetic Variation.Cell2017
28490664Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.Sci Transl Med2017
29229832FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proc Natl Acad Sci U S A2017
26916008Preface.Adv Cancer Res2016
27884995Susan Lindquist (1949-2016).Science2016
27524297A Fungal-Selective Cytochrome bc<sub>1</sub> Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol2016
27338157Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.Chemistry2016
25514979Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products.J Am Chem Soc2015
26122846Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.Cancer Res2015
25910212Widespread macromolecular interaction perturbations in human genetic disorders.Cell2015
26030729Nontoxic antimicrobials that evade drug resistance.Nat Chem Biol2015
24625088Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.J Med Chem2014
25489079HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.Proc Natl Acad Sci U S A2014
25122673Calcineurin determines toxic versus beneficial responses to α-synuclein.Proc Natl Acad Sci U S A2014
25083868The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.Cell2014
23811600Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.Nat Biotechnol2013
  • 1 - 50 of 135

Recommended Authors

Hao Shao
Department of Pharmaceutical Chemistry, University of California San Francisco
Career Start Year 2015
Number of shared co-authors 0
Reza Beheshti Zavareh
The Scripps Research Institute
Career Start Year 2008
Number of shared co-authors 0
Luke L Lairson
The Scripps Research Institute
Career Start Year 2003
Number of shared co-authors 2
Barak Rotblat
Ben-Gurion University of the Negev
Career Start Year 2002
Number of shared co-authors 0
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Career Start Year 2000
Number of shared co-authors 3
Chandra C Ghosh
The Wistar Institute
Career Start Year 1999
Number of shared co-authors 0
Rose Hurren
Princess Margaret Cancer Centre
Career Start Year 1999
Number of shared co-authors 1
Krishna P Bhat
Department of Neurosurgery at the University of Texas MD Anderson Cancer Center
Career Start Year 1998
Number of shared co-authors 0
Laura B Corson
Broad Institute of MIT and Harvard
Career Start Year 1998
Number of shared co-authors 0
Jack Taunton
University of California san francisco
Career Start Year 1996
Number of shared co-authors 5
Ranjini K Sundaram
Yale University
Career Start Year 1996
Number of shared co-authors 0
Theresa M LaVallee
Parker Institute for Cancer Immunotherapy
Career Start Year 1996
Number of shared co-authors 0
Aykut Uren
Georgetown University Medical Center
Career Start Year 1991
Number of shared co-authors 0
Alessandro Datti
University of Perugia
Career Start Year 1991
Number of shared co-authors 3
Ricky W Johnstone
The University of Melbourne
Career Start Year 1990
Number of shared co-authors 1
Timothy A Lewis
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Career Start Year 1990
Number of shared co-authors 9
Aaron D Schimmer
Princess Margaret Cancer Centre
Career Start Year 1989
Number of shared co-authors 1
Kevan M Shokat
University of California San Francisco
Career Start Year 1987
Number of shared co-authors 5
Charles L Sawyers
Memorial Sloan Kettering Cancer Center
Career Start Year 1986
Number of shared co-authors 5
Marcela Gronda
Princess Margaret Cancer Centre
Career Start Year 1985
Number of shared co-authors 1
Alexander Kamb
Inc. 30301 Agoura Rd.
Career Start Year 1979
Number of shared co-authors 3
Fabien Calvo
Universite de Paris-Cite
Career Start Year 1979
Number of shared co-authors 0
Robert H Shoemaker
National Cancer Institute
Career Start Year 1978
Number of shared co-authors 0
Scott H Kaufmann
Mayo Clinic
Career Start Year 1977
Number of shared co-authors 1
Anne Monks
Institute of Biomedical Engineering (IBME), University of Oxford
Career Start Year 1976
Number of shared co-authors 0
Frank McCormick
Frederick National Laboratory for Cancer Research
Career Start Year 1975
Number of shared co-authors 2
Paul Workman
The Institute of Cancer Research
Career Start Year 1974
Number of shared co-authors 3
Peter J Houghton
The University of Texas Health Science Center at San Antonio
Career Start Year 1971
Number of shared co-authors 2
Garth Powis
PHusis Therapeutics Inc.
Career Start Year 1970
Number of shared co-authors 0
John N Weinstein
The University of Texas MD Anderson Cancer Center
Career Start Year 1968
Number of shared co-authors 4

Collaborators

Susan Lindquist
Whitehead Institute for Biomedical Research
Co-authored papers 34
Leah E Cowen
University of Toronto
Co-authored papers 25
Sandro Santagata
Co-authored papers 17
Rochelle Bagatell
Co-authored papers 10
Nancy U Lin
Co-authored papers 5
Catherine A McLellan
Whitehead Institute
Co-authored papers 5
Alex K Lancaster
Ronin Institute
Co-authored papers 4
Joshua A Bittker
Co-authored papers 3
Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 3
Stuart L Schreiber
Broad Institute
Co-authored papers 3
Giorgio Gaglia
Co-authored papers 2
Marc Vidal
Blavatnik Institute, Harvard Medical School
Co-authored papers 2
Aviad Tsherniak
Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard
Co-authored papers 2
Nathanael S Gray
Harvard Medical School
Co-authored papers 2
John L Markley
University of Wisconsin-Madison
Co-authored papers 2
Rong Hu
Co-authored papers 2
Guillaume Kugener
Keck School of Medicine of the University of California los angeles
Co-authored papers 2
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Song Yi
Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin
Co-authored papers 2
Charles Boone
University of Toronto
Co-authored papers 2
Nidhi Sahni
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Alexei Savchenko
University of Toronto
Co-authored papers 2
Paola Picotti
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 2
Yu Xia
College of Information Engineering, Zhejiang University of Technology
Co-authored papers 1
Andrea L Cheung
University of California
Co-authored papers 1
Jennifer Yang
Chang Gung Memorial Hospital
Co-authored papers 1
Jacob D Durrant
University of Pittsburgh
Co-authored papers 1
Tyler Jacks
Co-authored papers 1
Jon Clardy
Harvard Medical School, Blavatnik Institute
Co-authored papers 1
Clarence Yapp
Co-authored papers 1
Release 1.2