Author details

Full Name

Konrad Hochedlinger

Affiliation

ORCID

Career Start Year

1999

Papers

150

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36669113	Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.	Proc Natl Acad Sci U S A	2023
36717627	Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.	Nat Cell Biol	2023
37460697	H3K36 methylation maintains cell identity by regulating opposing lineage programmes.	Nat Cell Biol	2023
37258744	Correction: Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis.		2023
34969824	Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.	Genes Dev	2022
35487911	Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.	Nature Communications	2022
36138187	NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia.	Nat Immunol	2022
34413137	Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells.	Genes Dev	2021
34711655	Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.	Genes Dev	2021
34758323	Chromatin-state barriers enforce an irreversible mammalian cell fate decision.	Cell Reports	2021
33268865	Reprogramming to recover youthful epigenetic information and restore vision.	Nature	2020
30712874	Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.	Cell	2019
31797926	Renewed proliferation in adult mouse cochlea and regeneration of hair cells.	Nature Communications	2019
31792064	Reprogramming: identifying the mechanisms that safeguard cell identity.	Development (Cambridge)	2019
31588046	The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.	Cell Stem Cell	2019
31659274	Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.	Nat Cell Biol	2019
30849376	Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.	Cell	2019
31056481	De Novo DNA Methylation at Imprinted Loci during Reprogramming intoÂ Naive and Primed Pluripotency.	Stem Cell Reports	2019
29804889	An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition.		2018
30220521	Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.	Cell Stem Cell	2018
30017590	Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming.		2018
30526885	Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate.	Cell Stem Cell	2018
30127506	Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.	Nat Methods	2018
30463679	Novel Roles for SUMOylation in Cellular Plasticity.	Trends in Cell Biology	2018
29373832	Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.	Cell	2018
29249356	Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.	Cell	2018
29742392	Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.	Stem Cell Reports	2018
28746311	Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells.	Nature	2017
28692904	Emerging roles of the histone chaperone CAF-1 in cellular plasticity.	Current Opinion in Genetics and Development	2017
28684528	Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/Î²-Catenin Activation.	Cancer Research	2017
28485378	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.	Nature Communications	2017
28366588	DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.	Cell Stem Cell	2017
27498859	Sox2 Suppresses Gastric Tumorigenesis in Mice.	Cell Rep	2016
27152443	Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming.	Cell Stem Cell	2016
27281201	Cell reprogramming: Brain versus brawn.	Nature	2016
26947976	A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.	Stem Cell Reports	2016
27476976	Î±-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells.	Cell Metab	2016
27486249	Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells.	Proceedings of the National Academy of Sciences of the United States of America	2016
26675727	Corrigendum: Hallmarks of pluripotency.	Nature	2016
26675720	Corrigendum: Failure to replicate the STAP cell phenomenon.	Nature	2016
28009305	Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells.	Cell Rep	2016
26445504	Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency.	PLoS ONE	2015
25915124	The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.	Nat Cell Biol	2015
26659182	The histone chaperone CAF-1 safeguards somatic cell identity.	Nature	2015
26098450	Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage.	Nature Biotechnology	2015
26399835	Failure to replicate the STAP cell phenomenon.	Nature	2015
26399828	Hallmarks of pluripotency.	Nature	2015
26299972	PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.	Cell Rep	2015
26501951	A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.	Nat Biotechnol	2015
26626939	Induced Pluripotency and Epigenetic Reprogramming.	Cold Spring Harbor perspectives in biology	2015