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Author Details

John G Kuhn
1980
173
54
PMIDPaper TitleJournal TitlePublished Year
37335291Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer.Oncotarget2023
35852795Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.Clin Cancer Res2022
35610507Targeting aberrant replication and DNA repair events for treating breast cancers.Commun Biol2022
34910551A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer.Sci Transl Med2021
33235994Phase I/II study of sorafenib in combination with erlotinib for recurrent glioblastoma as part of a 3-arm sequential accrual clinical trial: NABTC 05-02.Neurooncol Adv2020
30993905Metformin modifies disparity in hepatocellular carcinoma incidence in men with type 2 diabetes but without chronic liver diseases.Cancer Med2019
31477168A randomized, controlled phase II trial of neoadjuvant ado-trastuzumab emtansine, lapatinib, and nab-paclitaxel versus trastuzumab, pertuzumab, and paclitaxel in HER2-positive breast cancer (TEAL study).Breast Cancer Res2019
30861105A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium.Int J Cancer2019
29783757A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier.Pharmaceutics2018
28988377Phase I study of sorafenib and tipifarnib for recurrent glioblastoma: NABTC 05-02.J Neurooncol2018
29941486Phase I and Biomarker Study of Plerixafor and Bevacizumab in Recurrent High-Grade Glioma.Clin Cancer Res2018
29485888Personalized Medicine in Nasal Delivery: The Use of Patient-Specific Administration Parameters To Improve Nasal Drug Targeting Using 3D-Printed Nasal Replica Casts.Molecular Pharmaceutics2018
29301832Pharmacological Inhibition of NOS Activates ASK1/JNK Pathway Augmenting Docetaxel-Mediated Apoptosis in Triple-Negative Breast Cancer.Clin Cancer Res2018
29608984Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells.Cancer Lett2018
29475723Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.Lancet Oncol2018
29074604Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma.Clin Cancer Res2018
27542768Safety and Pharmacodynamics of the PDE4 Inhibitor Roflumilast in Advanced B-cell Malignancies.Clinical Cancer Research2017
28220479A phase 1/2 trial of ublituximab, a novel anti-CD20 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukaemia previously exposed to rituximab.Br J Haematol2017
28112516Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.Journal of Natural Products2017
27026681Metformin for Reducing Racial/Ethnic Difference in Prostate Cancer Incidence for Men with Type II Diabetes.Cancer Prev Res (Phila)2016
26341136Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure-activity relationship and unique pyrrolylation of primary amines.Bioorganic and Medicinal Chemistry Letters2015
25934816Toward precision medicine in glioblastoma: the promise and the challenges.Neuro Oncol2015
23525756A first-in-human dose-escalation study of ME-143, a second generation NADH oxidase inhibitor, in patients with advanced solid tumors.Invest New Drugs2014
25395315Pharmacogenomic diversity of tamoxifen metabolites and estrogen receptor genes in Hispanics and non-Hispanic whites with breast cancer.Breast Cancer Res Treat2014
24470557Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02.Neuro Oncol2014
21739168Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery.J Neurooncol2012
22588883Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.Cancer Discov2012
22923449Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03.Clin Cancer Res2012
23099651Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02.Neuro Oncol2012
21813511Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?Neuro Oncol2011
21377994A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03.Neuro Oncol2011
20150371A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas.Neuro Oncol2010
20150372A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy.Neuro Oncol2010
18795290Phase I and pharmacokinetic study of mitomycin C and celecoxib as potential modulators of tumor resistance to irinotecan in patients with solid malignancies.Cancer Chemotherapy and Pharmacology2009
20009104EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.Sci Signal2009
18838439Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies.Oncologist2008
17610262A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a Children's Oncology Group study.Pediatric Blood and Cancer2008
17694310Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study.Cancer Chemother Pharmacol2008
18559968Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium.Neuro Oncol2008
18082778Does intraosseous equal intravenous? A pharmacokinetic study.American Journal of Emergency Medicine2008
18356283Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas.Neuro Oncol2008
18094423Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma.Clin Cancer Res2007
18056194Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study.Clin Cancer Res2007
16685529Thalidomide and celecoxib as potential modulators of irinotecan's activity in cancer patients.Cancer Chemotherapy and Pharmacology2007
16877733Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.J Clin Oncol2006
16317728Phase I trial of irofulven (MGI 114) in pediatric patients with solid tumors.Pediatric Blood and Cancer2006
16317586Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy.Breast Cancer Res Treat2006
16622259Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients.Journal of Clinical Oncology2006
16533878A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study.Neuro Oncol2006
16778106Phase 1 and pharmacokinetic study of intravenous irinotecan in refractory solid tumor patients with hepatic dysfunction.Clinical Cancer Research2006
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Ohio State University
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