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Author Details

Daniel L Minor
Cardiovascular Research Institute, University of California san francisco
1994
87
40
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37196677EMC chaperone-Ca<sub>V</sub> structure reveals an ion channel assembly intermediate.Nature2023
37905049Development of covalent chemogenetic K<sub>2P</sub> channel activators.bioRxiv2023
36973510Structural basis for Ca<sub>V</sub>α<sub>2</sub>δ:gabapentin binding.Nat Struct Mol Biol2023
36279441Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.Proc Natl Acad Sci U S A2022
35655098Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.Nat Struct Mol Biol2022
36494348Selective posttranslational inhibition of Ca<sub>V</sub>β<sub>1</sub>-associated voltage-dependent calcium channels with a functionalized nanobody.Nat Commun2022
34059292Preface.Methods Enzymol2021
33887333Structural Insights into the Mechanisms and Pharmacology of K<sub>2P</sub> Potassium Channels.J Mol Biol2021
35138610The Polysite Pharmacology of TREK K<sub>2P</sub> Channels.Adv Exp Med Biol2021
34351379Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.J Gen Physiol2021
34099184Preface.Methods Enzymol2021
34099170Production of K<sub>2P</sub>2.1 (TREK-1) for structural studies.Methods Enzymol2021
34120727Preface.Methods Enzymol2021
34119492Inroads into Membrane Physiology through Transport Nanomachines.J Mol Biol2021
34119491Ion Channels: Intersection of Structure, Function, and Pharmacology.J Mol Biol2021
33127683K<sub>2P</sub> channel C-type gating involves asymmetric selectivity filter order-disorder transitions.Sci Adv2020
32059793Polynuclear Ruthenium Amines Inhibit K<sub>2P</sub> Channels via a "Finger in the Dam" Mechanism.Cell Chem Biol2020
31082439SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation.J Mol Biol2019
31223657Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.Sci Adv2019
30733149A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.Neuron2019
29340775Global versus local mechanisms of temperature sensing in ion channels.Pflugers Arch2018
30089357Protein and Chemical Determinants of BL-1249 Action and Selectivity for K<sub>2P</sub> Channels.ACS Chem Neurosci2018
29429937A Calmodulin C-Lobe Ca<sup>2+</sup>-Dependent Switch Governs Kv7 Channel Function.Neuron2018
29336885Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.Structure2018
28693035K<sub>2P</sub>2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.Nature2017
28278376Stapled Voltage-Gated Calcium Channel (Ca<sub>V</sub>) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of Ca<sub>V</sub> Function.ACS Chem Neurosci2017
29051229Channel surfing uncovers a dual-use transporter.EMBO J2017
29236684Cryo-EM structures of the TMEM16A calcium-activated chloride channel.Nature2017
26919429Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.Cell2016
26871624Let It Go and Open Up, an Ensemble of Ion Channel Active States.Cell2016
25158094Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.J Mol Biol2015
25542854Insights into the molecular foundations of electrical excitation.J Mol Biol2015
24120938Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.J Mol Biol2014
25500157Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.Neuron2014
25028803Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.ACS Chem Neurosci2014
23178170Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.J Mol Biol2013
24183018Conduits of life's spark: a perspective on ion channel research since the birth of neuron.Neuron2013
23738709A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.ACS Chem Biol2013
23811053Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.J Mol Biol2013
23576756Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).Proc Natl Acad Sci U S A2013
23494370Using yeast to study potassium channel function and interactions with small molecules.Methods Mol Biol2013
23561519Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi.Biophys J2013
22562138A glutamate switch controls voltage-sensitive phosphatase function.Nat Struct Mol Biol2012
22728824Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.EMBO J2012
21712653Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.Channels (Austin)2011
22179068Chemical informatics and target identification in a zebrafish phenotypic screen.Nat Chem Biol2011
21765396Multiple modalities converge on a common gate to control K2P channel function.EMBO J2011
21746903Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.Proc Natl Acad Sci U S A2011
20364128Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.Nat Chem Biol2010
21139419Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Channels (Austin)2010
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Collaborators

Lily Yeh Jan
Co-authored papers 6
Ehud Y Isacoff
University of California berkeley
Co-authored papers 6
James M Holton
Lawrence Berkeley National Laboratory
Co-authored papers 3
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Eun Young Kim
College of Korean Medicine, Kyung Hee University
Co-authored papers 3
Greg L Hura
Lawrence Berkeley National Laboratory, University of California Santa Cruz
Co-authored papers 2
William F DeGrado
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
William Harries
University of California san francisco
Co-authored papers 1
Shaun R Coughlin
Co-authored papers 1
H R Kaback
University of California los angeles
Co-authored papers 1
Henning Stahlberg
Ecole Polytechnique Federale de Lausanne (EPFL), University of Lausanne
Co-authored papers 1
Jianhua Zhao
University of California san francisco
Co-authored papers 1
Vincent Setola
West Virginia University School of Medicine
Co-authored papers 1
Michael J Keiser
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 1
Brian K Shoichet
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
John J Irwin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Hyunil Jo
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 1
Bryan L Roth
UNC Chapel Hill School of Medicine
Co-authored papers 1
Yifan Cheng
Quantitative Bioscience Institute, University of California san francisco
Co-authored papers 1
Robert M Stroud
University of California San Francisco
Co-authored papers 1
Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Witek Kwiatkowski
Swiss Federal Institute of Technology
Co-authored papers 1
David Bulkley
University of California, San Francisco (UCSF) School of Medicine
Co-authored papers 1
Roland Riek
ETH Zurich
Co-authored papers 1
Henry Lin
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 1
Michael Burgess
Co-authored papers 1
Senyon Choe
Joint Center for Biosciences
Co-authored papers 1
Release 1.2