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Author Details

Avner Schlessinger
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
2003
104
40
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36865220Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue.bioRxiv2023
37679563Substrate binding and inhibition of the anion exchanger 1 transporter.Nat Struct Mol Biol2023
38037155Genome-wide prediction of pathogenic gain- and loss-of-function variants from ensemble learning of a diverse feature set.Genome Med2023
37693436Exploring the Druggable Conformational Space of Protein Kinases Using AI-Generated Structures.bioRxiv2023
36865220Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue.bioRxiv2023
36856089Conserved allosteric inhibition mechanism in SLC1 transporters.Elife2023
37355450Targeting SLC transporters: small molecules as modulators and therapeutic opportunities.Trends Biochem Sci2023
36914446Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients.Trends Pharmacol Sci2023
37693436Exploring the Druggable Conformational Space of Protein Kinases Using AI-Generated Structures.bioRxiv2023
37679563Substrate binding and inhibition of the anion exchanger 1 transporter.Nat Struct Mol Biol2023
38037155Genome-wide prediction of pathogenic gain- and loss-of-function variants from ensemble learning of a diverse feature set.Genome Med2023
37355450Targeting SLC transporters: small molecules as modulators and therapeutic opportunities.Trends Biochem Sci2023
36856089Conserved allosteric inhibition mechanism in SLC1 transporters.Elife2023
36914446Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients.Trends Pharmacol Sci2023
36343260Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.Proc Natl Acad Sci U S A2022
36369754Describing inhibitor specificity for the amino acid transporter LAT1 from metainference simulations.Biophys J2022
35443909Exploring the conformational diversity of proteins.Elife2022
35881481Structural signatures: a web server for exploring a database of and generating protein structural features from human cell lines and tissues.Database (Oxford)2022
36343260Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.Proc Natl Acad Sci U S A2022
36568026Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters.J Phys Org Chem2022
35443909Exploring the conformational diversity of proteins.Elife2022
36568026Alanine serine cysteine transporter (ASCT) substrate binding site properties probed with hydroxyhomoserine esters.J Phys Org Chem2022
36369754Describing inhibitor specificity for the amino acid transporter LAT1 from metainference simulations.Biophys J2022
35881481Structural signatures: a web server for exploring a database of and generating protein structural features from human cell lines and tissues.Database (Oxford)2022
32828650SLC16 Family: From Atomic Structure to Human Disease.Trends Biochem Sci2021
33999203PredictProtein - Predicting Protein Structure and Function for 29 Years.Nucleic Acids Res2021
33568516Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies.Sci Transl Med2021
33568355Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling.Cancer Discov2021
33941686Protein structure-based gene expression signatures.Proc Natl Acad Sci U S A2021
33766168Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study.Psychol Med2021
33440120Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.Biochemistry2021
34083538Crowdsourced mapping of unexplored target space of kinase inhibitors.Nat Commun2021
33295676Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions.Med Res Rev2021
33230949The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake.ChemMedChem2021
32828650SLC16 Family: From Atomic Structure to Human Disease.Trends Biochem Sci2021
34520464Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.PLoS Comput Biol2021
34507995Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.Proc Natl Acad Sci U S A2021
34447313An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.Front Pharmacol2021
34762822Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.Am J Hum Genet2021
33766168Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study.Psychol Med2021
33568516Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies.Sci Transl Med2021
33568355Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling.Cancer Discov2021
34762822Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.Am J Hum Genet2021
34520464Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.PLoS Comput Biol2021
34507995Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.Proc Natl Acad Sci U S A2021
34447313An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.Front Pharmacol2021
33941686Protein structure-based gene expression signatures.Proc Natl Acad Sci U S A2021
34083538Crowdsourced mapping of unexplored target space of kinase inhibitors.Nat Commun2021
33999203PredictProtein - Predicting Protein Structure and Function for 29 Years.Nucleic Acids Res2021
33295676Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions.Med Res Rev2021
  • 1 - 50 of 208

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Collaborators

Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 19
Peter Man-Un Ung
Co-authored papers 18
Kathleen M Giacomini
University of California San Francisco
Co-authored papers 16
Burkhard Rost
Technical University of Munich (TUM)
Co-authored papers 16
Massimiliano Bonomi
Institut Pasteur, Universite Paris Cite, CNRS UMR 8
Co-authored papers 7
Marco Punta
Co-authored papers 5
Huan-Chieh Chien
University of California San Francisco
Co-authored papers 5
Robert M Stroud
University of California San Francisco
Co-authored papers 5
Hao Fan
College of Biotechnology and Bioengineering, Zhejiang University of Technology
Co-authored papers 4
Ursula Pieper
University of California san francisco
Co-authored papers 4
Thomas E Ferrin
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 4
Ross L Cagan
University of Glasgow
Co-authored papers 4
Sook Wah Yee
University of California San Francisco
Co-authored papers 4
Ligong Chen
Tsinghua University
Co-authored papers 3
Justin Guinney
University of Washington
Co-authored papers 3
L??szl?? Kaj??n
TUM (Technische Universitat Munchen)
Co-authored papers 3
Abraham Reichenberg
Co-authored papers 3
Ravi Iyengar
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Eric A Sobie
Co-authored papers 3
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Kristen K Dang
Benaroya Research Institute at Virginia Mason
Co-authored papers 3
Arvin C Dar
Co-authored papers 3
Arik A Zur
Schools of Pharmacy and Medicine, University of California san francisco
Co-authored papers 3
Joseph D Buxbaum
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Lakshmi A Devi
Co-authored papers 2
Chris Sander
Broad Institute of MIT and Harvard
Co-authored papers 2
Zygy Roe-Zurz
Pfizer Inc.
Co-authored papers 2
Susan J Johns
Center for Visualization, Washington State University
Co-authored papers 2
Reinhard Schneider
Co-authored papers 2
Robert J Allaway
Geisel School of Medicine, Dartmouth College
Co-authored papers 2
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