Author details

Full Name

Richard H Karas

Affiliation

ORCID

Career Start Year

1987

Papers

209

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37891053	Delaying reperfusion plus left ventricular unloading reduces infarct size: Sub-analysis of DTU-STEMI pilot study.		2023
35000420	Intermittent Occlusion of the Superior Vena Cava to Improve Hemodynamics in Patients With Acutely Decompensated Heart Failure: The VENUS-HF Early Feasibility Study.	Circulation: Heart Failure	2022
33782857	Myocardial Injury Promotes Matrix Metalloproteinase-9 Activity in the Renal Cortex in Preclinical Models of Acute Myocardial Infarction.	Journal of Cardiovascular Translational Research	2022
34778969	The mitochondrial regulator PGC1Î± is induced by cGMP-PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure.	FEBS Letters	2022
34324442	MLK3 mediates impact of PKG1Î± on cardiac function and controls blood pressure through separate mechanisms.	JCI Insight	2021
33464954	CRD-733, a Novel PDE9 (Phosphodiesterase 9) Inhibitor, Reverses Pressure Overload-Induced Heart Failure.	Circulation: Heart Failure	2021
32762903	Transvalvular Ventricular Unloading Before Reperfusion in AcuteÂ MyocardialÂ Infarction.	Journal of the American College of Cardiology	2020
31773461	Intermittent Occlusion of the Superior Vena Cava Reduces Cardiac Filling Pressures in Preclinical Models of Heart Failure.	Journal of Cardiovascular Translational Research	2020
32215350	Estrogen Receptor-Î± Non-Nuclear Signaling Confers Cardioprotection andÂ IsÂ Essential to cGMP-PDE5 InhibitionÂ Efficacy.	JACC: Basic to Translational Science	2020
30830222	Androgens Ameliorate Impaired Ischemia-Induced Neovascularization Due to Aging in Male Mice.	Endocrinology	2019
30362822	Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload.	American Journal of Physiology - Heart and Circulatory Physiology	2019
30586728	Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment-Elevation Myocardial Infarction.	Circulation	2019
31112633	First-in-human experience with occlusion of the superior vena cava to reduce cardiac filling pressures in congestive heart failure.	Catheterization and Cardiovascular Interventions	2019
29686001	Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II.	Hypertension	2018
29032225	Right Ventricular Dysfunction in Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Hemodynamic Analysis of the Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) Trial and Registry.	J Card Fail	2018
30354560	Abdominal Positioning of the Next-Generation Intra-Aortic Fluid Entrainment Pump (Aortix) Improves Cardiac Output in a Swine Model of Heart Failure.	Circulation: Heart Failure	2018
30010822	Selected Phytoestrogens Distinguish Roles of ERÎ± Transactivation and Ligand Binding for Anti-Inflammatory Activity.	Endocrinology	2018
30049311	Left Ventricular Unloading BeforeÂ Reperfusion Promotes FunctionalÂ Recovery After AcuteÂ MyocardialÂ Infarction.	J Am Coll Cardiol	2018
29764860	Membrane-Initiated Estrogen Receptor Signaling Mediates Metabolic Homeostasis via Central Activation of Protein Phosphatase 2A.	Diabetes	2018
29487140	Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure.	Circulation	2018
28213819	Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling.	Heart and Vessels	2017
28820968	Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.	Cardiovascular Pathology	2017
28554716	Acute Hemodynamic Effects of Intra-aortic Balloon Counterpulsation Pumps in Advanced Heart Failure.	Journal of Cardiac Failure	2017
27888004	Unliganded estrogen receptor alpha regulates vascular cell function and gene expression.	Mol Cell Endocrinol	2017
27614169	Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure.	Cardiovascular Pathology	2016
27442859	Distinct Effects of Left or Right Atrial Cannulation on Left Ventricular Hemodynamics in a Swine Model of Acute Myocardial Injury.	ASAIO Journal	2016
27114311	Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks.	Chin J Nat Med	2016
27068635	Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure.	J Am Heart Assoc	2016
27276022	MicroRNA-Offset RNA Alters Gene Expression and Cell Proliferation.	PLoS ONE	2016
27035664	ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.	PLoS One	2016
26022677	Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure.	Circulation: Heart Failure	2015
25485565	Hemodynamic effects of left atrial or left ventricular cannulation for acute circulatory support in a bovine model of left heart injury.	ASAIO Journal	2015
26442659	Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.	Nature Communications	2015
26351396	A new shield from the double-edged sword of reperfusion in STEMI.	European Heart Journal	2015
26541785	Mechanical Pre-Conditioning With Acute Circulatory Support Before Reperfusion Limits Infarct Size in Acute Myocardial Infarction.	JACC: Heart Failure	2015
24837433	PDE5 inhibitor efficacy is estrogen dependent in female heart disease.	Journal of Clinical Investigation	2014
25313857	Î³Î´T cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice.	PLoS ONE	2014
24411776	The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice.		2014
24336757	Lipoprotein-associated phospholipase A2, a novel cardiovascular inflammatory marker, in HIV-infected patients.	Clinical Infectious Diseases	2014
25051445	Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function.	Endocrinology	2014
23657971	Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.		2013
22982037	Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice.	J Thorac Cardiovasc Surg	2013
24079290	High-density lipoproteins: a consensus statement from the National Lipid Association.	J Clin Lipidol	2013
23766351	Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size.	Circulation	2013
23936252	Biventricular remodeling in murine models of right ventricular pressure overload.	PLoS ONE	2013
23744991	Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation.	Arterioscler Thromb Vasc Biol	2013
23921303	Vascular reactivity screen of Chinese medicine danhong injection identifies Danshensu as a NO-independent but PGI2-mediated relaxation factor.	Journal of Cardiovascular Pharmacology	2013
23276634	Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system.	Steroids	2013
23530304	Racial differences in central hemodynamic burden in men with HIV: preliminary findings.	Ethnicity and Disease	2013
23265337	The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.	Journal of the American College of Cardiology	2013