Author details

Full Name

John Kuriyan

Affiliation

University of California berkeley

ORCID

Career Start Year

1982

Papers

229

H Index

Expertise

CM4AI Collaborator

Andrej Sali (CM4AI)

PMID	Paper Title	Journal Title	Published Year
37310965	Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.	PLoS One	2023
35272765	A saturation-mutagenesis analysis of the interplay between stability and activation in Ras.	Elife	2022
35507881	A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.	Proc Natl Acad Sci U S A	2022
36173161	Saturation mutagenesis of a predicted ancestral Syk-family kinase.	Protein Sci	2022
35982670	Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.	bioRxiv	2022
36122200	Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.	Proc Natl Acad Sci U S A	2022
34330837	GHB analogs confer neuroprotection through specific interaction with the CaMKIIÎ± hub domain.	Proc Natl Acad Sci U S A	2021
33847559	Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction.	Elife	2021
34601763	Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.	Protein Sci	2021
34454301	New insights into Raf regulation from structural analyses.	Curr Opin Struct Biol	2021
34846302	A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.	Elife	2021
34562363	Structural basis and regulation of the reductive stress response.	Cell	2021
34740968	Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS.	Proc Natl Acad Sci U S A	2021
32519675	CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks.	Elife	2020
31653643	Structural Insights into the Regulation of Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II (CaMKII).	Cold Spring Harb Perspect Biol	2020
32902386	Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.	Elife	2020
32814905	Structural basis for dimerization quality control.	Nature	2020
32149607	Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.	Elife	2020
29610148	The Interdependent Activation of Son-of-Sevenless and Ras.	Cold Spring Harb Perspect Med	2019
31611699	Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.	Nat Immunol	2019
31604311	Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.	Science	2019
30926793	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.	Nat Commun	2019
30942928	Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca<sup>2+</sup> /calmodulin-dependent protein kinase II.	Protein Sci	2019
30846600	A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.	Science	2019
31076553	Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.	Proc Natl Acad Sci U S A	2019
30598552	Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation.	Nat Struct Mol Biol	2019
29547119	Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.	Elife	2018
29915297	Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.	Nat Immunol	2018
30183386	The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases.	Crit Rev Biochem Mol Biol	2018
30012625	Deep mutational analysis reveals functional trade-offs in the sequences of EGFR autophosphorylation sites.	Proc Natl Acad Sci U S A	2018
29498112	Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.	Protein Sci	2018
27932698	Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.	SLAS Discov	2017
28952923	A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.	Elife	2017
28923919	Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.	Proc Natl Acad Sci U S A	2017
28686159	Deconstruction of the Ras switching cycle through saturation mutagenesis.	Elife	2017
28735895	A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.	Mol Cell	2017
26783323	A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.	J Exp Med	2016
27700984	An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.	Elife	2016
27370798	Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.	Proc Natl Acad Sci U S A	2016
27017828	Molecular basis for multimerization in the activation of the epidermal growth factor receptor.	Elife	2016
26828794	Crystal Structure of a Ube2S-Ubiquitin Conjugate.	PLoS One	2016
26949248	Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.	Elife	2016
25287889	Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.	Biochem J	2015
26124280	Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.	Mol Cell Biol	2015
25837374	Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).	PLoS One	2015
25990959	The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.	Sci Signal	2015
25621509	A structural perspective on the regulation of the epidermal growth factor receptor.	Annu Rev Biochem	2015
25699547	Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.	Elife	2015
25779001	Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.	Biochem J	2015
24473075	Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.	Elife	2014

1 - 50 of 229

Marc C Deller

Incyte Corporation

Career Start Year 2000

Number of shared co-authors 0

Andrew P VanDemark

University of Pittsburgh

Career Start Year 2000

Number of shared co-authors 0

Sergey M Vorobiev

Columbia University

Career Start Year 1998

Number of shared co-authors 1

Clemens Vonrhein

Global Phasing Ltd

Career Start Year 1995

Number of shared co-authors 1

Diana R Tomchick

University of Texas Southwestern Medical Center

Career Start Year 1993

Number of shared co-authors 3

John E Ladbury

University of Leeds

Career Start Year 1992

Number of shared co-authors 0

Gye Won Han

Bridge Institute, University of Southern California

Career Start Year 1991

Number of shared co-authors 1

Milton H Werner

Inhibikase Therapeutics Inc.

