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Author Details

Jean-Pierre J Issa
Fels Cancer Institute for Personalized Medicine, Temple University School of Medicine
1993
342
112
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36928921A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.Clin Cancer Res2023
37276510Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study.Blood Adv2023
36572998Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa.Epigenetics2023
36797759DNA methylation entropy as a measure of stem cell replication and aging.Genome Biol2023
36764492TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.Gastroenterology2023
36658621Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells.Clin Epigenetics2023
36219239Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer.Cancer Prev Res (Phila)2022
35507690Prospective comparison of outcomes with azacitidine and decitabine in patients with AML ineligible for intensive chemotherapy.Blood2022
35373289The Two-Hit Hypothesis Meets Epigenetics.Cancer Res2022
35884401Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells.Cancers (Basel)2022
36222848Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine.Clin Cancer Res2022
31451749Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.Mol Psychiatry2021
33514726Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas.Nat Commun2021
34209564The Roles of DNA Demethylases in Triple-Negative Breast Cancer.Pharmaceuticals (Basel)2021
34022936Accelerated aging in normal breast tissue of women with breast cancer.Breast Cancer Res2021
33220403High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.J Nutr Biochem2021
33452255Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) improves prediction of gene expression.Nat Commun2021
32398127Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis.Clin Epigenetics2020
30784602Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis.Cell Rep2019
31767039DNA methylation aging clocks: challenges and recommendations.Genome Biol2019
31331399Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.Clin Epigenetics2019
30833613Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.Sci Rep2019
31060979Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial.Lancet Haematol2019
30753828Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf<sup>V600E</sup>-Induced Tumorigenesis.Cancer Cell2019
28836271Roadmap for investigating epigenome deregulation and environmental origins of cancer.Int J Cancer2018
29891505TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer.Cancer Res2018
29875269Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.J Neurosci2018
30454645Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.Cell2018
29556023Demethylator phenotypes in acute myeloid leukemia.Leukemia2018
29211308Dose, schedule, safety, and efficacy of guadecitabine in relapsed or refractory acute myeloid leukemia.Cancer2018
29224148Digital Restriction Enzyme Analysis of Methylation (DREAM).Methods Mol Biol2018
28074068A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.Leukemia2017
28412585The promise of epigenetic therapy: reprogramming the cancer epigenome.Curr Opin Genet Dev2017
28159832DNA Hypomethylating Drugs in Cancer Therapy.Cold Spring Harb Perspect Med2017
28115406Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.Cancer Epidemiol Biomarkers Prev2017
29242551Ezh2 phosphorylation state determines its capacity to maintain CD8<sup>+</sup> T memory precursors for antitumor immunity.Nat Commun2017
28912502Caloric restriction delays age-related methylation drift.Nat Commun2017
28531272A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.Nucleic Acids Res2017
28926424Introduction: Cancer as an Epigenetic Disease.Cancer J2017
28926426Epigenetics and Precision Oncology.Cancer J2017
28844816Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial.Lancet Oncol2017
27879268Transcriptional Selectivity of Epigenetic Therapy in Cancer.Cancer Res2017
27980103Repositioning FDA-Approved Drugs in Combination with Epigenetic Drugs to Reprogram Colon Cancer Epigenome.Mol Cancer Ther2017
27022771Diet, Nutrition, and Cancer Epigenetics.Annu Rev Nutr2016
26480922Healthcare utilization and costs associated with tyrosine kinase inhibitor switching in patients with chronic myeloid leukemia.Leuk Lymphoma2016
27629931Targeting the cancer epigenome for therapy.Nat Rev Genet2016
27542211Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin.Oncotarget2016
26890396Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas.Epigenetics2016
26719529Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer.Cancer Res2016
26712470Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.Toxicol Appl Pharmacol2016
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Collaborators

The University of Texas MD Anderson Cancer Center
Co-authored papers 62
MD Anderson Cancer Center
Co-authored papers 41
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Co-authored papers 38
Georgia Cancer Center
Co-authored papers 21
University of Texas M.D. Anderson Cancer Center
Co-authored papers 21
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Co-authored papers 18
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Co-authored papers 16
Sainte-Justine University Hospital Research Center
Co-authored papers 10
Novant Health Cancer Institute - Elizabeth
Co-authored papers 9
MD Anderson Cancer Center
Co-authored papers 7
The University of Texas MD Anderson Cancer Center
Co-authored papers 7
College of Health Solutions, Arizona State University
Co-authored papers 7
Co-authored papers 6
Co-authored papers 6
University of Michigan Rogel Cancer Center.
Co-authored papers 5
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 5
University of Texas MD Anderson Cancer Center
Co-authored papers 5
University of Texas Health San Antonio (UTHSA)
Co-authored papers 5
MD Anderson Cancer Center
Co-authored papers 5
MD Anderson Cancer Center
Co-authored papers 4
Moores Cancer Center, university of california san diego
Co-authored papers 4
Co-authored papers 4
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
Wonju Severance Christian Hospital
Co-authored papers 4
The University of Chicago
Co-authored papers 3
Johns Hopkins School of Medicine
Co-authored papers 3
Baylor College of Medicine
Co-authored papers 3
University of Texas MD Anderson Cancer Center
Co-authored papers 3