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Author Details

Chris Twelves
Leeds Teaching Hospitals NHS Trust, University of Leeds
1986
267
64
PMIDPaper TitleJournal TitlePublished Year
36757526Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search.J Neurooncol2023
37085049Persistence of immune responses after heterologous and homologous third COVID-19 vaccine dose schedules in the UK: eight-month analyses of the COV-BOOST trial.J Infect2023
37055303Corrigendum to "Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial" [J Infect 84(6) (2022) 795-813, 5511].J Infect2023
36859649Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study.Breast Cancer Res Treat2023
34844889The Place of Chemotherapy in The Evolving Treatment Landscape for Patients With HR-positive/HER2-negative MBC.Clin Breast Cancer2022
35800293A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigoâ¿¢) in breast cancer patients with BONe metastases: CARBON trial results.J Bone Oncol2022
35405168Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial.J Infect2022
35439304Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients.Cancer Immunol Res2022
35702414Timelines to initiate a phase III trial across the globe: a sub-analysis of the APHINITY trial.Ecancermedicalscience2022
35671774Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial.Lancet Oncol2022
35552364Treatment With Etirinotecan Pegol for Patients With Metastatic Breast Cancer and Brain Metastases: Final Results From the Phase 3 ATTAIN Randomized Clinical Trial.JAMA Oncol2022
32835356Sex and Adverse Events of Adjuvant Chemotherapy in Colon Cancer: An Analysis of 34â¿¿640 Patients in the ACCENT Database.J Natl Cancer Inst2021
33850304Determining lines of therapy in patients with solid cancers: a proposed new systematic and comprehensive framework.Br J Cancer2021
34850894Cancer Treatment: Preclinical & Clinical.J Natl Cancer Inst Monogr2021
34043927Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in breast cancer therapeutics.Expert Opin Biol Ther2021
32161368Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours.Br J Cancer2020
31964373Systemic treatment of hormone receptor positive, human epidermal growth factor 2 negative metastatic breast cancer: retrospective analysis from Leeds Cancer Centre.BMC Cancer2020
31782589Impact of the number of prior chemotherapy regimens on outcomes for patients with metastatic breast cancer treated with eribulin: A post hoc pooled analysis.Breast J2020
32035020Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial.Lancet Oncol2020
31941523CApecitabine plus Radium-223 (Xofigoâ¿¢) in breast cancer patients with BONe metastases (CARBON): study protocol for a phase IB/IIA randomised controlled trial.Trials2020
33072895CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell lung cancer.Clin Transl Radiat Oncol2020
32572174Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy.Br J Cancer2020
32897732Reimagining Global Oncology Clinical Trials for the Postpandemic Era: A Call to Arms.JCO Glob Oncol2020
32641747Efficacy of eribulin for metastatic breast cancer based on localization of specific secondary metastases: a post hoc analysis.Sci Rep2020
30783204A phase 1b/2, open-label, dose-escalation, and dose-confirmation study of eribulin mesilate in combination with capecitabine.Br J Cancer2019
31302407Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance.Crit Rev Oncol Hematol2019
31189729Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models.J Pharmacol Exp Ther2019
31074641ATTAIN: Phase III study of etirinotecan pegol versus treatment of physician's choice in patients with metastatic breast cancer and brain metastases.Future Oncol2019
30976844Pharmacokinetic and exploratory exposure-response analysis of pertuzumab in patients with operable HER2-positive early breast cancer in the APHINITY study.Cancer Chemother Pharmacol2019
29119333Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam.Eur J Drug Metab Pharmacokinet2018
29618616Change in Topoisomerase 1-Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol.Clin Cancer Res2018
29525430The Global Need for a Trastuzumab Biosimilar for Patients With HER2-Positive Breast Cancer.Clin Breast Cancer2018
29329006Ongoing unmet needs in treating estrogen receptor-positive/HER2-negative metastatic breast cancer.Cancer Treat Rev2018
29298869Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.Sci Transl Med2018
28550999Process mining routinely collected electronic health records to define real-life clinical pathways during chemotherapy.Int J Med Inform2017
28360015Health-related quality of life in patients with locally recurrent or metastatic breast cancer treated with etirinotecan pegol versus treatment of physician's choice: Results from the randomised phase III BEACON trial.Eur J Cancer2017
28573005Drug delivery in a tumour cord model: a computational simulation.R Soc Open Sci2017
28884461Erratum to: Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.Breast Cancer Res Treat2017
28612225Prolonged survival in patients with breast cancer and a history of brain metastases: results of a preplanned subgroup analysis from the randomized phase III BEACON trial.Breast Cancer Res Treat2017
26783036Characterizing and quantifying the effects of breast cancer therapy using mathematical modeling.Breast Cancer Res Treat2016
27392074The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.PLoS One2016
27441152Safety and tolerability of etirinotecan pegol in advanced breast cancer: analysis of the randomized, phase 3 BEACON trial.Springerplus2016
27225692A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma.Clin Cancer Res2016
27398025Subgroup Analyses from a Phase 3, Open-Label, Randomized Study of Eribulin Mesylate Versus Capecitabine in Pretreated Patients with Advanced or Metastatic Breast Cancer.Breast Cancer (Auckl)2016
26858337Determinants of Early Mortality Among 37,568 Patients With Colon Cancer Who Participated in 25 Clinical Trials From the Adjuvant Colon Cancer Endpoints Database.J Clin Oncol2016
26857987Cytotoxic chemotherapy: Still the mainstay of clinical practice for all subtypes metastatic breast cancer.Crit Rev Oncol Hematol2016
26852132Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.Breast Cancer Res2016
26734784'Tablet burden' in patients with metastatic breast cancer.Eur J Cancer2016
27050076Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro.Oncotarget2016
25595934Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized, controlled trials.Ann Oncol2015
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Collaborators

University of Edinburgh
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Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
Co-authored papers 11
Warwick Clinical Trials Unit, University of Warwick
Co-authored papers 8
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 7
Dartmouth Cancer Center
Co-authored papers 7
Institute of Cancer and Genomic Sciences, The University of Birmingham
Co-authored papers 7
The Institute for Cancer Research
Co-authored papers 6
Center for Cancer Genetic Epidemiology, University of Cambridge
Co-authored papers 6
NSABP Foundation
Co-authored papers 6
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 5
Mayo Clinic
Co-authored papers 4
University of Oxford
Co-authored papers 4
Champalimaud Clinical Center/Champalimaud Foundation
Co-authored papers 4
UCL Great Ormond Street Institute of Child Health, University College London
Co-authored papers 3
College of Agriculture and Life Sciences, Cornell University
Co-authored papers 3
Queens University
Co-authored papers 3
The Institute of Cancer Research
Co-authored papers 3
GZA Ziekenhuizen Campus Sint-Augustinus, University of Antwerp
Co-authored papers 3
Ontario Institute for Cancer Research
Co-authored papers 3
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Promontory Therapeutics Inc.
Co-authored papers 2
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 2
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University of California los angeles
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Mayo Clinic
Co-authored papers 2
University of Edinburgh
Co-authored papers 2
Leuven Cancer Institute and University Hospitals Leuven
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Ohio State University
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Dana-Farber Cancer Institute
Co-authored papers 2
University of Glasgow
Co-authored papers 2