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Author Details

Huib Ovaa
Leiden University Medical Center
2002
219
66
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36377600In-Plate Chemical Synthesis of Isopeptide-Linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP Preferences.Chembiochem2023
38055744USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.Proc Natl Acad Sci U S A2023
37642399Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2.ACS Chem Biol2023
36966155Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.Nat Commun2023
34718348EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.Oncogene2022
35720124Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor.Front Mol Biosci2022
35811497USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII.EMBO J2022
36149939Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput.J Med Chem2022
35920208Total Chemical Synthesis of a Functionalized GFP Nanobody.Chembiochem2022
35149681Allosteric control of Ubp6 and the proteasome via a bidirectional switch.Nat Commun2022
34907316IMI European Lead Factory - democratizing access to high-throughput screening.Nat Rev Drug Discov2022
33482040Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.Chembiochem2021
33711480Quantifying Positional Isomers (QPI) by Top-Down Mass Spectrometry.Mol Cell Proteomics2021
33536622Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.Nature2021
33503430Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex.Cell Rep2021
33885283Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease.J Am Chem Soc2021
34533845Signal inhibitory receptor on leukocytes-1 recognizes bacterial and endogenous amphipathic α-helical peptides.FASEB J2021
34387015Development of Tyrphostin Analogues to Study Inhibition of the Mycobacterium tuberculosis Pup Proteasome System*.Chembiochem2021
34145909Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes-1 negatively regulates human neutrophils.Eur J Immunol2021
33972535Identification and characterization of a SARS-CoV-2 specific CD8<sup>+</sup> T cell response with immunodominant features.Nat Commun2021
33288957Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.Nat Chem Biol2021
33075184Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.Chemistry2021
33238157K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.Cell Chem Biol2021
32509738Editorial: Probing the Ubiquitin Landscape.Front Chem2020
31674341Cracking the Ubiquitin Code: The Ubiquitin Toolbox.Curr Issues Mol Biol2020
31857432Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis.Clin Cancer Res2020
32039151Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code.Front Chem2020
32039147Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1.Front Chem2020
33185526Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection.Elife2020
32605368Manno-<i>epi</i>-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors.J Am Chem Soc2020
32886496Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.J Am Chem Soc2020
33022275Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response.Mol Cell2020
32845033Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.EMBO J2020
32726803Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.Nature2020
32421893Synthesis of Stable NAD<sup>+</sup> Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC.Chembiochem2020
32188699Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.Genome Res2020
32154221Strategy for Development of Site-Specific Ubiquitin Antibodies.Front Chem2020
32381382Opportunities for Small Molecules in Cancer Immunotherapy.Trends Immunol2020
32196552Small molecules that target the ubiquitin system.Biochem Soc Trans2020
32426286Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD<sup>+</sup> Dependent Lysine Deacetylases.Front Oncol2020
32567101Identification and characterization of diverse OTU deubiquitinases in bacteria.EMBO J2020
30689386The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.J Am Chem Soc2019
31658303Nedd8 hydrolysis by UCH proteases in Plasmodium parasites.PLoS Pathog2019
31710063Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties.Org Biomol Chem2019
32110315Development of a DUB-selective fluorogenic substrate.Chem Sci2019
30178261How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling.Curr Top Microbiol Immunol2019
31381834Development of Ubiquitin-Based Probe for Metalloprotease Deubiquitinases.Angew Chem Int Ed Engl2019
31233270DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells.Angew Chem Int Ed Engl2019
31483102Production and Thermal Exchange of Conditional Peptide-MHC I Multimers.Curr Protoc Immunol2019
31482094Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes.Front Mol Biosci2019
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Collaborators

Farid El Oualid
The Netherlands Cancer Institute
Co-authored papers 18
Reggy Ekkebus
Netherlands Cancer Institute
Co-authored papers 12
Albert J R Heck
Utrecht University
Co-authored papers 7
Fred van Leeuwen
Netherlands Cancer Institute, University of Amsterdam
Co-authored papers 6
Ivan Dikic
Institute of Biochemistry II, Goethe University Frankfurt
Co-authored papers 5
Klaus-Peter Knobeloch
Co-authored papers 5
Tibor van Welsem
Netherlands Cancer Institute
Co-authored papers 4
Kenneth C Anderson
Dana Farber Cancer Institute
Co-authored papers 4
Christopher D Lima
Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Christoph Driessen
Cantonal Hospital St. Gallen
Co-authored papers 3
Iris J E Stulemeijer
Netherlands Cancer Institute
Co-authored papers 2
Aaron N Chang
Baylor College of Medicine
Co-authored papers 2
Tessy Korthout
Oncode Institute
Co-authored papers 2
Gerhard Hummer
Max Planck Institute of Biophysics
Co-authored papers 2
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 2
Steven P Gygi
Harvard Medical School
Co-authored papers 2
Anja Basters
Co-authored papers 2
Deepani W Poramba-Liyanage
Utrecht University Utrecht The Netherlands.
Co-authored papers 2
John T Chang
University of California San Diego
Co-authored papers 2
Kathleen M Fisch
Center for Computational Biology and Bioinformatics, University of California
Co-authored papers 2
Lewis E Kay
University of Toronto
Co-authored papers 1
Erin L P Bradley
Rollins School of Public Health, Emory University
Co-authored papers 1
David J McConkey
Johns Hopkins School of Medicine
Co-authored papers 1
Eri Sakata
Max Planck Institute of Biochemistry
Co-authored papers 1
Richard A Scheltema
Utrecht Institute for Pharmaceutical Sciences, Utrecht University
Co-authored papers 1
Emma J Birks
Co-authored papers 1
Rohith Srivas
Amgen Inc.
Co-authored papers 1
Haico van Attikum
Leiden University Medical Center
Co-authored papers 1
Michael H Glickman
Technion-Israel Institute of Technology
Co-authored papers 1
Paul J R Barton
Co-authored papers 1
Release 1.2