Author details

Full Name

Andres E Leschziner

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36692009	Structures of human dynein in complex with the lissencephaly 1 protein, LIS1.		2023
38039358	Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.		2023
37978300	Author Correction: Structure and dynamics of the ASB9 CUL-RING E3 Ligase.		2023
37857821	Structure of LRRK1 and mechanisms of autoinhibition and activation.	Nat Struct Mol Biol	2023
34994688	Structural basis for cytoplasmic dynein-1 regulation by Lis1.	eLife	2022
36510024	Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules.		2022
34423856	Structural Biology of LRRK2 and its Interaction with Microtubules.	Movement Disorders	2021
34385683	Structures and function of the amino acid polymerase cyanophycin synthetase.	Nature Chemical Biology	2021
34709521	Structure Analysis of Proteins and Peptides by Difference Circular Dichroism Spectroscopy.	Protein Journal	2021
32513959	Structure and dynamics of the ASB9 CUL-RING E3 Ligase.	Nature Communications	2020
32341549	LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes.	Nature Cell Biology	2020
32989164	Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.	Proc Natl Acad Sci U S A	2020
31200019	3.1 Ã¿ structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids.	J Struct Biol	2019
31464684	A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex.	eLife	2019
29809203	Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase.	Communications Biology	2018
29864529	cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud.	J Struct Biol	2018
29168508	Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.	Nature	2017
28432788	Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding.	Elife	2017
28886386	Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein.	Cell	2017
26436706	Mechanism and regulation of cytoplasmic dynein.	Annual Review of Cell and Developmental Biology	2015
25955969	Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud.	eLife	2015
25061224	Traffic control: adaptor proteins guide dynein-cargo takeoff.	EMBO Journal	2014
25380312	Lis1 regulates dynein by sterically blocking its mechanochemical cycle.	eLife	2014
24034246	Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1.	Cell	2013
23065903	Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold.	Science	2012
22939623	Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor.	Cell	2012
22997337	Structural basis for microtubule binding and release by dynein.	Science	2012
22040801	Electron microscopy studies of nucleosome remodelers.	Current Opinion in Structural Biology	2011
21536134	Validation of the orthogonal tilt reconstruction method with a biological test sample.	J Struct Biol	2011
21172029	Introduction of customized inserts for s-treamlined assembly and optimization of BioBrick synthetic genetic circuits.	J Biol Eng	2010
20888964	The orthogonal tilt reconstruction method.	Methods in Enzymology	2010
19745151	A dimeric structure for archaeal box C/D small ribonucleoproteins.	Science	2009
17201674	Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions.		2007
17643123	Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms.	Nat Struct Mol Biol	2007
17360331	Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method.	Proc Natl Acad Sci U S A	2007
16829958	Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.	Nat Struct Mol Biol	2006
16431136	The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles.	Journal of Structural Biology	2006
15698570	Structural studies of the human PBAF chromatin-remodeling complex.	Structure	2005
14527421	The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates.	Molecular Cell	2003
11349126	Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate.	Journal of Biological Chemistry	2001
11583624	A model for the gamma delta resolvase synaptic complex.	Molecular Cell	2001
10617107	Neural regulation of alpha-dystroglycan biosynthesis and glycosylation in skeletal muscle.	Journal of Neurochemistry	2000
10481025	In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis.	Nucleic Acids Research	1999
9636151	Tn552 transposase catalyzes concerted strand transfer in vitro.	Proceedings of the National Academy of Sciences of the United States of America	1998
8548793	DNA transposition: from a black box to a color monitor.	Cell	1995
7596288	The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions.	Molecular Microbiology	1995