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Author Details

David Ron
Cambridge Institute for Medical Research, University of Cambridge
1979
262
115
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36041787AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis.Cold Spring Harb Perspect Biol2023
36704923Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.EMBO Mol Med2023
34702991Pharmacological targeting of endoplasmic reticulum stress in disease.Nat Rev Drug Discov2022
35171481Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay.Methods Mol Biol2022
33220178ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.Mol Cell2021
34408154Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.Nat Commun2021
34625748Higher-order phosphatase-substrate contacts terminate the integrated stress response.Nat Struct Mol Biol2021
34010647Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers.Cell Rep2021
32620695Correction: Thioredoxin-related protein 32 is an arsenite-regulated thiol reductase of the proteasome 19 S particle.J Biol Chem2020
31875646GDF15 mediates the effects of metformin on body weight and energy balance.Nature2020
32051582Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.Nature2020
31882561De Novo Mutations in <i>EIF2B1</i> Affecting eIF2 Signaling Cause Neonatal/Early-Onset Diabetes and Transient Hepatic Dysfunction.Diabetes2020
33295873Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes.Elife2020
30396883Early Events in the Endoplasmic Reticulum Unfolded Protein Response.Cold Spring Harb Perspect Biol2019
31873072Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.Elife2019
31749445The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.Elife2019
31531998An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.EMBO J2019
30710085MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.Nat Commun2019
29599245Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.Science2018
30068912Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.Sci Rep2018
30224760Single particle trajectories reveal active endoplasmic reticulum luminal flow.Nat Cell Biol2018
30510064Erratum: Early Events in the Endoplasmic Reticulum Unfolded Protein Response.Cold Spring Harb Perspect Biol2018
29649448Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.Cell Host Microbe2018
29618508A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.J Biol Chem2018
27918543FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.Nat Struct Mol Biol2017
28082357Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.J Exp Med2017
28447936PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.Elife2017
28347335TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H<sub>2</sub>O<sub>2</sub>.BMC Biol2017
29198525A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.Cell2017
29064368AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.Elife2017
28831037The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation.Sci Rep2017
28775151The requirement of IRE1 and XBP1 in resolving physiological stress during <i>Drosophila</i> development.J Cell Sci2017
28615323Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy.Mol Biol Cell2017
27181404PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.Am J Pathol2016
26487695Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.FASEB J2016
27812215Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.PLoS One2016
27802424Dual role of the integrated stress response in medulloblastoma tumorigenesis.Oncotarget2016
25543896Lipid-dependent regulation of the unfolded protein response.Curr Opin Cell Biol2015
26673894AMPylation matches BiP activity to client protein load in the endoplasmic reticulum.Elife2015
26504166ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding.J Cell Biol2015
26317833Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization.PLoS One2015
26526393ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.Neuron2015
26473973Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.Elife2015
26159176A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.Diabetes2015
25858979Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.Science2015
25762312A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth.Biophys J2015
25774600G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.Elife2015
25774599Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.Elife2015
25741597Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.Cell Death Dis2015
25575667Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.BMC Biol2015
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Collaborators

Cole M Haynes
university of massachusetts amherst Chan Medical School
Co-authored papers 10
Claudia Rato
Co-authored papers 8
Thomas A Neubert
Neuroscience Institute, NYU Grossman School of Medicine
Co-authored papers 7
King-Tung Chin
The University of Hong Kong
Co-authored papers 7
Marcella Calfon Press
David Geffen School of Medicine at university of california los angeles
Co-authored papers 5
Peter Walter
University of California san francisco
Co-authored papers 5
John C Bell
Ottawa Hospital Research Institute
Co-authored papers 4
Robert L Wiseman
The Scripps Research Institute
Co-authored papers 4
Michele Vendruscolo
University of Cambridge
Co-authored papers 4
Stephen O'Rahilly
Co-authored papers 4
Ariel Stanhill
Open University of Israel
Co-authored papers 4
Yi-Chun Loraine Tung
Co-authored papers 3
Randy J Read
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 3
Andrew T Hattersley
Co-authored papers 3
Chong-Feng Xu
Biogen Inc.
Co-authored papers 3
Randolph Y Hampton
University of California San Diego
Co-authored papers 2
Decio L Eizirik
Co-authored papers 2
Douglas R Cavener
Co-authored papers 2
Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 2
Krishna S Nair
Co-authored papers 2
Miriam Cnop
Co-authored papers 2
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Michael G Katze
University of Washington
Co-authored papers 2
Nathalie Conte
The Wellcome Trust Sanger Institute
Co-authored papers 2
Naveed Sattar
Co-authored papers 2
Nicholas J Wareham
Co-authored papers 2
Daniel Birnbaum
Co-authored papers 2
Yihong Ye
National Institute of Diabetes, National Institutes of Health
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Asa Wahlander
Co-authored papers 1
Release 1.2