Skip to Main Content

Author Details

Michael G Malkowski
Jacobs School of Medicine and Biomedical Sciences, University of Buffalo
1992
58
27
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36715541Anti-Ï¿<sup>28</sup> Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola.J Bacteriol2023
37852627Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase-2.Biochemistry2023
37747935Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.PLoS Pathog2023
31854058An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells.Angew Chem Int Ed Engl2020
30883947Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi.Mol Microbiol2019
30096040Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.FASEB J2019
31469551Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.Biochemistry2019
30710016Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2.J Biol Chem2019
29203544Mapping Protective Regions on a Three-Dimensional Model of the Moraxella catarrhalis Vaccine Antigen Oligopeptide Permease A.Infect Immun2018
28659326A Cation-Binding Surface Protein as a Vaccine Antigen To Prevent Moraxella catarrhalis Otitis Media and Infections in Chronic Obstructive Pulmonary Disease.Clin Vaccine Immunol2017
26859324Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.Biochemistry2016
27756840Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.J Biol Chem2016
27710942Crystal structure of rofecoxib bound to human cyclooxygenase-2.Acta Crystallogr F Struct Biol Commun2016
27265455Sulfate-binding protein, CysP, is a candidate vaccine antigen of Moraxella catarrhalis.Vaccine2016
27226593Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.J Biol Chem2016
25463020The structure of ibuprofen bound to cyclooxygenase-2.J Struct Biol2015
26515067The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase.J Biol Chem2015
26597985The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis.Infect Immun2015
26321039Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding.J Struct Biol2015
26636181Pulsed Dipolar Spectroscopy Reveals That Tyrosyl Radicals Are Generated in Both Monomers of the Cyclooxygenase-2 Dimer.Biochemistry2015
25805501Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN.J Biol Chem2015
24503478Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs.Arch Biochem Biophys2014
25156736Role of the oligopeptide permease ABC Transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract.Infect Immun2014
23373518The crystal structure of α-Dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily.Biochemistry2013
23817618Role of the zinc uptake ABC transporter of Moraxella catarrhalis in persistence in the respiratory tract.Infect Immun2013
23934749Crystal structures of α-dioxygenase from Oryza sativa: insights into substrate binding and activation by hydrogen peroxide.Protein Sci2013
23381628Coordinating the impact of structural genomics on the human α-helical transmembrane proteome.Nat Struct Mol Biol2013
23539602Structure of the integral membrane protein CAAX protease Ste24p.Science2013
22637474Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove.J Biol Chem2012
21489986The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.J Biol Chem2011
21843643The structure of NS-398 bound to cyclooxygenase-2.J Struct Biol2011
21965687The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.J Biol Chem2011
21467029Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.J Biol Chem2011
20045057Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography.Protein Expr Purif2010
20450491Pleiotropic mechanisms facilitated by resveratrol and its metabolites.Biochem J2010
20463020Structural basis of fatty acid substrate binding to cyclooxygenase-2.J Biol Chem2010
19554626Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins.Protein Sci2009
18235432Structural genomics: from genes to structures with valuable materials and many questions in between.Nat Methods2008
19020351Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples.Acta Crystallogr D Biol Crystallogr2008
19020350Establishing a training set through the visual analysis of crystallization trials. Part I: approximately 150,000 images.Acta Crystallogr D Biol Crystallogr2008
18596034His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase.J Biol Chem2008
17426150Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.Proc Natl Acad Sci U S A2007
17327388Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature.Protein Sci2007
16582486Purification, crystallization and preliminary X-ray diffraction analysis of pathogen-inducible oxygenase (PIOX) from Oryza sativa.Acta Crystallogr Sect F Struct Biol Cryst Commun2006
12432914The structures of prostaglandin endoperoxide H synthases-1 and -2.Prostaglandins Other Lipid Mediat2002
11121413Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases.J Biol Chem2001
11477109Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.J Biol Chem2001
11121412Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.J Biol Chem2001
10988074The productive conformation of arachidonic acid bound to prostaglandin synthase.Science2000
10900130The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1.Arch Biochem Biophys2000
  • 1 - 50 of 58

Recommended Authors

ShanghaiTech University, China iHuman Institute
Career Start Year 2006
Number of shared co-authors 2
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 2002
Number of shared co-authors 1
Bragg Institute
Career Start Year 2000
Number of shared co-authors 2
University of California san francisco
Career Start Year 2000
Number of shared co-authors 3
Incyte Corporation
Career Start Year 2000
Number of shared co-authors 1
University of South Carolina, Michigan State University
Career Start Year 2000
Number of shared co-authors 1
Albert Einstein College of Medicine
Career Start Year 1999
Number of shared co-authors 4
New York University Grossman School of Medicine
Career Start Year 1998
Number of shared co-authors 1
Weizmann Institute of Science
Career Start Year 1995
Number of shared co-authors 2
Beth Israel Deaconess Medical Center and Harvard Medical School
Career Start Year 1994
Number of shared co-authors 2
Kangwon National University College of Medicine
Career Start Year 1993
Number of shared co-authors 2
Argonne National Laboratory
Career Start Year 1993
Number of shared co-authors 2
University of Texas Southwestern Medical Center
Career Start Year 1993
Number of shared co-authors 1
University of North Carolina at Chapel Hill
Career Start Year 1993
Number of shared co-authors 0
Argonne National Laboratory
Career Start Year 1992
Number of shared co-authors 0
Bridge Institute, University of Southern California
Career Start Year 1991
Number of shared co-authors 3
The State University of New Jersey
Career Start Year 1991
Number of shared co-authors 2
University of Milano
Career Start Year 1991
Number of shared co-authors 0
University of California irvine
Career Start Year 1991
Number of shared co-authors 0
University of Virginia
Career Start Year 1989
Number of shared co-authors 2
Karolinska Institutet, BioClinicum J6
Career Start Year 1989
Number of shared co-authors 2
Lilly Research Laboratories
Career Start Year 1988
Number of shared co-authors 1
Albert Einstein College of Medicine
Career Start Year 1988
Number of shared co-authors 4
Boston University
Career Start Year 1987
Number of shared co-authors 0
Case Western Reserve University
Career Start Year 1986
Number of shared co-authors 5
Abo Akademi University
Career Start Year 1985
Number of shared co-authors 1
Bristol-Myers Squibb Pharmaceutical Research Institute
Career Start Year 1985
Number of shared co-authors 1
The State University of New Jersey
Career Start Year 1975
Number of shared co-authors 1
University of Milano
Career Start Year 1975
Number of shared co-authors 2
Heartand Lung Research Institute, University of Cambridge
Career Start Year 1971
Number of shared co-authors 2

Collaborators

University of Rochester Medical Center
Co-authored papers 4
University of Virginia
Co-authored papers 2
University of Wisconsin-Madison
Co-authored papers 2
NYU School of Medicine
Co-authored papers 2
Schroeder Arthritis Institute
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
Co-authored papers 1
Technical University of Munich (TUM)
Co-authored papers 1
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Columbia University
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
University of Colorado Boulder
Co-authored papers 1
Howard Hughes Medical Institute, California Institute of Technology
Co-authored papers 1
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Skaggs School of Pharmacy and Pharmaceutical Sciences.
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Institute for Advanced Study (TUM-IAS), TUM (Technische Universitat Munchen)
Co-authored papers 1
University of Illinois at Urbana-Champaign
Co-authored papers 1
Biodesign Center for Applied Structural Discovery, Arizona State University
Co-authored papers 1
University of California san francisco
Co-authored papers 1