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Author Details

S??bastien Gibot
Centre Hospitalier Regional Universitaire (CHRU)
2002
134
44
PMIDPaper TitleJournal TitlePublished Year
35977699Circulating Endothelial Cells are Associated with Thromboembolic Events in Patients with Antiphospholipid Antibodies.Thromb Haemost2023
37706025Efficacy of Wharton Jelly Mesenchymal Stromal Cells infusions in moderate to severe SARS-Cov-2 related acute respiratory distress syndrome: a phase 2a double-blind randomized controlled trial.Front Med (Lausanne)2023
37574520Soluble TREM-1 plasma concentration predicts poor outcome in COVID-19 patients.Intensive Care Med Exp2023
37350989Evaluation of the efficacy and safety of TREM-1 inhibition with nangibotide in patients with COVID-19 receiving respiratory support: the ESSENTIAL randomised, double-blind trial.EClinicalMedicine2023
37269870Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial.Lancet Respir Med2023
36810101Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial.Crit Care2023
36687437Clinical outcomes and characteristics of critically ill patients with influenza- and COVID-19-induced ARDS: A retrospective, matched cohort study.Front Med (Lausanne)2023
36942789Hydrocortisone in Severe Community-Acquired Pneumonia.N Engl J Med2023
36699032Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity.Front Endocrinol (Lausanne)2023
35360736Comparison of SARS-CoV-2 Variants of Concern Alpha (B.1.1.7) vs. Beta (B.1.351) in Critically Ill Patients: A Multicenter Cohort Study.Front Med (Lausanne)2022
33420354Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis.Cell Mol Immunol2021
35844707Lactic acidosis and hypoglycemia as markers of disease progression of multiple myeloma: A case report.EJHaem2021
35004712Positive End-Expiratory Pressure Setting in COVID-19-Related Acute Respiratory Distress Syndrome: Comparison Between Electrical Impedance Tomography, PEEP/FiO<sub>2</sub> Tables, and Transpulmonary Pressure.Front Med (Lausanne)2021
34534607Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study.Int J Cardiol2021
34233965Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial.BMJ Open2021
34089117Mental health and stress among ICU healthcare professionals in France according to intensity of the COVID-19 epidemic.Ann Intensive Care2021
34195785Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19.Biosci Rep2021
34112941Obesity and mortality in critically ill COVID-19 patients with respiratory failure.Int J Obes (Lond)2021
34282296sTREM-1 is a specific biomarker of TREM-1 pathway activation.Cell Mol Immunol2021
32468087Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial.Intensive Care Med2020
32056017Feasibility, reproducibility and diagnostic usefulness of right ventricular strain by 2-dimensional speckle-tracking echocardiography in ARDS patients: the ARD strain study.Ann Intensive Care2020
32041533Viscerotropic disease and acute uveitis following yellow fever vaccination: a case report.BMC Infect Dis2020
31767118Emergence of antibodies endowed with proteolytic activity against High-mobility group box 1 protein (HMGB1) in patients surviving septic shock.Cell Immunol2020
31680426Inhibition of triggering receptor expressed on myeloid cells-1 impairs thrombin generation.J Thromb Haemost2020
31733681Soluble Triggering Receptor Expressed on Myeloid Cells-1: Diagnosis or Prognosis?Crit Care Clin2020
32808462Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19.Stem Cells Transl Med2020
32602969Comparison of sTREM-1 and associated periodontal and bacterial factors before/after periodontal therapy, and impact of psychosocial factors.J Clin Periodontol2020
32623470Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France.Clin Infect Dis2020
32984786The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design study.EClinicalMedicine2020
29568119TREM-1 multimerization is essential for its activation on monocytes and neutrophils.Cell Mol Immunol2019
30089551Endothelial-driven increase in plasma thrombin generation characterising a new hypercoagulable phenotype in acute heart failure.Int J Cardiol2019
31632399Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation.Front Immunol2019
31248453Bone marrow vs Wharton's jelly mesenchymal stem cells in experimental sepsis: a comparative study.Stem Cell Res Ther2019
30871305Automated measurement of neutrophil CD64 expression for diagnosing sepsis in critically ill patients.Minerva Anestesiol2019
30882551An enlarged left adrenal gland is an indirect sign of infection on 18F-FDG PET/CT.Nucl Med Commun2019
28726362Early hypertension after vasopressor weaning during septic shock: associated factors and prognostic significance.Minerva Anestesiol2018
29885068A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition.Br J Clin Pharmacol2018
30091119Clinical-grade mesenchymal stem cells derived from umbilical cord improve septic shock in pigs.Intensive Care Med Exp2018
30392084Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU.Ann Intensive Care2018
29779263Effects of Porphyromonas gingivalis LPS and LR12 peptide on TREM-1 expression by monocytes.J Clin Periodontol2018
29361046Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock.Cardiovasc Res2018
29721786Data-driving methods: More than merely trendy buzzwords?Ann Intensive Care2018
29155054Hospital-acquired pneumonia in ICU.Anaesth Crit Care Pain Med2018
28961797TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice.J Crohns Colitis2018
29138897Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study.Intensive Care Med2018
27790740LR12-peptide quantitation in whole blood by RP-HPLC and intrinsic fluorescence detection: Validation and pharmacokinetic study.Biomed Chromatogr2017
28232200One-week in vivo sustained release of a peptide formulated into in situ forming implants.Int J Pharm2017
28245991TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives.Pharmacol Ther2017
29116572Admission of tetanus patients to the ICU: a retrospective multicentre study.Ann Intensive Care2017
28837205Triggering Receptor Expressed on Myeloid cells-1: a new player in platelet aggregation.Thromb Haemost2017
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Collaborators

Centre Hospitalier Regional Mons-Hainaut
Co-authored papers 5
Center for Experimental and Molecular Medicine, University of Amsterdam
Co-authored papers 4
Radboud University Medical Centre
Co-authored papers 2
Bethune Hospital
Co-authored papers 2
INSERM UMR-S , Universite de Paris Cite
Co-authored papers 2
National Cancer Institute-Frederick
Co-authored papers 2
National Cancer Institute
Co-authored papers 2
University of Cincinnati College of Medicine
Co-authored papers 1
Utrecht University
Co-authored papers 1
Duke University
Co-authored papers 1
University of Helsinki and Helsinki University Hospital
Co-authored papers 1
Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
Edouard Herriot Hospital
Co-authored papers 1
Co-authored papers 1
CNRS URA 5
Co-authored papers 1
The George Institute for Global Health
Co-authored papers 1
Lausanne University Hospital
Co-authored papers 1
Co-authored papers 1
Amsterdam University Medical Centers
Co-authored papers 1