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Author Details

Senthil K Muthuswamy
Center for Cancer Research, National Cancer Institute, National Institutes of Health
1992
92
47
PMIDPaper TitleJournal TitlePublished Year
36755019Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT.Nat Commun2023
38016469TScan-II: A genome-scale platform for the de novo identification of CD4<sup>+</sup> T cell epitopes.Cell2023
37886440Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer.Res Sq2023
35834008Personalized tumor vaccine for pancreatic cancer.Cancer Immunol Immunother2023
36993200A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer.medRxiv2023
36789419Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids.bioRxiv2023
34789479Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer.Clin Cancer Res2022
35501367Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer.Commun Biol2022
35446942Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer.Cancer Immunol Res2022
35058633Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8.Nat Metab2022
34388391Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.Cell2021
33513348Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis.Cancer Cell2021
33707480Elevated levels of mitochondrial CoQ<sub>10</sub> induce ROS-mediated apoptosis in pancreatic cancer.Sci Rep2021
33915081Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.Cell Stem Cell2021
34452919Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.Sci Adv2021
32499301Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells.Mol Cancer Ther2020
32990680PDX-derived organoids model in vivo drug response and secrete biomarkers.JCI Insight2020
32790356Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6<i>H</i>-benzo[<i>e</i>]pyrimido[5,4-<i>b</i>][1,4]diazepin-6-one Scaffold".J Med Chem2020
32530623Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6<i>H</i>-benzo[<i>e</i>]pyrimido[5,4-<i>b</i>][1,4]diazepin-6-one Scaffold.J Med Chem2020
30996345LLGL2 rescues nutrient stress by promoting leucine uptake in ER<sup>+</sup> breast cancer.Nature2019
31775037Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis.Cell Rep2019
29330203Personalized RNA Medicine for Pancreatic Cancer.Clin Cancer Res2018
29924804Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.PLoS Biol2018
30366626Golgi Stabilization, Not Its Front-Rear Bias, Is Associated with EMT-Enhanced Fibrillar Migration.Biophys J2018
29499146Organoid Models of Cancer Explode with Possibilities.Cell Stem Cell2018
29369778Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion.Biochim Biophys Acta Rev Cancer2018
28805820Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.Nat Med2017
28292842Bringing together the organoid field: from early beginnings to the road ahead.Development2017
29463399Editorial overview: Cell differentiation and development: New kids in the block-new tools and concepts opening new doors in development.Curr Opin Cell Biol2017
27179074Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.J Cell Sci2016
27705778Positive Quantitative Relationship between EMT and Contact-Initiated Sliding on Fiber-like Tracks.Biophys J2016
27694890An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.Nat Cell Biol2016
27119647Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement.Biophys J2016
25681440A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.J Biol Chem2015
26501191Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.Nat Med2015
24662921Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.Cancer Res2014
24845231Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.Nat Chem Biol2014
24599592G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.Proc Natl Acad Sci U S A2014
23248267Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly.Proc Natl Acad Sci U S A2013
23263278Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.Nat Cell Biol2013
22245967The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation.Nat Struct Mol Biol2012
23070811Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports.Genes Dev2012
22851698Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.Mol Cell Biol2012
22883624The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.Mol Cell2012
22881459Cell polarity as a regulator of cancer cell behavior plasticity.Annu Rev Cell Dev Biol2012
22529912Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells.PLoS One2012
21475230Trastuzumab resistance: all roads lead to SRC.Nat Med2011
21610111Epithelial cell organization suppresses Myc function by attenuating Myc expression.Cancer Res2011
21724833Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.Genes Dev2011
213492093D culture reveals a signaling network.Breast Cancer Res2011
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Collaborators

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Bharathidasan University, Indian Institute of Science
Co-authored papers 2
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Boston University School of Medicine, Boston University
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Princess Margaret Cancer Centre, University Health Network, University of Toronto
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University of Texas Southwestern Medical Center
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The Weizmann Institute of Science
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