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Author Details

Caitlin M O'Connor
2017
15
8
PMIDPaper TitleJournal TitlePublished Year
36788429Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death.Mol Cancer Ther2023
37644036Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.Nat Commun2023
37166997PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.J Clin Invest2023
34921012Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma.Cancer Res2022
36328247Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules.J Biol Chem2022
31541192Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors.Oncogene2020
32315618Selective PP2A Enhancement through Biased Heterotrimer Stabilization.Cell2020
32482664Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis.Cancer Discov2020
33027304The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.PLoS One2020
30796164Protein phosphatase 2A Aα regulates Aβ protein expression and stability.J Biol Chem2019
31562245Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45).J Biol Chem2019
31142515The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.Cancer Res2019
29107183Therapeutic targeting of PP2A.Int J Biochem Cell Biol2018
30021885PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.Sci Transl Med2018
28504649Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.J Clin Invest2017
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