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Author Details

Markus Warmuth
1988
62
42
PMIDPaper TitleJournal TitlePublished Year
31164653Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.Nat Commun2019
31582562The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.Journal of Biological Chemistry2019
30559381Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Nature2019
30386887Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).Cancer Chemotherapy and Pharmacology2019
30368584Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers.Cancer Chemotherapy and Pharmacology2019
30635584Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.Nat Commun2019
29457796H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.Nature Medicine2018
30137981Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.Journal of Medicinal Chemistry2018
29991605Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα and ERα Breast Cancer.Cancer Discovery2018
29247039H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.Cancer Research2017
28541300Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.Nat Commun2017
28329763The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.Nature2017
28740126Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.Nat Commun2017
29296742Novel in-frame deletions result in aberrant RNA splicing in CLL patients.Blood advances2017
29121062Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion.PLoS ONE2017
27362227Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.Nature2016
26710000Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms.Journal of Visualized Experiments2015
26565915Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.Cell Rep2015
25058389NAMPT is the cellular target of STF-31-like small-molecule probes.ACS Chem Biol2014
25376106Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.Org Lett2014
23742252Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.J Med Chem2013
22130798Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.Blood2012
22460905The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.Nature2012
21949247Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.Proc Natl Acad Sci U S A2011
21324920Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.Cancer Research2011
21892161Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.Nat Genet2011
20670954The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.Cancer Research2010
24900187Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist.ACS Medicinal Chemistry Letters2010
21076395Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Nat Med2010
20881279Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.Sci Transl Med2010
20930519Allosteric inhibition of BCR-ABL.Cell Cycle2010
20928937Hedgehog pathway activation in chronic myeloid leukemia.Cell Cycle2010
20530672The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.Cancer Research2010
20604564A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl.J Med Chem2010
20072125Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature2010
20152788Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.Biochim Biophys Acta2010
20237469Targeted cancer therapies in the twenty-first century: lessons from imatinib.Clinical Pharmacology and Therapeutics2010
19150426A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.Mol Cell2009
18772113Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.Cancer Cell2008
23484970Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies.Expert Opinion on Drug Discovery2008
17960378Role of p21(WAF1/CIP1) as an attenuator of both proliferative and drug-induced apoptotic signals in BCR-ABL-transformed hematopoietic cells.Annals of Hematology2008
18667312Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.Bioorg Med Chem Lett2008
17133113Ba/F3 cells and their use in kinase drug discovery.Current Opinion in Oncology2007
17632527Essential role of stromally induced hedgehog signaling in B-cell malignancies.Nature Medicine2007
17621874B-Raf kinase inhibitors for cancer treatment.Current Opinion in Investigational Drugs2007
17668209Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner.Annals of Hematology2007
17185414Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.Proc Natl Acad Sci U S A2007
16492761An efficient rapid system for profiling the cellular activities of molecular libraries.Proc Natl Acad Sci U S A2006
24980528Profiling the kinome for drug discovery.Drug Discov Today Technol2006
16873026A general strategy for creating "inactive-conformation" abl inhibitors.Chem Biol2006
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