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Author Details

William McCoull
Oncology R&D
1999
29
16
PMIDPaper TitleJournal TitlePublished Year
34973110Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment.Arch Toxicol2022
35533086Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems.Mol Pharm2022
34195728Diversity-orientated synthesis of macrocyclic heterocycles using a double S<sub>N</sub>Ar approach.Org Biomol Chem2021
33683117Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.J Med Chem2021
33646774Correction to "Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles".J Med Chem2021
33495510Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy.Commun Biol2021
34478292Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy.J Med Chem2021
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
33119085A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.Biochem J2020
31361481Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.J Med Chem2019
30335946Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.ACS Chem Biol2018
28714680Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.J Med Chem2017
28485934Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.J Med Chem2017
28374589Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.J Med Chem2017
29206860The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1.PLoS One2017
27994749Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.ACS Med Chem Lett2016
25050640Synthesis of 3-(hetero)aryl tetrahydropyrazolo[3,4-c]pyridines by Suzuki-Miyaura cross-coupling methodology.J Org Chem2014
24967667Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.J Med Chem2014
23541044Experimental testing of quantum mechanical predictions of mutagenicity: aminopyrazoles.Chem Res Toxicol2013
22608962Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.Bioorg Med Chem Lett2012
22691057Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).J Med Chem2012
19854647Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.Bioorg Med Chem Lett2009
157154908-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.J Med Chem2005
12636410Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of alpha-amino phosphonates.J Org Chem2003
118436152H-Azirine 3-phosphonates: a new class of chiral iminodienophiles. Asymmetric synthesis of quaternary piperidine phosphonates.Org Lett2002
12529988Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells.Anticancer Res2002
11334560Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen.J Med Chem2001
10825956Asymmetric synthesis of alpha-methylphosphophenylalanine derivatives using sulfinimine-derived enantiopure aziridine-2-phosphonates.Org Lett1999
11674458Concise Asymmetric Synthesis of alpha-Amino Acid Derivatives from N-Sulfinylimino Esters.J Org Chem1999
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Collaborators

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Repare Therapeutics Inc.
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Oncology R&D
Co-authored papers 2
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Oncology R&D
Co-authored papers 2
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Co-authored papers 2
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 1
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Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Wellcome Sanger Institute
Co-authored papers 1
H3 Biomedicine Inc.
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The University of Melbourne
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Dana-Farber Cancer Institute
Co-authored papers 1