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Author Details

Daniel Durocher
The Lunenfeld-Tannenbaum Research Institute, Mount Sinai Hospital
1995
118
62
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37306046An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for shieldin activity.EMBO Rep2023
37478847Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens.Mol Cell2023
37188479Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.Life Sci Alliance2023
35758262Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number.Elife2022
35444283CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.Nature2022
35842428The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.Nat Commun2022
34301934Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.Nat Commun2021
33795234Synthetic Lethality in Cancer Therapeutics: The Next Generation.Cancer Discov2021
33598657Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library.STAR Protoc2021
35121901The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer.Nat Cancer2021
34993463Bidirectional Ventricular Tachycardia in a Patient With Fulminant Myocarditis Secondary to Cardiac Sarcoidosis Mimicking Giant Cell Myocarditis.CJC Open2021
34819670FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.Nature2021
32558186SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus.EMBO Rep2020
33277478A substrate binding model for the KEOPS tRNA modifying complex.Nat Commun2020
32778845Functional characterization of a PROTAC directed against BRAF mutant V600E.Nat Chem Biol2020
30704900BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.Mol Cell2019
31467087Control of homologous recombination by the HROB-MCM8-MCM9 pathway.Genes Dev2019
31506018A consensus set of genetic vulnerabilities to ATR inhibition.Open Biol2019
30948458Shieldin - the protector of DNA ends.EMBO Rep2019
29176614Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.Nat Biotechnol2018
29973717CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.Nature2018
29807908Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.Mol Syst Biol2018
30022168The shieldin complex mediates 53BP1-dependent DNA repair.Nature2018
3002215853BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.Nature2018
27903914Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.Nucleic Acids Res2017
28406400The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.Elife2017
28242625ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.Genes Dev2017
29203878ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.Nat Commun2017
28826474A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres.Elife2017
28847817Reading chromatin signatures after DNA double-strand breaks.Philos Trans R Soc Lond B Biol Sci2017
28655737Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.G3 (Bethesda)2017
27768182Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.JAMA Oncol2017
26829389DNA damage signalling targets the kinetochore to promote chromatin mobility.Nat Cell Biol2016
27612511Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells.Biol Open2016
28008184The control of DNA repair by the cell cycle.Nat Cell Biol2016
2771648653BP1 Goes Back to Its p53 Roots.Mol Cell2016
27302132Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.Nucleic Acids Res2016
27462807The structural basis of modified nucleosome recognition by 53BP1.Nature2016
27153538The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.Mol Cell2016
26774285HELB Is a Feedback Inhibitor of DNA End Resection.Mol Cell2016
25799990MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection.Nature2015
26627737High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.Cell2015
26649820A mechanism for the suppression of homologous recombination in G1 cells.Nature2015
26527279Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.Mol Cell2015
26205667Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.Nat Commun2015
24652939Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.Science2014
25164867Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.Nat Commun2014
24815189Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.Cell Signal2014
24587176RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.PLoS One2014
24603765Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.PLoS Genet2014
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Collaborators

Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 11
Stephen P Jackson
Mission Therapeutics Ltd. Glenn Berge Building
Co-authored papers 8
Sarah Galicia
Co-authored papers 7
Dheva Setiaputra
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 7
Mike Tyers
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Co-authored papers 7
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University of Toronto
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Michael Downey
Ottawa Institute of Systems Biology, University of Ottawa
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Robert G Bristow
University of Toronto
Co-authored papers 5
Traver Hart
University of Texas MD Anderson Cancer Center
Co-authored papers 5
Nicole Hustedt
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 5
Daniel Y L Mao
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 4
Grant W Brown
University of Toronto, 1 King's College Circle
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Sunnybrook Research Institute
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Repare Therapeutics Inc.
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University of Toronto
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Alessandro Datti
University of Perugia
Co-authored papers 3
Frederick P Roth
University of Toronto
Co-authored papers 3
Sachdev S Sidhu
School of Pharmacy, University of Waterloo
Co-authored papers 3
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 3
Charles Boone
University of Toronto
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Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
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Jos Jonkers
Oncode Institute, Netherlands Cancer Institute
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Brian Raught
Princess Margaret Cancer Centre, University Health Network
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Kevin R Brown
College Street, University of Toronto
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Release 1.2