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Author Details

Adam L Orr
Appel Alzheimer's Disease Research Institute
2008
31
23
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37075107Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.Sci Adv2023
37904938Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.bioRxiv2023
37019383Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.Mol Cell Proteomics2023
31627168The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production.Redox Biol2020
30883359Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.J Alzheimers Dis2019
31667474To be or not to be pink(1): contradictory findings in an animal model for Parkinson's disease.Brain Commun2019
29851006Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.Methods Mol Biol2018
28434973Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Neurochem Int2017
28462393Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.eNeuro2017
27667666Suppressors of Superoxide-H<sub>2</sub>O<sub>2</sub> Production at Site I<sub>Q</sub> of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.Cell Metab2016
26368590Suppressors of superoxide production from mitochondrial complex III.Nat Chem Biol2015
24587137Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.PLoS One2014
24746616Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.Free Radic Biol Med2014
23583329Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.Free Radic Biol Med2013
24024165Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.Redox Biol2013
23994103Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.Free Radic Biol Med2013
23669642NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.Neurosci Lett2013
23786614The role of mitochondrial function and cellular bioenergetics in ageing and disease.Br J Dermatol2013
22634524Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.Neurosci Lett2012
22940066Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.Free Radic Biol Med2012
23124204A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.J Biol Chem2012
22689576Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.J Biol Chem2012
22507528Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.J Neuroinflammation2012
21242311A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.J Cell Sci2011
19591925Impaired mitochondrial trafficking in Huntington's disease.Biochim Biophys Acta2010
19525944Adenosine A(2A) receptor mediates microglial process retraction.Nat Neurosci2009
18362179Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.J Cell Biol2008
18337408N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.J Neurosci2008
18400759Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.J Biol Chem2008
18620047A FRET-based method to study protein thiol oxidation in histological preparations.Free Radic Biol Med2008
18558632Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.Hum Mol Genet2008
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Collaborators

Allan I Levey
Emory University School of Medicine
Co-authored papers 3
James J Lah
Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine
Co-authored papers 3
Victoria J Dardov
Co-authored papers 2
Billy W Newton
University of California San Francisco
Co-authored papers 2
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 2
David Jimenez-Morales
J. David Gladstone Institutes
Co-authored papers 2
Robert W Mahley
Gladstone Institute of Neurological Disease
Co-authored papers 2
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Chaeyoung Kim
Seoul National University, College of Medicine
Co-authored papers 1
Andrzej Swistowski
Buck Institute for Age Research
Co-authored papers 1
Michael R Hayden
Co-authored papers 1
Simon Melov
Buck Institute for Research on Aging
Co-authored papers 1
Benjamin J Polacco
Co-authored papers 1
Zeynep Cakir
Ataturk University
Co-authored papers 1
R Dyche Mullins
University of California San Francisco, USA Howard Hughes Medical Institute
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Xianmin Zeng
College of Food Science and Technology, Nanjing Agricultural University
Co-authored papers 1
Eric J Huang
University of California san francisco
Co-authored papers 1
Alexandre da Cruz
Co-authored papers 1
Gwendolyn M Jang
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Co-authored papers 1
Samuel J Lord
University of California San Francisco, USA Howard Hughes Medical Institute
Co-authored papers 1
Manon Eckhardt
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Release 1.2