Author details

Full Name

Danwei Huangfu

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37419111	Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.	Mol Cell	2023
37961332	Decoding Heterogenous Single-cell Perturbation Responses.	bioRxiv	2023
37205540	Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal.		2023
37398096	Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells.		2023
36945628	Dynamic network-guided CRISPRi screen reveals CTCF loop-constrained nonlinear enhancer-gene regulatory activity in cell state transitions.		2023
36604594	MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state.		2023
37488417	Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions.		2023
37546906	ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.		2023
35058633	Abnormal exocrine-endocrine cell cross-talk promotes Î²-cell dysfunction and loss in MODY8.	Nat Metab	2022
35876795	A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation.	Biology Open	2022
35787684	CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction.	Nat Cell Biol	2022
36545154	Genetic Engineering of Immune Evasive Stem Cell-Derived Islets.		2022
34955367	Epigenome rewiring in human pluripotent stem cells.	Trends in Cell Biology	2022
34879277	Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.	Cell Rep	2021
33833093	QSER1 protects DNA methylation valleys from de novo methylation.	Science	2021
33561421	Kathryn Anderson (1952-2020).	Developmental Cell	2021
34193943	Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors.	Oncogene	2021
31407519	Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency.	Wiley Interdisciplinary Reviews: Systems Biology and Medicine	2020
32443951	Enhancer Predictions and Genome-Wide Regulatory Circuits.	Annual Review of Genomics and Human Genetics	2020
31110351	Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.	Nat Genet	2019
31291575	FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation.	Cell Reports	2019
31511848	Glutamine independence is a selectable feature of pluripotent stem cells.	Nature Metabolism	2019
29781950	Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.	Transplantation	2018
30146489	DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.	Stem Cell Reports	2018
29913329	Decoding the noncoding genome via large-scale CRISPR screens.	Current Opinion in Genetics and Development	2018
29992946	Discovery of a drug candidate for GLIS3-associated diabetes.	Nat Commun	2018
29255266	Publisher Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.	Nat Genet	2018
29255265	Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.	Nat Genet	2018
29203910	TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.	Nat Genet	2018
28196600	Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.		2017
28985525	CRISPR/Cas9-Based Engineering of the Epigenome.		2017
28287608	Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development.	Journal of Visualized Experiments	2017
27709569	CRISPR/Cas9-Mediated Mutagenesis of Human Pluripotent Stem Cells in Defined Xeno-Free E8 Medium.	Methods in Molecular Biology	2017
27807834	CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells.	Methods in Molecular Biology	2017
27889317	The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.		2017
26383234	Mechanisms underlying the formation of induced pluripotent stem cells.	Wiley Interdisciplinary Reviews: Developmental Biology	2016
27133796	Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.		2016
26028531	A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells.	Stem Cell Reports	2015
25798938	Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.	Nat Biotechnol	2015
24931489	An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.		2014
25398343	The iCRISPR platform for rapid genome editing in human pluripotent stem cells.	Methods in Enzymology	2014
25032261	Stem cell epigenetics: looking forward.	Cell Stem Cell	2014
23478019	Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.	Cell Reports	2013
23362344	Human pluripotent stem cells: an emerging model in developmental biology.	Development (Cambridge)	2013
20823063	Glucose and aging control the quiescence period that follows pancreatic beta cell replication.	Development	2010
19818703	A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.		2009
18849973	Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.	Nat Biotechnol	2008
18568017	Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.	Nat Biotechnol	2008
17535113	All beta cells contribute equally to islet growth and maintenance.	PLoS Biol	2007
16339192	Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates.	Development (Cambridge)	2006