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Author Details

Adrian P Bracken
Smurfit Institute of Genetics, Trinity College Dublin
1999
55
31
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37030288PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1.Mol Cell2023
35312747Analytical Validation of a Novel 6-Gene Signature for Prediction of Distant Recurrence in Estrogen Receptor-Positive, HER2-Negative, Early-Stage Breast Cancer.Clin Chem2022
36173104Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.Elife2022
35013241Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7.Nat Commun2022
33232890Structural basis for PRC2 engagement with chromatin.Curr Opin Struct Biol2021
33503407The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.Mol Cell2021
34294917Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.Nat Genet2021
34090143Prognostic value of the 6-gene OncoMasTR test in hormone receptor-positive HER2-negative early-stage breast cancer: Comparative analysis with standard clinicopathological factors.Eur J Cancer2021
31862236Anticancer innovative therapy: Highlights from the ninth annual meeting.Cytokine Growth Factor Rev2020
33855271The future of genomics in Ireland - focus on genomics for health.HRB Open Res2020
32084351If You Like It Then You Shoulda Put Two "RINGs" on It: Delineating the Roles of vPRC1 and cPRC1.Mol Cell2020
30885427The 3D Genome: EZH2 Comes into the Fold.Trends Mol Med2019
31521505PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.Mol Cell2019
31575610PRC2 functions in development and congenital disorders.Development2019
31123059Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer.Genes Dev2019
29628311A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.Mol Cell2018
29606589The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells.Mol Cell2018
28554894Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.EMBO J2017
28381411Dual functionality of <i>cis</i>-regulatory elements as developmental enhancers and Polycomb response elements.Genes Dev2017
27634302Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.Mol Cell Proteomics2016
26652297The PCL1-p53 axis promotes cellular quiescence.Cell Cycle2016
25736863Phenotypic analysis of familial breast cancer: comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.Eur J Surg Oncol2015
26438725MED23: a new Mediator of H2B monoubiquitylation.EMBO J2015
26250988Protein-truncating variants in moderate-risk breast cancer susceptibility genes: a meta-analysis of high-risk case-control screening studies.Cancer Genet2015
26497635PRC2 mediated H3K27 methylations in cellular identity and cancer.Curr Opin Cell Biol2015
26494712A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.Genes Dev2015
26687479The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.Sci Rep2015
26094870Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.FEBS J2015
26094658Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.FEBS J2015
26223664Native gel analysis of macromolecular protein complexes in cultured mammalian cells.Proteomics2015
25032261Stem cell epigenetics: looking forward.Cell Stem Cell2014
23395440A "complex" issue: deciphering the role of variant PRC1 in ESCs.Cell Stem Cell2013
23948251CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.Dev Cell2013
23690441Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.J Exp Med2013
23160351Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.Nat Struct Mol Biol2012
21383691Transcriptional regulation of cellular senescence.Oncogene2011
19682593Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation.Semin Cell Dev Biol2009
19851313Polycomb group proteins: navigators of lineage pathways led astray in cancer.Nat Rev Cancer2009
18977325H3K79 methylation profiles define murine and human MLL-AF4 leukemias.Cancer Cell2008
18931660A model for transmission of the H3K27me3 epigenetic mark.Nat Cell Biol2008
19022750Regulation of stem cell differentiation by histone methyltransferases and demethylases.Cold Spring Harb Symp Quant Biol2008
17332741Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.EMBO J2007
17912037E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells.Cell Cycle2007
17344414The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.Genes Dev2007
17339329The polycomb group protein Suz12 is required for embryonic stem cell differentiation.Mol Cell Biol2007
16618801Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.Genes Dev2006
16179649Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.Nucleic Acids Res2005
14752272Polycomb group proteins in cell cycle progression and cancer.Cell Cycle2004
15362224E2F target genes: unraveling the biology.Trends Biochem Sci2004
15385962Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.EMBO J2004
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Collaborators

Kristian Helin
The Institute of Cancer Research
Co-authored papers 17
Diego Pasini
European Institute of Oncology IRCCS
Co-authored papers 12
Gundula Streubel
Smurfit Institute of Genetics, Trinity College Dublin
Co-authored papers 9
Gerard Cagney
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 7
Kieran Wynne
University College Dublin
Co-authored papers 6
Eric Conway
Conway Institute, University College Dublin
Co-authored papers 5
Giorgio Oliviero
University College Dublin
Co-authored papers 5
Eleanor Glancy
Smurfit Institute of Genetics, Trinity College Dublin
Co-authored papers 5
Darren J Fitzpatrick
Smurfit Institute of Genetics, Trinity College Dublin
Co-authored papers 5
Haruhiko Koseki
RIKEN Research Center for Allergy and Immunology
Co-authored papers 4
Ariane Watson
University College Dublin
Co-authored papers 4
Karsten Hokamp
Smurfit Institute of Genetics, Trinity College of Dublin
Co-authored papers 3
William M Gallagher
All-Island Cancer Research Institute, UCD Conway Institute, University College Dublin
Co-authored papers 3
Eugene T Dillon
Conway Institute of Biomolecular and Biomedical Research
Co-authored papers 2
Karin Jirstr??m
Lund University
Co-authored papers 2
Sriganesh Jammula
Early Cancer Institute, Hutchison Research Centre, University of Cambridge
Co-authored papers 2
Scott A Armstrong
Boston Children's Hospital
Co-authored papers 2
Catherine Egan
Moorfields Eye Hospital NHS Foundation Trust
Co-authored papers 2
Gian Luca Negri
British Columbia Cancer Research Institute
Co-authored papers 2
Darran P O'Connor
UCD Conway Institute, University College Dublin
Co-authored papers 2
Andrea Scelfo
Institut Curie, PSL Research University, CNRS
Co-authored papers 2
Juri Rappsilber
Institute for Biotechnology, Technical University Berlin
Co-authored papers 2
Aoife McLysaght
Smurfit Institute of Genetics, Trinity College Dublin
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Catherine M Kelly
Mater Misericordiae University Hospital
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Maike Sander
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Release 1.2