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| 36594833 | Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. | | 2023 |
| 36402263 | Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by suppressing Myc targets. | | 2023 |
| 35352560 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies. | J Med Chem | 2022 |
| 33208184 | Correction to: Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia. | Clin Epigenetics | 2020 |
| 32169966 | Editor's Note: Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-mediated Potentiation of Bortezomib-induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells. | Clinical Cancer Research | 2020 |
| 29244490 | Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). | J Med Chem | 2018 |
| 29562800 | Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. | SLAS Discov | 2018 |
| 28092155 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. | J Med Chem | 2017 |
| 28767039 | FXR1 regulates transcription and is required for growth of human cancer cells with <i>TP53/FXR2</i> homozygous deletion. | Elife | 2017 |
| 29156705 | Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells. | Oncotarget | 2017 |
| 28072869 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED. | PLoS One | 2017 |
| 28249907 | HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2<sup>+</sup> Tumors. | Cancer Res | 2017 |
| 28135235 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. | Nat Chem Biol | 2017 |
| 27543593 | Histone deacetylase inhibitors activate NF-κB in human leukemia cells through an ATM/NEMO-related pathway. | Journal of Biological Chemistry | 2016 |
| 26822688 | Current trends in outwitting resistance development in Candida infections through photodynamic and short peptide therapies: a strategic-shift from conventional antifungal agents. | Expert Review of Anti-Infective Therapy | 2016 |
| 27642069 | Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling. | Cell Chem Biol | 2016 |
| 26160163 | SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells. | Genome Research | 2015 |
| 25628765 | Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia. | Clin Epigenetics | 2015 |
| 25728001 | A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferaseâ¿¿3 (PRMT3). | Angew Chem Int Ed Engl | 2015 |
| 26479923 | High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response. | Nat Med | 2015 |
| 26471002 | Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53. | Nat Commun | 2015 |
| 25166916 | Absolute quantification of histone PTM marks by MRM-based LC-MS/MS. | Anal Chem | 2014 |
| 24389101 | Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. | Mol Cell | 2014 |
| 24415537 | Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. | Blood | 2014 |
| 23569248 | Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. | Proceedings of the National Academy of Sciences of the United States of America | 2013 |
| 24030150 | Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma. | Cell Death Dis | 2013 |
| 23980095 | NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma. | Cancer Research | 2013 |
| 23963286 | The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity. | Melanoma Research | 2013 |
| 23681230 | SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. | Cell Death and Disease | 2013 |
| 23385375 | Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies. | Leukemia | 2013 |
| 23232026 | Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer. | Oncotarget | 2012 |
| 22932665 | Superior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells. | Clinical Cancer Research | 2012 |
| 22392915 | The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin. | Clinical Cancer Research | 2012 |
| 22344701 | Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589). | Drug Metabolism and Disposition | 2012 |
| 22838941 | Analysis of pan-African Centres of excellence in health innovation highlights opportunities and challenges for local innovation and financing in the continent. | BMC Int Health Hum Rights | 2012 |
| 22342622 | Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay. | Analytical Biochemistry | 2012 |
| 22916295 | ING1 and 5-azacytidine act synergistically to block breast cancer cell growth. | PLoS ONE | 2012 |
| 22367781 | Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. | Molecular Cancer Therapeutics | 2012 |
| 23236167 | Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. | Proc Natl Acad Sci U S A | 2012 |
| 22087262 | Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expression. | PLoS One | 2011 |
| 21078383 | Induction of cell cycle arrest and DNA damage by the HDAC inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells. | Free Radic Biol Med | 2011 |
| 21141730 | HDAC inhibitors and cancer therapy. | Progress in Drug Research | 2011 |
| 20715169 | Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat. | Int J Cancer | 2011 |
| 21723733 | Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. | Bioorganic and Medicinal Chemistry | 2011 |
| 21880715 | Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation. | Journal of Biological Chemistry | 2011 |
| 22132182 | Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling. | PLoS One | 2011 |
| 21742496 | The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. | Bioorg Med Chem Lett | 2011 |
| 21650221 | Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors. | J Med Chem | 2011 |
| 20634887 | Polycomb target genes are silenced in multiple myeloma. | PLoS ONE | 2010 |
| 20810927 | Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists. | Blood | 2010 |