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Author Details

Seigo Izumo
Beth Israel Deaconess Medical Center.
1984
170
85
PMIDPaper TitleJournal TitlePublished Year
33495398Correction for McMullen et al., "Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy".Mol Cell Biol2021
28111276Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes.Stem Cell Reports2017
22228770Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.J Biol Chem2012
20237330PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.Arterioscler Thromb Vasc Biol2010
20847309Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.Circ Res2010
19122165Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.Am J Physiol Heart Circ Physiol2009
20082935Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction.J Am Coll Cardiol2009
19679877Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.Am J Pathol2009
19544447Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells.Stem Cells2009
18267957Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism.Cardiovasc Res2008
18688045Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.Circ Res2008
17250822Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.Dev Biol2007
17908558A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.Cell Metab2007
17904155Resistin, an adipocytokine, offers protection against acute myocardial infarction.J Mol Cell Cardiol2007
17604724A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.Cell2007
17660828Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.Nat Med2007
17202264Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.Proc Natl Acad Sci U S A2007
16469952Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.Arterioscler Thromb Vasc Biol2006
17019808Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy.Novartis Found Symp2006
16762803Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.J Card Fail2006
16716207Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses.BMC Genet2006
16983087Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure.Proc Natl Acad Sci U S A2006
16914500Development of heart valves requires Gata4 expression in endothelial-derived cells.Development2006
15673394Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation.J Cardiovasc Electrophysiol2005
16227599Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.Mol Cell Biol2005
16298682Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.Free Radic Biol Med2005
15902305Morphogenesis of the right ventricle requires myocardial expression of Gata4.J Clin Invest2005
15850572Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants.J Mol Cell Cardiol2005
15972800Haploinsufficiency of the cardiac transcription factor Nkx2-5 variably affects the expression of putative target genes.FASEB J2005
15623566Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats.Physiol Genomics2005
14597618The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.J Biol Chem2004
15226426Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.Mol Cell Biol2004
15184287Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload.Circulation2004
15464586GATA4 is a dosage-sensitive regulator of cardiac morphogenesis.Dev Biol2004
15368343Function follows form: cardiac conduction system defects in Nkx2-5 mutation.Anat Rec A Discov Mol Cell Evol Biol2004
15368344Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC.Anat Rec A Discov Mol Cell Evol Biol2004
15001440Alterations in apoptosis regulatory factors during hypertrophy and heart failure.Am J Physiol Heart Circ Physiol2004
15085192Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.J Clin Invest2004
14679301Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies.Physiol Genomics2004
12754203Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart.J Biol Chem2003
14507992Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy.Proc Natl Acad Sci U S A2003
12956333Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans.Novartis Found Symp2003
14595838Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.Genesis2003
14551244Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.Circ Res2003
14645532Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis.Mol Cell Biol2003
12663489NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro.Circ Res2003
12676539Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes.J Mol Cell Cardiol2003
12668503Rapamycin attenuates load-induced cardiac hypertrophy in mice.Circulation2003
12727144Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases.Trends Mol Med2003
11809903Elucidating the molecular and genetic interactions responsible for congenital heart disease.Pediatr Res2002
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Collaborators

Beth Israel Deaconess Medical Center.
Co-authored papers 20
Baker Heart and Diabetes Institute
Co-authored papers 20
Beth Israel Deaconess Medical Center, Harvard Medical School
Co-authored papers 18
Novartis Institutes for BioMedical Research, Inc. Cambridge
Co-authored papers 12
Beth Israel Deaconess Medical Center
Co-authored papers 12
Boston Children's Hospital, Harvard Medical School
Co-authored papers 10
Harvard Medical School, Boston Children's Hospital.
Co-authored papers 9
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 8
Beth Israel Deaconess Medical Center RN380F
Co-authored papers 7
Co-authored papers 6
Boston Children's Hospital
Co-authored papers 5
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
Co-authored papers 5
Co-authored papers 5
Beth Israel Deaconess Medical Center
Co-authored papers 5
Brigham and Women's Hospital (Y.K.
Co-authored papers 4
Harvard Medical School
Co-authored papers 4
Medical University of Graz
Co-authored papers 4
Duke Clinical Research Institute, Duke University
Co-authored papers 4
Co-authored papers 3
Nova Scotia Health Authority
Co-authored papers 3
Leeds Institute of Medical Research, University of Leeds
Co-authored papers 3
Co-authored papers 3
Former employee of Portola Pharmaceuticals
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Dartmouth Medical School
Co-authored papers 2
Wolfson Children's Hospital
Co-authored papers 2
Co-authored papers 2
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
Benioff Children's Hospital, University of California san francisco
Co-authored papers 2