Author details

Full Name

Shaun R Coughlin

Affiliation

ORCID

Career Start Year

1980

Papers

183

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34995278	Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models.	PLoS One	2022
33318667	Microglial G<sub>i</sub>-dependent dynamics regulate brain network hyperexcitability.	Nat Neurosci	2021
33617510	Thoracic Surgeon Impressions of the Impact of the COVID-19 Pandemic on Lung Cancer Care-Lessons from the First Wave in Canada.	Current Oncology	2021
32903402	Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis.	Frontiers in Immunology	2020
30821975	Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals.	J Am Chem Soc	2019
29411438	A rapid fluorogenic GPCR-Î²-arrestin interaction assay.	Protein Science	2018
29974860	A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.	Developmental Cell	2018
30102523	Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule.	Biochemistry	2018
29351851	Visualizing Dynamics of Cell Signaling InÂ Vivo with a Phase Separation-Based Kinase Reporter.	Molecular Cell	2018
29307513	Visualizing Dynamics of Cell Signaling InÂ Vivo with a Phase Separation-Based Kinase Reporter.	Molecular Cell	2018
29301867	Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia.	Journal of Cell Biology	2018
29339534	Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.	Sci Signal	2018
29336885	Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.	Structure	2018
28267013	Systemic Metronidazole May Not Reduce Posthemorrhoidectomy Pain: A Meta-Analysis of Randomized Controlled Trials.	Dis Colon Rectum	2017
28329764	The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.	Nature	2017
27582371	Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.	Circulation Research	2016
27066836	A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.	Nature Communications	2016
27333774	Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development.	Developmental Biology	2016
27447051	Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis InÂ Vivo.	Cell Chemical Biology	2016
27559095	Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis.	Science Translational Medicine	2016
26574834	Is it safe to wait? The effect of surgical wait time on survival in patients with non-small cell lung cancer.	Canadian Journal of Surgery	2015
25742284	Mechanical vessel injury in zebrafish embryos.	Journal of Visualized Experiments	2015
25695968	GÎ±i/o-coupled receptor signaling restricts pancreatic Î²-cell expansion.	Proc Natl Acad Sci U S A	2015
25866997	Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart.	Journal of Visualized Experiments	2015
26228483	Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.	Blood	2015
26561004	Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM.	Nature Communications	2015
26473617	An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish.	Elife	2015
26167642	Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape.	Nature Methods	2015
26423607	Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.	Nat Commun	2015
25988291	Preoperative chemotherapy for resectable thoracic esophageal cancer.		2015
25180532	The imperative to invest in science has never been greater.	J Clin Invest	2014
25278288	Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice.	Arteriosclerosis, Thrombosis, and Vascular Biology	2014
25293779	Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race.	Blood	2014
23202729	PAR1 contributes to influenza A virus pathogenicity in mice.	Journal of Clinical Investigation	2013
23995678	Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2.	Nature	2013
23883509	High-concentration oxygen and surgical site infections in abdominal surgery: a meta-analysis.	Canadian Journal of Surgery	2013
23657000	IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.	International Immunology	2013
23222541	High-resolution crystal structure of human protease-activated receptor 1.	Nature	2012
22854148	Management of chest tubes after pulmonary resection: a systematic review and meta-analysis.	Canadian Journal of Surgery	2012
22419412	Somatostatin analogues for the treatment of enterocutaneous fistulas: a systematic review and meta-analysis.	World Journal of Surgery	2012
23021219	TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.	Cell	2012
22106277	Wnt/Î²-catenin signaling is differentially regulated by GÎ± proteins and contributes to fibrous dysplasia.	Proc Natl Acad Sci U S A	2011
21245842	PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.	Nature Communications	2011
21960637	GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.	Science	2011
21642988	The sphingosine 1-phosphate receptor S1Pâ¿¿ maintains the homeostasis of germinal center B cells and promotes niche confinement.	Nat Immunol	2011
21860019	Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.	Blood	2011
20490560	Better late than never? Impact of local analgesia timing on postoperative pain in laparoscopic surgery: a systematic review and metaanalysis.	Surgical Endoscopy and Other Interventional Techniques	2010
20930120	Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.	Proceedings of the National Academy of Sciences of the United States of America	2010
20351302	Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group.	Circulation	2010
20026661	Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.	J Exp Med	2010