Author details

Full Name

Christina S Leslie

Affiliation

ORCID

Career Start Year

2002

Papers

135

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37419111	Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.	Mol Cell	2023
37280678	Epiphany: predicting Hi-C contact maps from 1D epigenomic signals.		2023
37277655	Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis.		2023
37085479	RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.	Nat Commun	2023
36711541	3D Chromatin Dynamics during Innate and Adaptive Immune Memory Acquisition.		2023
37398096	Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.		2023
36877162	Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell Resolution.	Cancer Res	2023
36810256	SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis.	JCI Insight	2023
36745870	Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering.	Blood	2023
37546906	ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.		2023
34937932	Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.	Nature Immunology	2022
35396274	Chromatin interaction-aware gene regulatory modeling with graph attention networks.	Genome Research	2022
35394814	Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity.	Science immunology	2022
35971180	BindVAE: Dirichlet variational autoencoders for de novo motif discovery from accessible chromatin.	Genome Biol	2022
35705800	Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.	Nat Immunol	2022
36167829	TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.	Nature Communications	2022
35444279	Programme of self-reactive innate-like T cell-mediated cancer immunity.	Nature	2022
35442400	The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation.	Cancer Res	2022
36070798	Novel antigen-presenting cell imparts T<sub>reg</sub>-dependent tolerance to gut microbiota.	Nature	2022
35618834	Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.	Nat Immunol	2022
35787684	CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.	Nat Cell Biol	2022
35247584	Globin vector regulatory elements are active in early hematopoietic progenitor cells.	Molecular Therapy	2022
35149530	Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation.	J Immunol	2022
35165384	Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.	Nat Biotechnol	2022
35115713	SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.	Nat Cancer	2022
34535775	Artificial intelligence in cancer research, diagnosis and therapy.	Nat Rev Cancer	2021
33861994	Single-cell sequencing links multiregional immune landscapes and tissue-resident TÂ cells in ccRCC to tumor topology and therapy efficacy.	Cancer Cell	2021
33891860	A unified atlas of CD8 TÂ cell dysfunctional states in cancer and infection.	Mol Cell	2021
33571445	Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets.		2021
34099725	HiC-DC+ enables systematic 3D interaction calls and differential analysis for Hi-C and HiChIP.	Nat Commun	2021
34031415	Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility.	Nat Commun	2021
33979589	Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses.	Immunity	2021
33817986	KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.	Mol Oncol	2021
34458856	Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.	Nat Cancer	2021
32497496	High-Resolution InÂ Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down.	Molecular Cell	2020
31932695	ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer.	Nat Genet	2020
32332729	HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.	Nature Communications	2020
32492433	Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.	Cell Reports	2020
33318189	FXR mediates T cell-intrinsic responses to reduced feeding during infection.	Proceedings of the National Academy of Sciences of the United States of America	2020
33176163	The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries.	Immunity	2020
32895534	Author Correction: FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.	Nature	2020
31243370	FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes.	Nature	2019
31668803	Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.	Cell	2019
31554806	Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers.	Nat Commun	2019
30472158	IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.	Cell Stem Cell	2019
30643266	Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function.	Nature Immunology	2019
31291575	FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation.	Cell Reports	2019
31027997	Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8Â T Cells.	Immunity	2019
31406384	BindSpace decodes transcription factor binding signals by large-scale sequence embedding.	Nature Methods	2019
31263280	Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12.	Nat Immunol	2019