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Author Details

Caroline L Benn
Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd.
2004
30
21
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
35333654Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.Proc Natl Acad Sci U S A2022
32925081Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.J Huntingtons Dis2021
32954323Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model.Brain Commun2020
33117143Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease.Front Aging Neurosci2020
31160811Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.Nat Genet2019
31297438Tackling gaps in developing life-changing treatments for dementia.Alzheimers Dement (N Y)2019
29229984Molecular and functional variation in iPSC-derived sensory neurons.Nat Genet2018
29904633Physiology of Hyperuricemia and Urate-Lowering Treatments.Front Med (Lausanne)2018
28928414Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.Sci Rep2017
28289374Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter.Front Mol Neurosci2017
27112176Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.Stem Cells Transl Med2016
26068709A novel disorder reveals clathrin heavy chain-22 is essential for human pain and touch development.Brain2015
26121260A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.PLoS One2015
24832007Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.Mol Ther2014
25136132(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.Proc Natl Acad Sci U S A2014
22140466SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.PLoS One2011
20613636Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.J Neuropathol Exp Neurol2010
18818671Mechanisms of distribution of mouse beta-galactosidase in the adult GM1-gangliosidosis brain.Gene Ther2009
19602042The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease.J Cell Mol Med2009
19484127Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.PLoS One2009
18625748A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.J Exp Med2008
18923047Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner.J Neurosci2008
18954449Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease.Mol Neurodegener2008
17409194Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.Hum Mol Genet2007
17544587Glutamate receptor abnormalities in the YAC128 transgenic mouse model of Huntington's disease.Neuroscience2007
16595660Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.J Biol Chem2006
17192438Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.J Neurosci2006
16442295Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.Neurobiol Dis2006
16183657Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.Hum Mol Genet2005
15201460Neurotransmitter receptor analysis in transgenic mouse models.Methods Mol Biol2004
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Collaborators

Jang-Ho J Cha
Novartis Institutes for Biomedical Research
Co-authored papers 10
Ghazaleh Sadri-Vakili
Sean M. Healey & AMG Center for ALS at Mass General
Co-authored papers 4
Derek P DiRocco
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 3
George J Yohrling
CHDI Management/CHDI Foundation
Co-authored papers 3
James M Olson
Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 2
Tim Clark
Co-authored papers 2
Prianka Chawla
Center for Regenerative Therapies Dresden, Technische Universitat Dresden
Co-authored papers 2
Helena Kilpinen
Co-authored papers 2
Timothy Clark (CM4AI)
University of Virginia
Co-authored papers 2
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Co-authored papers 2
Zhihua Qiu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Co-authored papers 2
Michael R Hayden
Co-authored papers 2
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Inc. University Avenue
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Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital
Co-authored papers 1
Ruth Luthi-Carter
University of Leicester
Co-authored papers 1
Jiang-Fan Chen
Co-authored papers 1
Darlene R Goldstein
Co-authored papers 1
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
Mee-Ohk Kim
University of California san francisco
Co-authored papers 1
Tingting Sun
Department of Food Engineering, Harbin University
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Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
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Richard Marcellus
Ontario Institute for Cancer Research, University Avenue
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Simon Lovestone
Janssen Medical Ltd
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University of Toronto, College St
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