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Author Details

Alexei Savchenko
University of Toronto
1997
204
51
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37973888Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.Nat Chem Biol2024
36511702Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice.Infect Immun2023
37747257A high-throughput structural system biology approach to increase structure representation of proteins from <i>Clostridioides difficile</i>.Microbiol Resour Announc2023
37689947A simple and robust serum-free media for the proliferation of muscle cells.Food Res Int2023
37819088Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of <i>Legionella pneumophila</i>.mBio2023
37256116Graphene-based cardiac sensors and actuators.Front Bioeng Biotechnol2023
37419898Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.Nat Commun2023
36946756Correction for Popov et al., "Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for Different Roles during Citrobacter rodentium Infection in Mice".Infect Immun2023
37314918Protein expression and purification of bioactive growth factors for use in cell culture and cellular agriculture.STAR Protoc2023
37437000Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases.FEBS J2023
37264151Structural analysis of a hormone-bound Striga strigolactone receptor.Nat Plants2023
36880269Monomer and dimer structures of cytochrome bo<sub>3</sub> ubiquinol oxidase from Escherichia coli.Protein Sci2023
36719236Thermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins.Appl Environ Microbiol2023
36809010Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.mBio2023
34643018Defluorination Capability of l-2-Haloacid Dehalogenases in the HAD-Like Hydrolase Superfamily Correlates with Active Site Compactness.Chembiochem2022
35531664High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11.mSphere2022
35512834Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in <i>Candida albicans</i>.Life Sci Alliance2022
35872379Advances in engineering and optimization of transcription factor-based biosensors for plug-and-play small molecule detection.Curr Opin Biotechnol2022
36229448Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections.Nat Commun2022
35181340A novel strigolactone receptor antagonist provides insights into the structural inhibition, conditioning, and germination of the crop parasite Striga.J Biol Chem2022
35338238Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.Commun Biol2022
33319167Structural characterization of nonstructural protein 1 from SARS-CoV-2.iScience2021
33563840ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin.mBio2021
34686660A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.Nat Commun2021
34592310Structural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans.J Biol Chem2021
34064722Identification of a Novel Biosynthetic Gene Cluster in <i>Aspergillus niger</i> Using Comparative Genomics.J Fungi (Basel)2021
32579338Biocatalytic <i>in Vitro</i> and <i>in Vivo</i> FMN Prenylation and (De)carboxylase Activation.ACS Chem Biol2020
31876342Structure of the full-length Serratia marcescens acetyltransferase AAC(3)-Ia in complex with coenzyme A.Protein Sci2020
31899563Molecular mechanisms of vancomycin resistance.Protein Sci2020
31806708Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of (<i>R</i>)-1,3-butanediol.J Biol Chem2020
31927042A penicillin-binding protein that can promote advanced-generation cephalosporin resistance and genome adaptation in the opportunistic pathogen Pseudomonas aeruginosa.Int J Antimicrob Agents2020
31924499Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.Cell Chem Biol2020
31891426Structural characterization of aminoglycoside 4'-O-adenylyltransferase ANT(4')-IIb from Pseudomonas aeruginosa.Protein Sci2020
31886667One-Pot Biocatalytic Transformation of Adipic Acid to 6-Aminocaproic Acid and 1,6-Hexamethylenediamine Using Carboxylic Acid Reductases and Transaminases.J Am Chem Soc2020
32094588Envelope stress responses defend against type six secretion system attacks independently of immunity proteins.Nat Microbiol2020
31196922Complete Genome Sequence of Citrobacter rodentium Strain DBS100.Microbiol Resour Announc2019
31695193An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.Nature2019
31324716Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74.J Biol Chem2019
29317655The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.Nat Commun2018
30217892Functional diversification of the NleG effector family in enterohemorrhagic <i>Escherichia coli</i>.Proc Natl Acad Sci U S A2018
30120235Galectin-9 binds IgM-BCR to regulate B cell signaling.Nat Commun2018
30463871Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74 <i>endo</i>-xyloglucanase.Biochem J2018
30284819Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters.Environ Sci Technol2018
30382091Identification and characterization of a large family of superbinding bacterial SH2 domains.Nat Commun2018
29642013Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.Cell Rep2018
29634241Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.ACS Infect Dis2018
29631403Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.ACS Chem Biol2018
29398560Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.Cell Chem Biol2018
29182315Determinants and Prediction of Esterase Substrate Promiscuity Patterns.ACS Chem Biol2018
29301934The <i>Legionella pneumophila</i> effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.J Biol Chem2018
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Collaborators

Elena Evdokimova
University of Toronto
Co-authored papers 57
Aled M Edwards
University of Toronto
Co-authored papers 51
Andrzej Joachimiak
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 41
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 28
Wladek Minor
University of Virginia
Co-authored papers 20
Maksymilian Chruszcz
University of South Carolina, Michigan State University
Co-authored papers 19
Adelinda Yee
University of Toronto
Co-authored papers 11
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Argonne National Laboratory
Co-authored papers 8
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University of Toronto
Co-authored papers 5
Olga Kagan
Molloy University, NY The City University of New York School of Professional Studies
Co-authored papers 4
Alexey Bochkarev
University of Toronto
Co-authored papers 4
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Pacific Northwest National Laboratory
Co-authored papers 4
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Co-authored papers 4
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Columbia University
Co-authored papers 3
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University of Virginia
Co-authored papers 3
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EMBL--European Bioinformatics Institute
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Nara Institute of Science and Technology
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Pacific Northwest National Laboratory
Co-authored papers 3
Mark Gerstein
Yale University
Co-authored papers 3
Rong Xiao
School of Public Health, Capital Medical University
Co-authored papers 2
Joshua D Rabinowitz
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 2
Ernesto S Nakayasu
Co-authored papers 2
Gaetano T Montelione
Rensselaer Polytechnic Institute
Co-authored papers 2
Sirano Dhe-Paganon
Dana-Farber Cancer Institute
Co-authored papers 2
Alex Ignatchenko
European Bioinformatics Institute (EMBL-EBI)
Co-authored papers 2
Eric D Cambronne
The University of Texas at Austin
Co-authored papers 2
Hee-Won Park
Kangwon National University College of Medicine
Co-authored papers 2
Luke Whitesell
University of Toronto
Co-authored papers 2
Michael A Kennedy
Miami University
Co-authored papers 2
Release 1.2