Career Start Year 1991

Number of shared co-authors 3

Vadim A Klenchin

University of Wisconsin-Madison

Career Start Year 1991

Number of shared co-authors 1

Natarajan Kannan

University of Georgia

Career Start Year 1990

Number of shared co-authors 4

Michael K Rosen

UT Southwestern Medical Center

Career Start Year 1990

Number of shared co-authors 6

P??r Nordlund

Karolinska Institutet, BioClinicum J6

Career Start Year 1989

Number of shared co-authors 2

Sirano Dhe-Paganon

Dana-Farber Cancer Institute

Career Start Year 1989

Number of shared co-authors 4

Maria Sunnerhagen

Linkoping University

Career Start Year 1989

Number of shared co-authors 0

Cheryl H Arrowsmith

University of Toronto

Career Start Year 1989

Number of shared co-authors 4

Steven C Almo

Albert Einstein College of Medicine

Career Start Year 1988

Number of shared co-authors 6

Liang Tong

Columbia University

Career Start Year 1988

Number of shared co-authors 6

Miriam Eisenstein

Weizmann Institute of Science

Career Start Year 1988

Number of shared co-authors 2

Aled M Edwards

University of Toronto

Career Start Year 1984

Number of shared co-authors 3

Opher Gileadi

Structural Genomics Consortium Karolinska Institute Stockholm Sweden.

Career Start Year 1984

Number of shared co-authors 3

Lawrence Shapiro

Zuckerman Mind Brain Behaviour Institute

Career Start Year 1982

Number of shared co-authors 4

Walter J Chazin

and Center for Structural Biology, Vanderbilt University

Career Start Year 1982

Number of shared co-authors 4

Ruth Nussinov

Sackler School of Medicine, Tel Aviv University

Career Start Year 1980

Number of shared co-authors 2

David A Agard

University of California, USA Quantitative Biosciences Institute (QBI) san francisco

Career Start Year 1977

Number of shared co-authors 7

Tom Alber

University of California berkeley

Career Start Year 1976

Number of shared co-authors 4

George N Phillips

Rice University

Career Start Year 1974

Number of shared co-authors 3

Tom L Blundell

Heartand Lung Research Institute, University of Cambridge

Career Start Year 1971

Number of shared co-authors 2

Robert J Fletterick

University of California San Francisco

Career Start Year 1971

Number of shared co-authors 4

Sung-Hou Kim

University of California berkeley

Career Start Year 1967

Number of shared co-authors 4

Robert M Stroud

University of California San Francisco

Career Start Year 1965

Number of shared co-authors 7

row(s) 1 - 30 of 30

Mike O'Donnell

The Rockefeller University

Co-authored papers 36

Arthur Weiss

University of California san francisco

Co-authored papers 15

Martin Karplus

Harvard University

Co-authored papers 11

David Cowburn

Albert Einstein College of Medicine

Co-authored papers 6

Angus C Nairn

Co-authored papers 6

David E Shaw

Columbia University

Co-authored papers 6

Michael Rape

Howard Hughes Medical Institute, University of California at Berkeley

Co-authored papers 6

Neil P Shah

University of California San Francisco

Co-authored papers 5

Philip A Cole

Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School

Co-authored papers 5

Natalia Jura

Cardiovascular Research Institute, University of California San Francisco

Co-authored papers 5

Oliver Hantschel

Institute of Physiological Chemistry, University of Marburg 35032 Marburg Germany .

Co-authored papers 5

Brian D Guenther

University of Michigan ann arbor

Co-authored papers 4

Tanja Kortemme

University of California san francisco

Co-authored papers 4

Gregory A Petsko

Helen and Robert Appel Alzheimer's Disease Research Institute, Cornell University

Co-authored papers 4

Andrej Sali (CM4AI)

University of California San Francisco

Co-authored papers 3

Evan R Williams

University of California berkeley

Co-authored papers 3

Oren S Rosenberg

University of California san francisco

Co-authored papers 3

Rene Onrust

University of California san francisco

Co-authored papers 3

Brian T Chait

The Rockefeller University

Co-authored papers 3

Pradeep Bandaru

Howard Hughes Medical Institute, University of California berkeley

Co-authored papers 3

Charles L Sawyers

Memorial Sloan Kettering Cancer Center

Co-authored papers 2

Rashna Bhandari

Co-authored papers 2

Wayne A Hendrickson

Columbia University

Co-authored papers 2

Catherine C Smith

University of California San Francisco

Co-authored papers 2

Gregory D Friedland

Joint BioEnergy Institute

Co-authored papers 2

Rama Ranganathan

Co-authored papers 2

Alexander R Pico

Institute of Data Science and Biotechnology, Gladstone Institutes

Co-authored papers 2

Jie J Zheng

Molecular Biology Institute, University of California los angeles

Co-authored papers 2

Hidesaburo Hanafusa

Rockefeller University

Co-authored papers 2

Stephen K Burley

The State University of New Jersey

Co-authored papers 2

1 - 30

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