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Author Details

Ghazaleh Sadri-Vakili
Sean M. Healey & AMG Center for ALS at Mass General
2003
53
28
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37333415Age-dependent increase in tau phosphorylation at serine 396 in Huntington's disease pre-frontal cortex.medRxiv2023
37694372Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.J Huntingtons Dis2023
34779076Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid.Brain Pathol2022
36458209Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains.Brain Commun2022
34757590Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.Mol Neurobiol2022
32369618Lipocalin-2 is increased in amyotrophic lateral sclerosis.Muscle Nerve2020
33315879SVA insertion in X-linked Dystonia Parkinsonism alters histone H3 acetylation associated with TAF1 gene.PLoS One2020
32739252Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex.Neurobiol Dis2020
32783030Isolation of Microglia from Mouse or Human Tissue.STAR Protoc2020
30663902Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial.Amyotroph Lateral Scler Frontotemporal Degener2019
31776380Cromolyn sodium delays disease onset and is neuroprotective in the SOD1<sup>G93A</sup> Mouse Model of amyotrophic lateral sclerosis.Sci Rep2019
31241177Class I and II histone deacetylase expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and positron emission tomography molecular neuroimaging evidence.Muscle Nerve2019
31322272MDM4 expression in fibrolamellar hepatocellular carcinoma.Oncol Rep2019
29928993Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1<sup>G93A</sup> mutant mice.Mol Cell Neurosci2018
30054496Hippo Signaling Pathway Dysregulation in Human Huntington's Disease Brain and Neuronal Stem Cells.Sci Rep2018
27510168The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.Sci Rep2016
28132054Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain.Dev Neurosci2016
27605415YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma.Sci Rep2016
27716798MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.PLoS One2016
27951531Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model.Dev Neurosci2016
25349168ADAR2-dependent GluA2 editing regulates cocaine seeking.Mol Psychiatry2015
26397899Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid.J Huntingtons Dis2015
25813218Epigenetic Mechanisms Involved in Huntington's Disease Pathogenesis.J Huntingtons Dis2015
25301690Cocaine triggers epigenetic alterations in the corticostriatal circuit.Brain Res2015
23920159Mechanisms of transgenerational inheritance of addictive-like behaviors.Neuroscience2014
25392485Novel RNA modifications in the nervous system: form and function.J Neurosci2014
25072653Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration.PLoS One2014
24875096Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration.Am J Physiol Gastrointest Liver Physiol2014
24105466MeCP2: a novel Huntingtin interactor.Hum Mol Genet2014
23359110Epigenetics and psychostimulant addiction.Cold Spring Harb Perspect Med2013
25062675Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease.J Huntingtons Dis2013
24367698Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment.PLoS One2013
23872847Targeting H3K4 trimethylation in Huntington disease.Proc Natl Acad Sci U S A2013
23242310Epigenetic inheritance of a cocaine-resistance phenotype.Nat Neurosci2013
22043863Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters.J Neurochem2012
22848491Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.PLoS One2012
22508027Multiple phenotypes in Huntington disease mouse neural stem cells.Mol Cell Neurosci2012
22590724Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.Neurobiol Dis2012
21940433Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain.J Neurosci2011
20613636Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.J Neuropathol Exp Neurol2010
20810894Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.J Neurosci2010
18400894Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.J Neurosci2008
18923047Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.J Neurosci2008
18772319Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.J Pharmacol Exp Ther2008
18945913Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking.J Neurosci2008
1860809150bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis.Amyotroph Lateral Scler2008
18278040CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.Nat Neurosci2008
17409194Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.Hum Mol Genet2007
16442295Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.Neurobiol Dis2006
17017871Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).Curr Alzheimer Res2006
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Collaborators

Jang-Ho J Cha
Novartis Institutes for Biomedical Research
Co-authored papers 17
Gavin R Sangrey
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 9
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Co-authored papers 8
Eva Xia
Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 5
Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
Co-authored papers 5
James D Berry
Sean M Healey & AMG Center for ALS, Massachusetts General Hospital
Co-authored papers 5
Caroline L Benn
Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd.
Co-authored papers 4
Tim Clark
Co-authored papers 4
George J Yohrling
CHDI Management/CHDI Foundation
Co-authored papers 4
Timothy Clark (CM4AI)
University of Virginia
Co-authored papers 4
Ruth Luthi-Carter
University of Leicester
Co-authored papers 3
Prianka Chawla
Center for Regenerative Therapies Dresden, Technische Universitat Dresden
Co-authored papers 3
Alexandre Kuhn
Institute of Biotechnology, University of Lausanne
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Co-authored papers 3
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Massachusetts General Hospital
Co-authored papers 3
Mee-Ohk Kim
University of California san francisco
Co-authored papers 3
Tingting Sun
Department of Food Engineering, Harbin University
Co-authored papers 3
B??reng??re Bouzou
Co-authored papers 2
Dmitriy Leyfer
Boston University
Co-authored papers 2
Sudeshna Das
Massachusetts General Hospital
Co-authored papers 2
Steven E Arnold
Massachusetts General Hospital
Co-authored papers 2
Derek P DiRocco
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 2
Leslie M Thompson
Co-authored papers 2
Scott A Shaffer
Co-authored papers 1
David E Housman
Co-authored papers 1
Karin M Green
Co-authored papers 1
Darlene R Goldstein
Co-authored papers 1
Shaun Purcell
Brigham and Women's Hospital
Co-authored papers 1
Richard Bedlack
Duke University
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Release 1.2