Skip to Main Content

Author Details

Richard B Lock
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
1987
218
57
PMIDPaper TitleJournal TitlePublished Year
36380143Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.Leukemia2023
37523146High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.Cancer Res2023
37679323PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia.Blood Cancer J2023
36989489STAT5 activation promotes progression and chemotherapy resistance in early T-cell precursor acute lymphoblastic leukemia.Blood2023
36976863Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.Sci Signal2023
37339930In vivo activity of the dual SYK/FLT3 inhibitor TAK-659 against pediatric acute lymphoblastic leukemia xenografts.Pediatr Blood Cancer2023
37140091In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts.Pediatr Blood Cancer2023
37267628The tip of the iceberg-The roles of long noncoding RNAs in acute myeloid leukemia.Wiley Interdiscip Rev RNA2023
37196067Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.Sci Transl Med2023
34417224PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by <i>NSD2</i> Mutation in Pediatric Acute Lymphoblastic Leukemia.Cancer Discov2022
35677155The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression.Front Oncol2022
35651714The Promise of Single-cell Technology in Providing New Insights Into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia.Hemasphere2022
35647029Circulating Tumor DNA in Pediatric Cancer.Front Mol Biosci2022
35223487Exploring the Metabolic Landscape of AML: From Haematopoietic Stem Cells to Myeloblasts and Leukaemic Stem Cells.Front Oncol2022
33067575Quantitative phosphoproteomics uncovers synergy between DNA-PK and FLT3 inhibitors in acute myeloid leukaemia.Leukemia2021
33830207The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL.Blood Adv2021
33895784Combination efficacy of ruxolitinib with standard-of-care drugs in CRLF2-rearranged Ph-like acute lymphoblastic leukemia.Leukemia2021
33837299Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin.Br J Cancer2021
33608527Author Correction: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.Nat Commun2021
33555272RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.J Clin Invest2021
34481852A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia.Int J Biol Macromol2021
34683974Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia.Pharmaceutics2021
34230493Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.Nat Commun2021
31325323Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia.Int J Cancer2020
31876116Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia.Pediatr Blood Cancer2020
31896781OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis.Leukemia2020
31971998Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia.Blood Adv2020
31848452Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia.Leukemia2020
33277497Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.Nat Commun2020
32801162Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in <i>CRLF2</i>-Rearranged Ph-like ALL.Mol Cancer Res2020
32753387PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.Mol Cancer Ther2020
32242100Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression.Br J Cancer2020
32266130Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer.Front Oncol2020
32536690Examining treatment responses of diagnostic marrow in murine xenografts to predict relapse in children with acute lymphoblastic leukaemia.Br J Cancer2020
30514801T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development.Haematologica2019
31693904Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.Cell Rep2019
31853178Thiol-Reactive Star Polymers Functionalized with Short Ethoxy-Containing Moieties Exhibit Enhanced Uptake in Acute Lymphoblastic Leukemia Cells.Int J Nanomedicine2019
31821784A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.Cancer Cell2019
31015346OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.Clin Cancer Res2019
30777875A Phase II Study of Alisertib in Children with Recurrent/Refractory Solid Tumors or Leukemia: Children's Oncology Group Phase I and Pilot Consortium (ADVL0921).Clin Cancer Res2019
31012549Preclinical activity of the antibody-drug conjugate denintuzumab mafodotin (SGN-CD19A) against pediatric acute lymphoblastic leukemia xenografts.Pediatr Blood Cancer2019
30679330Romidepsin enhances the efficacy of cytarabine <i>in vivo</i>, revealing histone deacetylase inhibition as a promising therapeutic strategy for <i>KMT2A</i>-rearranged infant acute lymphoblastic leukemia.Haematologica2019
29531323Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression.Br J Cancer2018
30093523Protocol for the avatar acceptability study: a multiperspective cross-sectional study evaluating the acceptability of using patient-derived xenografts to guide personalised cancer care in Australia and New Zealand.BMJ Open2018
30537513Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia.Cancer Cell2018
30385234The Avatar Acceptability Study: Survivor, Parent and Community Willingness to Use Patient-Derived Xenografts to Personalize Cancer Care.EBioMedicine2018
27650817Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.Pediatr Blood Cancer2017
28119366Bioluminescence Imaging Enhances Analysis of Drug Responses in a Patient-Derived Xenograft Model of Pediatric ALL.Clin Cancer Res2017
27786412Initial testing of VS-4718, a novel inhibitor of focal adhesion kinase (FAK), against pediatric tumor models by the Pediatric Preclinical Testing Program.Pediatr Blood Cancer2017
27055868MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.Leukemia2016
  • 1 - 50 of 218

