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Author Details

Traver Hart
University of Texas MD Anderson Cancer Center
2004
65
31
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38060314CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon.JCI Insight2024
36350677PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens.Nucleic Acids Res2023
37541219FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways.Mol Cell2023
37047518Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway.Int J Mol Sci2023
37426340Genome-wide CRISPR-Cas9 screen analyzed by SLIDER identifies network of repressor complexes that regulate TRIM24.iScience2023
36747082Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.Nat Cell Biol2023
36712129Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform.bioRxiv2023
36727483Recovering false negatives in CRISPR fitness screens with JLOE.Nucleic Acids Res2023
34747468HumanNet v3: an improved database of human gene networks for disease research.Nucleic Acids Res2022
35704761Integrated screens uncover a cell surface tumor suppressor gene <i>KIRREL</i> involved in Hippo pathway.Proc Natl Acad Sci U S A2022
35559673Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.Sci Adv2022
36443674Optimal construction of a functional interaction network from pooled library CRISPR fitness screens.BMC Bioinformatics2022
33407829Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier.Genome Med2021
34881774Common computational tools for analyzing CRISPR screens.Emerg Top Life Sci2021
34764293Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.Nat Commun2021
34475205AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase.Proc Natl Acad Sci U S A2021
34320214Genetic vulnerabilities upon inhibition of DNA damage response.Nucleic Acids Res2021
32300176Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition.Oncogene2020
31991288CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions.DNA Repair (Amst)2020
31881079IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.J Cell Biol2020
32004439Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.Neuron2020
33376220DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.Proc Natl Acad Sci U S A2020
33059726Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens.Genome Biol2020
32968282Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.Nature2020
32853826C17orf53 is identified as a novel gene involved in inter-strand crosslink repair.DNA Repair (Amst)2020
32709883Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun2020
30696911A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations.Sci Rep2019
31921397Chemogenetic interactions in human cancer cells.Comput Struct Biotechnol J2019
31316073Pooled library screening with multiplexed Cpf1 library.Nat Commun2019
31506018A consensus set of genetic vulnerabilities to ATR inhibition.Open Biol2019
30979825A network of human functional gene interactions from knockout fitness screens in cancer cells.Life Sci Alliance2019
30995489Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.Cell Rep2019
30418591HumanNet v2: human gene networks for disease research.Nucleic Acids Res2019
30532030Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.Oncogene2019
29224152Microdroplet PCR for Highly Multiplexed Targeted Bisulfite Sequencing.Methods Mol Biol2018
29973717CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature2018
30022168The shieldin complex mediates 53BP1-dependent DNA repair.Nature2018
30269036Expression of the miR-150 tumor suppressor is restored by and synergizes with rapamycin in a human leukemia T-cell line.Leuk Res2018
29077937PICKLES: the database of pooled in-vitro CRISPR knockout library essentiality screens.Nucleic Acids Res2018
27869803Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nat Med2017
29073370All for One, and One for All.Cell Syst2017
29117169Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.Nat Med2017
28655737Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.G3 (Bethesda)2017
27083490BAGEL: a computational framework for identifying essential genes from pooled library screens.BMC Bioinformatics2016
25576597Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.J Immunol2015
26627737High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Cell2015
26353928Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.Oncotarget2015
26673326Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells.Cell Rep2015
26186192Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.Cell2015
26208794Extensive mapping of an innate immune network with CRISPR.Mol Syst Biol2015
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Collaborators

Jason Moffat
University of Toronto
Co-authored papers 15
Junjie Chen
The University of Texas MD Anderson Cancer Center
Co-authored papers 11
Edward M Marcotte
University of Texas
Co-authored papers 10
Kevin R Brown
College Street, University of Toronto
Co-authored papers 8
Stephane Angers
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 7
Zachary Steinhart
Gladstone-UCSF Institute of Genomic Immunology
Co-authored papers 6
Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 5
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 4
Steven R Head
Co-authored papers 4
John G Doench
Co-authored papers 3
Graham MacLeod
University of Toronto
Co-authored papers 3
Hans Clevers
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Ali Torkamani
Scripps Science Institute
Co-authored papers 2
Amy Hin Yan Tong
University of Toronto
Co-authored papers 2
Nicole Hustedt
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Sichun Lin
Department of Pharmaceutical Sciences, University of Toronto
Co-authored papers 2
Phillip Ordoukhanian
Co-authored papers 2
Peter B Dirks
The Hospital for Sick Children, University of Toronto
Co-authored papers 2
Carolyn A Goard
Princess Margaret Cancer Centre, Ontario Cancer Institute
Co-authored papers 1
Charles Boone
University of Toronto
Co-authored papers 1
James Vlasblom
University of Regina
Co-authored papers 1
Sahil Seth
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Peter J Mullen
University of St Andrews
Co-authored papers 1
Yaoqi Alan Wang
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
Maryou B Lambros
The Institute of Cancer Research
Co-authored papers 1
Genevi??ve Lavoie
Institute for Research in Immunology and Cancer (IRIC)
Co-authored papers 1
Nora M Navone
MD Anderson Cancer Center
Co-authored papers 1
Florence M G Cavalli
Institut Curie, PSL Research University
Co-authored papers 1
Christoph J Fahrni
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Co-authored papers 1
Release 1.2