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Author Details

Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
1997
161
64
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36929026Solubilization mechanism of self-assembled walnut protein nanoparticles and curcumin encapsulation.J Sci Food Agric2023
37487103Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM.Proc Natl Acad Sci U S A2023
37546986Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.bioRxiv2023
37573365Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.Nat Commun2023
37384669Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.Science2023
37163603Dodecamer assembly of a metazoan AAA<sup>+</sup> chaperone couples substrate extraction to refolding.Sci Adv2023
36754086The structural basis for HIV-1 Vif antagonism of human APOBEC3G.Nature2023
36807264The Ï¿PA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice.Nat Commun2023
34711980Selective G protein signaling driven by substance P-neurokinin receptor dynamics.Nat Chem Biol2022
35740889Allostery Modulates Interactions between Proteasome Core Particles and Regulatory Particles.Biomolecules2022
35858375Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.Proc Natl Acad Sci U S A2022
35664996Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.bioRxiv2022
36181684A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM.STAR Protoc2022
35940205Autoantibody mimicry of hormone action at the thyrotropin receptor.Nature2022
35902590Fusion protein strategies for cryo-EM study of G protein-coupled receptors.Nat Commun2022
36202211Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.J Biol Chem2022
35926713Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.J Biol Chem2022
35287474Sensory TRP Channels in Three Dimensions.Annu Rev Biochem2022
35169791Identification of a conserved drug binding pocket in TMEM16 proteins.Res Sq2022
34718671Classifying liganded states in heterogeneous single-particle cryo-EM datasets.Microscopy (Oxf)2022
33077960Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins.Nat Biotechnol2021
33771888A tumor-specific mechanism of T<sub>reg</sub> enrichment mediated by the integrin αvβ8.Sci Immunol2021
35059202TRPV1 and Piezo: the 2021 Nobel Prize in Physiology or Medicine.IUCrJ2021
34707294Dispatched uses Na<sup>+</sup> flux to power release of lipid-modified Hedgehog.Nature2021
34496225Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.Cell2021
34243315High-power near-concentric Fabry-Perot cavity for phase contrast electron microscopy.Rev Sci Instrum2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
33983947Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.PLoS One2021
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
33974910Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.Cell2021
32232875High-resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels.Protein Sci2020
31866389Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy.J Struct Biol2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33139559Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.Proc Natl Acad Sci U S A2020
33209325Enhancing the signal-to-noise ratio and generating contrast for cryo-EM images with convolutional neural networks.IUCrJ2020
32917864Allosteric coupling between α-rings of the 20S proteasome.Nat Commun2020
32913054General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM.Proc Natl Acad Sci U S A2020
32883800Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry.Mol Cell Proteomics2020
32737162Protein nanoribbons template enamel mineralization.Proc Natl Acad Sci U S A2020
32699850Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.bioRxiv2020
32924468Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.J Am Chem Soc2020
32814342Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.Nature2020
32641835Irritant-evoked activation and calcium modulation of the TRPA1 receptor.Nature2020
32439795Ion transport and regulation in a synaptic vesicle glutamate transporter.Science2020
30415948A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase.Mol Cell2019
31729382Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.Nat Commun2019
31867130Single-particle cryo-EM: beyond the resolution.Natl Sci Rev2019
31694242Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.Antibodies (Basel)2019
31582853Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly.Nat Struct Mol Biol2019
31210637Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.Elife2019
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Collaborators

David A Agard
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 16
Zanlin Yu
University of California at San Francisco
Co-authored papers 16
Shenping Wu
Yale University
Co-authored papers 15
Jean-Paul Armache
Center for Eukaryotic Gene Regulation, Pennsylvania State University, University Park
Co-authored papers 13
Melody G Campbell
Fred Hutchinson Cancer Center
Co-authored papers 11
Daniel Asarnow
University of California San Francisco
Co-authored papers 11
Aashish Manglik
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 10
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 9
Jianhua Zhao
University of California san francisco
Co-authored papers 8
Junrui Li
Howard Hughes Medical Institute, University of California san francisco
Co-authored papers 8
David Bulkley
University of California, San Francisco (UCSF) School of Medicine
Co-authored papers 8
Maofu Liao
Harvard Medical School
Co-authored papers 8
Kaihua Zhang
Henan Normal University
Co-authored papers 8
Feng Wang
University of California san francisco
Co-authored papers 8
Geeta J Narlikar
University of California san francisco
Co-authored papers 7
Robert M Stroud
University of California San Francisco
Co-authored papers 7
Nikolaus Grigorieff
RNA Therapeutics Institute, University of Massachusetts Chan Medical School
Co-authored papers 7
Lily Yeh Jan
Co-authored papers 6
Un Seng Chio
University of California san francisco
Co-authored papers 6
Eugene Palovcak
University of California San Francisco
Co-authored papers 6
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 5
James S Fraser
University of California san francisco
Co-authored papers 5
Axel F Brilot
University of California san francisco
Co-authored papers 5
Adam Frost
University of California San Francisco
Co-authored papers 5
Caleigh M Azumaya
Fred Hutchinson Cancer Center
Co-authored papers 5
Cristina Puchades
University of California San Francisco (UCSF) School of Medicine
Co-authored papers 5
Christian B Billesb??lle
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Ho Min Kim
Center for Biomolecular and Cellular Structure, Institute for Basic Science (IBS)
Co-authored papers 5
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 4
Lily Y-L Lee
Department of Pharmaceutical Chemistry, University of California san francisco
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Release 1.2