Recommended Authors

Thai Hoa Tran
Universite de Montreal
Career Start Year 2013
Number of shared co-authors 5
Amanda L Christie
Dana-Farber Cancer Institute
Career Start Year 2010
Number of shared co-authors 5
Anagha Deshpande
Sanford Burnham Prebys Medical Discovery Institute
Career Start Year 2009
Number of shared co-authors 1
Kara L Davis
Stanford University School of Medicine
Career Start Year 2008
Number of shared co-authors 4
Amanda Winters
University of Colorado School of Medicine
Career Start Year 2008
Number of shared co-authors 1
Anupriya Agarwal
Knight Cancer Institute, Oregon Health & Science University
Career Start Year 2006
Number of shared co-authors 3
Yana Pikman
Dana Farber Cancer Institute
Career Start Year 2005
Number of shared co-authors 5
Tara L Lin
University of Kansas Medical Center
Career Start Year 2004
Number of shared co-authors 2
Ronan Swords
Oregon Health and Science University
Career Start Year 2004
Number of shared co-authors 2
Anna M Eiring
Texas Tech University Health Sciences Center at El Paso
Career Start Year 2004
Number of shared co-authors 2
Giovanni Roti
University of Parma
Career Start Year 2003
Number of shared co-authors 4
Christopher C Porter
Emory University School of Medicine
Career Start Year 2003
Number of shared co-authors 5
Jeffrey W Tyner
Oregon Health & Science University School of Medicine
Career Start Year 2002
Number of shared co-authors 13
Phillip M Clair
Huntsman Cancer Institute, The University of Utah
Career Start Year 2001
Number of shared co-authors 0
Rose Hurren
Princess Margaret Cancer Centre
Career Start Year 1999
Number of shared co-authors 2
Timothy S Pardee
Comprehensive Cancer Center of Wake Forest Baptist Health, Medical Center Boulevard
Career Start Year 1995
Number of shared co-authors 1
Kimberly Stegmaier
Dana-Farber Cancer Institute
Career Start Year 1995
Number of shared co-authors 19
Yongjin Li
Mayo Clinic
Career Start Year 1995
Number of shared co-authors 16
Meenakshi Devidas
St Jude Children's Research Hospital
Career Start Year 1993
Number of shared co-authors 18
Olaf Witt
Hopp Children's Cancer Center Heidelberg (KiTZ)
Career Start Year 1993
Number of shared co-authors 8
Bill H Chang
Oregon Health and Science University
Career Start Year 1993
Number of shared co-authors 8
Aaron D Schimmer
Princess Margaret Cancer Centre
Career Start Year 1989
Number of shared co-authors 4
Daniel J DeAngelo
Dana-Farber Cancer Institute
Career Start Year 1989
Number of shared co-authors 7
Sima Jeha
St. Jude Children's Research Hospital
Career Start Year 1988
Number of shared co-authors 11
David M Loeb
Children's Hospital at Montefiore.
Career Start Year 1986
Number of shared co-authors 5
Marcela Gronda
Princess Margaret Cancer Centre
Career Start Year 1985
Number of shared co-authors 2
Ching-Hon Pui
St. Jude Children's Research Hospital
Career Start Year 1980
Number of shared co-authors 14
Gregory H Reaman
National Cancer Institute
Career Start Year 1978
Number of shared co-authors 16
Scott H Kaufmann
Mayo Clinic
Career Start Year 1977
Number of shared co-authors 2
Alex Look
Dana-Farber Cancer Institute
Career Start Year 1975
Number of shared co-authors 21

Collaborators

Malcolm A Smith
National Cancer Institute
Co-authored papers 78
Peter J Houghton
The University of Texas Health Science Center at San Antonio
Co-authored papers 74
Charles Patrick Reynolds
Cancer Center, Texas Tech University Health Sciences Center
Co-authored papers 61
John M Maris
Children's Hospital of Philadelphia
Co-authored papers 58
Richard Gorlick
University of Texas MD Anderson Cancer Center
Co-authored papers 56
Stephen T Keir
Co-authored papers 55
Edward A Kolb
Co-authored papers 55
Christopher L Morton
St. Jude Children's Research Hospital.
Co-authored papers 40
Raushan T Kurmasheva
The University of Texas Health Science Center at San Antonio
Co-authored papers 31
Kathryn Evans
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 27
Glenn M Marshall
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 23
Michelle Haber
School of Clinical Medicine
Co-authored papers 20
Chelsea Mayoh
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 13
Hannah McCalmont
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 10
Michelle J Henderson
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 7
Charles G Mullighan
St Jude Children's Research Hospital
Co-authored papers 6
Ricky W Johnstone
The University of Melbourne
Co-authored papers 6
Paul G Ekert
Co-authored papers 5
Mignon L Loh
University of Washington
Co-authored papers 4
Katerina Bendak
Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine
Co-authored papers 4
Berthold Göttgens
Co-authored papers 4
Geoffrey Neale
St. Jude Children's Research Hospital
Co-authored papers 4
Veronique Litalien
Walter and Eliza Hall Institute of Medical Research
Co-authored papers 3
Javed Khan
Center for Cancer Research, National Cancer Institute
Co-authored papers 3
Stephen P Hunger
Children's Hospital of Philadelphia
Co-authored papers 3
Matthew D Dun
Co-authored papers 3
Hagop Kantarjian
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
Mark J Cowley
Children's Cancer Institute, Lowy Cancer Research Centre
Co-authored papers 3
Mark J Raftery
Co-authored papers 3
Dias Kurmashev
Greehey Children's Cancer Research Institute
Co-authored papers 3
Release 1.2